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    Process for the preparation of intermediates of perindopril
    2.
    发明申请
    Process for the preparation of intermediates of perindopril 审中-公开
    培哚普利中间体的制备方法

    公开(公告)号：US20070032661A1

    公开(公告)日：2007-02-08

    申请号：US11495102

    申请日：2006-07-28

    申请人： Narendra Joshi ,  Buddhavarapu Ramam ,  Arjun Bodkhe

    发明人： Narendra Joshi ,  Buddhavarapu Ramam ,  Arjun Bodkhe

    IPC分类号： C07D209/42

    CPC分类号： C07D209/42

    摘要： A process for the preparation of (2S, 3aS, 7aS)perhydroindole-2-carboxylic acid is provided comprising (a) esterifying a cis-perhydroindole-2-carboxylic acid with a first alcohol of the formula ROH and a suitable free acid to provide the acid salt (AS) of Formula V: (b) reacting the acid salt of Formula V with a first base to provide a compound of Formula VI: (c) treating the product of step (b) with an L-tartaric containing acid in a second alcohol of the formula ROH to precipitate a compound of Formula VII: (d) reacting the compound of Formula VII with a second base to provide a compound of Formula II (e) hydrolyzing the compound of Formula II to provide the (2S, 3aS, 7aS)perhydroindole-2-carboxylic acid.

    摘要翻译： 提供了制备（2S，3aS，7aS）全氢吲哚-2-羧酸的方法，其包括（a）使顺式 - 全氢吲哚-2-羧酸与式ROH的第一醇和合适的游离酸酯化，以提供 式Ⅴ的酸性盐（AS）：（b）使式Ⅴ的酸式盐与第一碱反应以提供式Ⅵ化合物：（ⅲ）用含L-酒石酸的酸处理步骤（b）的产物 在式ROH的第二个醇中，使式VII化合物沉淀：（d）使式VII化合物与第二碱反应，得到式II化合物（e）水解式II化合物，得到（2S ，3aS，7aS）全氢吲哚-2-羧酸。

    Process for the preparation of angiotensin receptor blockers and intermediates thereof
    4.
    发明申请
    Process for the preparation of angiotensin receptor blockers and intermediates thereof 审中-公开
    制备血管紧张素受体阻滞剂及其中间体的方法

    公开(公告)号：US20060211866A1

    公开(公告)日：2006-09-21

    申请号：US11386010

    申请日：2006-03-21

    申请人： Narendra Joshi ,  Kodali Rao ,  Buddhavarapu Ramam ,  Shekhar Bhirud

    发明人： Narendra Joshi ,  Kodali Rao ,  Buddhavarapu Ramam ,  Shekhar Bhirud

    IPC分类号： C07D403/02 ,  C07D235/04

    CPC分类号： C07D257/04 ,  C07D235/20 ,  C07D403/10

    摘要： A process for the preparation of a biphenyl-containing compound of general formula I: wherein R1 is a C3-6 carbonyl containing compound; R2 is a substituted or unsubstituted, straight or branched C3-6 alkyl group, or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a substituted heterocyclic group selected from the group consisting of substituted or unsubstituted imidazoles, substituted or unsubstituted benzimidazoles and substituted or unsubstituted 1,3-diazaspiro[4,4]non-1-en-4-one; and R3 is a carboxylic acid ester, cyano, a substituted or unsubstituted 1H-tetrazolyl group or a substituted or unsubstituted group which may be converted in vivo into a carboxy group is provided, the process comprising reacting a compound of general formula II: wherein R1 and R2 have the aforestated meanings with a compound of general formula III: wherein Z is a leaving group and R3 has the aforestated meaning in a biphasic solvent system in the presence of a phase transfer catalyst.

    摘要翻译： 一种制备含联苯的通式I化合物的方法：其中R 1是含3-6个碳原子的化合物; R 2是取代或未取代的直链或支链C 3-6 - 烷基，或R 1和R 2， SUP与它们所键合的氮原子一起连接在一起形成选自取代或未取代的咪唑，取代或未取代的苯并咪唑和取代或未取代的1,3-二氮杂螺[4,4] 非1-烯-4-酮; R 3是可以在体内转化为羧基的羧酸酯，氰基，取代或未取代的1H-四唑基或取代或未取代的基团，该方法包括使 通式II的化合物：其中R 1和R 2具有通式III的化合物的前述含义：其中Z是离去基团，R 3 在相转移催化剂存在下，在双相溶剂体系中具有上述含义。

    Catalyst system and method
    6.
    发明申请
    Catalyst system and method 审中-公开
    催化剂体系及方法

    公开(公告)号：US20070189948A1

    公开(公告)日：2007-08-16

    申请号：US11353310

    申请日：2006-02-14

    申请人： Teresa Rocha ,  John Blouch ,  Don Hancu ,  Narendra Joshi ,  Jonathan Male ,  Alison Palmatier ,  Benjami Wood

    发明人： Teresa Rocha ,  John Blouch ,  Don Hancu ,  Narendra Joshi ,  Jonathan Male ,  Alison Palmatier ,  Benjami Wood

    IPC分类号： B01D53/46 ,  B01D47/00

    CPC分类号： B01D53/8631 ,  B01J35/0006 ,  B01J35/04

    摘要： In accordance with one embodiment of the present invention, a catalyst system is provided. The catalyst system includes a catalyst bed that comprises a plurality of catalyst segments arranged such that an exhaust flow passes along a longitudinal axis of the catalyst system through the plurality of catalyst segments from a first one of the plurality of catalyst segments through a last one of the plurality of catalyst segments, each of the plurality of catalyst segments comprising a plurality of catalytic cells, wherein a concentration of catalytic material decreases from the first one of the plurality of catalyst segments through the last one of the plurality of catalyst segments.

