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    Delta 12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast
    4.
    发明申请
    Delta 12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast 失效
    适用于改变含油酵母中多不饱和脂肪酸水平的Delta 12去饱和酶

    公开(公告)号：US20050216975A1

    公开(公告)日：2005-09-29

    申请号：US10985691

    申请日：2004-11-10

    申请人： Narendra Yadav ,  Quinn Zhu ,  Hongxiang Zhang

    发明人： Narendra Yadav ,  Quinn Zhu ,  Hongxiang Zhang

    IPC分类号： A01H1/00 ,  C12N20060101 ,  C12N1/18 ,  C12N9/02 ,  C12N9/04 ,  C12N15/74 ,  C12N15/82 ,  C12P7/64

    CPC分类号： C12P7/6472 ,  C12N9/0083 ,  C12N15/8247 ,  C12P7/6427

    摘要： The present invention relates to fungal Δ12 fatty acid desaturases that are able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific ω-3 and ω-6 fatty acids by over-expression of the Δ12 fatty acid desaturases are also described herein.

    摘要翻译： 本发明涉及能够催化油酸转化为亚油酸（LA; 18：2）的真菌Delta12脂肪酸去饱和酶。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主微生物。 本文还描述了通过过表达Delta12脂肪酸去饱和酶增加特定ω-3和ω-6脂肪酸的产生的方法。

    Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
    5.
    发明申请
    Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts 失效
    用于改变多不饱和脂肪酸的酰基转移酶和含油酵母中的油含量

    公开(公告)号：US20070054385A1

    公开(公告)日：2007-03-08

    申请号：US11592806

    申请日：2006-11-03

    申请人： Narendra Yadav ,  Hongxiang Zhang

    发明人： Narendra Yadav ,  Hongxiang Zhang

    IPC分类号： C12P7/64 ,  C07H21/04 ,  C12P21/06 ,  C12N9/10 ,  C12N15/74 ,  C12N1/18

    CPC分类号： C12P7/6481 ,  C12N9/1029 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

    摘要： Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) and diacylglycerol acyltransferase (DGAT2) have been isolated from Y. lipolytica. These genes encode enzymes that participate in the terminal step in oil biosynthesis in yeast. Each is expected to play a key role in altering the quantity of polyunsaturated fatty acids produced in oils of oleaginous yeasts.

    摘要翻译： 提供两种酰基转移酶，适用于制造含油酵母（例如解脂耶氏酵母）富含ω-脂肪酸的微生物油。 具体地说，从解脂耶氏酵母中分离出编码磷脂酰胆碱 - 二酰基甘油酰基转移酶（PDAT）和二酰基甘油酰基转移酶（DGAT2）的基因。 这些基因编码酵母中参与油生物合成的最终步骤的酶。 预计每一种在改变油质酵母油中产生的多不饱和脂肪酸的量方面起关键作用。

    DIACYLGLYCEROL ACYLTRANSFERASES FOR ALTERATION OF POLYUNSATURATED FATTY ACIDS AND OIL CONTENT IN OLEAGINOUS ORGANISMS
    6.
    发明申请
    DIACYLGLYCEROL ACYLTRANSFERASES FOR ALTERATION OF POLYUNSATURATED FATTY ACIDS AND OIL CONTENT IN OLEAGINOUS ORGANISMS 审中-公开
    用于改变脂肪酸和脂肪酸含量的二油酸甘油酯

    公开(公告)号：US20080020415A1

    公开(公告)日：2008-01-24

    申请号：US11830023

    申请日：2007-07-30

    申请人： Narendra Yadav ,  Zhixiong Xue ,  Hongxiang Zhang

    发明人： Narendra Yadav ,  Zhixiong Xue ,  Hongxiang Zhang

    IPC分类号： C12P7/64 ,  C07K14/00 ,  C12N15/12 ,  C40B30/04 ,  C12Q1/48 ,  C12N9/10

    CPC分类号： C12N9/1029 ,  C12P7/6463 ,  C12P7/6472

    摘要： Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil biosynthesis in yeast. Each is expected to play a key role in altering the quantity of polyunsaturated fatty acids produced in oils of oleaginous yeasts.

    摘要翻译： 提供了酰基转移酶，适用于制造含油酵母（例如解脂耶氏酵母）富含ω脂肪酸的微生物油。 具体来说，从解脂耶氏酵母和高山被孢霉中分离出编码二酰基甘油酰基转移酶（DGAT1）的基因。 这些基因编码酵母中参与油生物合成的最终步骤的酶。 预计每一种在改变油质酵母油中产生的多不饱和脂肪酸的量方面起关键作用。

    Delta 15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
    9.
    发明申请
    Delta 15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast 有权
    适用于改变含油植物和酵母中多不饱和脂肪酸水平的Delta 15去饱和酶

    公开(公告)号：US20050132442A1

    公开(公告)日：2005-06-16

    申请号：US10985254

    申请日：2004-11-10

    申请人： Narendra Yadav ,  Hongxiang Zhang

    发明人： Narendra Yadav ,  Hongxiang Zhang

    IPC分类号： A01H1/00 ,  A01H5/00 ,  C07H21/04 ,  C12N20060101 ,  C12N1/18 ,  C12N5/04 ,  C12N9/02 ,  C12N9/04 ,  C12N15/74 ,  C12N15/82 ,  C12P7/64

    CPC分类号： C12N9/0083 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472

    摘要： The present invention relates to fungal Δ-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the Δ-15 fatty acid desaturases are also described herein.

    摘要翻译： 本发明涉及能够催化亚油酸（18:2，LA）转化为α-亚麻酸（18:3，ALA）的真菌Δ-15脂肪酸去饱和酶。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主植物和微生物。 本文还描述了通过过表达Δ-15脂肪酸去饱和酶增加特定ω-3和ω-6脂肪酸的产生的方法。

    Delta-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
    10.
    发明申请
    Delta-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts 有权
    适用于改变含油酵母中多不饱和脂肪酸水平的Delta-12去饱和酶基因

    公开(公告)号：US20050043527A1

    公开(公告)日：2005-02-24

    申请号：US10840325

    申请日：2004-05-06

    申请人： Narendra Yadav ,  Hongxiang Zhang

    发明人： Narendra Yadav ,  Hongxiang Zhang

    IPC分类号： C07H21/04 ,  C12N20060101 ,  C12N9/02 ,  C12P20060101 ,  C12P7/64

    CPC分类号： C12N9/0083

    摘要： The present invention relates to a Δ12 fatty acid desaturase able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturase, nucleic acid sequences that hybridize thereto, DNA constructs comprising the desaturase gene, and recombinant host microorganisms expressing increased levels of the desaturase are described. Methods of increasing production of specific ω-3 and/or ω-6 fatty acids are described by overexpression of the Δ12 fatty acid desaturase or by disruption of the native gene.

    摘要翻译： 本发明涉及能够催化油酸向亚油酸转化的Δ12脂肪酸去饱和酶（LA; 18：2）。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主微生物。 通过Δ12脂肪酸去饱和酶的过表达或天然基因的破坏来描述增加特定ω-3和/或ω-6脂肪酸生产的方法。