    摘要翻译： 根据本发明的一个实施方案，提供催化剂体系。 催化剂体系包括催化剂床，催化剂床包括多个催化剂区段，这些催化剂区段布置成使得废气流沿催化剂体系的纵轴通过多个催化剂段从多个催化剂区段中的第一个通过最后一个 多个催化剂段，多个催化剂段中的每一个包括多个催化单元，其中催化材料的浓度从多个催化剂段中的第一个通过多个催化剂段中的最后一个催化剂段减少。

    Novel polymorph form M of mifepristone and process for its preparation
    7.
    发明申请
    Novel polymorph form M of mifepristone and process for its preparation 审中-公开
    米非司酮的新型多晶型M及其制备方法

    公开(公告)号：US20070105828A1

    公开(公告)日：2007-05-10

    申请号：US11506223

    申请日：2006-08-18

    申请人： Narendra Joshi ,  Anil Khile ,  Nitin Pradhan

    发明人： Narendra Joshi ,  Anil Khile ,  Nitin Pradhan

    IPC分类号： A61K31/56 ,  C07J7/00

    CPC分类号： C07J7/00

    摘要： Mifepristone substantially in polymorph form M is provided. Also provided is a process for the preparation of polymorph form M of mifepristone comprising the steps of (a) dissolving crude mifepristone in a polar solvent at an elevated temperature to obtain a clear solution; (b) cooling the solution to a temperature and for a time period sufficient to form a precipitate of mifepristone crystals; and (c) isolating the precipitate of mifepristone crystals to obtain the polymorph form M of mifepristone.

    摘要翻译： 提供基本上呈多晶型M的米非司酮。 还提供了制备米非司酮多晶型M的方法，包括以下步骤：（a）在高温下将粗米非司酮溶解在极性溶剂中以获得澄清溶液; （b）将溶液冷却至足以形成米非司酮晶体沉淀物的温度和时间; 和（c）分离米非司酮晶体的沉淀，得到米非司酮的多晶型M。

    Mobile gas turbine engine and generator assembly
    8.
    发明申请
    Mobile gas turbine engine and generator assembly 有权
    移动燃气涡轮发动机和发电机总成

    公开(公告)号：US20060254281A1

    公开(公告)日：2006-11-16

    申请号：US11130356

    申请日：2005-05-16

    申请人： Gilbert Badeer ,  Narendra Joshi

    发明人： Gilbert Badeer ,  Narendra Joshi

    IPC分类号： F02C7/143

    CPC分类号： F02C6/203 ,  F02C7/143 ,  F02C7/16 ,  F05B2240/931 ,  F05D2220/76 ,  Y02T50/675

    摘要： A method for supplying power to a remote load includes coupling a gas turbine engine to a vessel that is not used to provide propulsion for the vessel, coupling a generator to the gas turbine engine, coupling an intercooler system downstream from a first compressor such that compressed air discharged from the first compressor is channeled therethrough, the intercooler system includes an intercooler and a first heat exchanger, channeling a first working fluid through the intercooler to facilitate reducing an operating temperature of air discharged from the intercooler to a second compressor, channeling a second working fluid flowing through the first heat exchanger to extract energy from the first working fluid to facilitate reducing an operating temperature of the first working fluid, and operating the gas turbine engine and generator to supply power to a load that is located remotely from the vessel.

    摘要翻译： 用于向远程负载供电的方法包括将燃气涡轮发动机联接到不用于为船舶提供推进力的容器，将发电机联接到燃气涡轮发动机，将中间冷却器系统从第一压缩机下游连接到压缩机 从第一压缩机排出的空气被引导通过，中间冷却器系统包括中间冷却器和第一热交换器，将第一工作流体引导通过中间冷却器，以便于将从中间冷却器排出的空气的工作温度降低到第二压缩机， 工作流体流过第一热交换器以从第一工作流体提取能量，以便于降低第一工作流体的工作温度，以及操作燃气涡轮发动机和发电机，以向远离容器的负载供电。

    Pulse Detonation Combustor Nozzles
    10.
    发明申请
    Pulse Detonation Combustor Nozzles 审中-公开
    脉冲爆震燃烧器喷嘴

    公开(公告)号：US20120192545A1

    公开(公告)日：2012-08-02

    申请号：US13015614

    申请日：2011-01-28

    申请人： Venkat Eswarlu Tangirala ,  Narendra Joshi

    发明人： Venkat Eswarlu Tangirala ,  Narendra Joshi

    IPC分类号： F02K5/02

    CPC分类号： F02C5/11

    摘要： The present application provides a pulse detonation engine. The pulse detonation engine may include a number of pulse detonation combustors. Each of the pulse detonation combustors may include a combustion tube and a nozzle assembly. The nozzle assembly of one or more of the pulse detonation combustors may include a diffuser therein.

    摘要翻译： 本申请提供了一种脉冲爆震引擎。 脉冲爆震引擎可以包括多个脉冲爆震燃烧器。 每个脉冲爆震燃烧器可以包括燃烧管和喷嘴组件。 一个或多个脉冲爆震燃烧器的喷嘴组件可以在其中包括扩散器。