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公开(公告)号：US07314595B2
公开(公告)日：2008-01-01
申请号：US10476603
申请日：2002-05-02
IPC分类号： B01L3/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , B01L3/0244 , B01L9/52 , B01L9/523 , B01L2200/025 , B01L2300/0822 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/028 , G01N2035/00158 , G01N2035/00237 , G01N2035/042 , G01N2035/0425 , Y10T436/11
摘要： A system is described for automatic retrieval of microplates from a carousel. The system includes an effector arm that retrieves a selected microplate from the carousel, a microplate retainer that receives the selected microplate from the effector arm, and a controller that directs the effector arm to the carousel for retrieval of the selected microplate and directs the effector arm to the microplate retainer so that it may receive the selected microplate. The carousel may revolve around a vertical axis. A system also is described for washing depositing elements used to spot biological materials on a substrate. Graphical user interfaces also are described for enabling a user to determine which microplates will be used to provide biological probe materials, and in what patterns those probe materials should be deposited on the substrate. The interfaces enable the user to place multiple fractions of biological materials on a same location on a substrate. Also described are graphical user interfaces that present a user with the options to select a first microplate having a plurality of wells, associate at least one probe material with one or more of the wells, and associate one or more locations on one or more substrates with the one or more wells.
摘要翻译： 描述了用于从旋转木马自动检索微孔板的系统。 所述系统包括效应器臂，所述效应器臂从所述圆盘传送带检索选定的微量培养板，从所述效应器臂接收所选微孔板的微孔板保持器，以及将所述效应器臂引导到所述圆盘传送带以取回所选微孔板并引导所述效应臂 到微板保持器，使得其可以接收所选择的微孔板。 圆盘传送带可绕垂直轴旋转。 还描述了用于洗涤沉积用于将基材上的生物材料定位的元件的系统。 还描述了图形用户界面，用于使用户能够确定哪些微孔板将用于提供生物探针材料，以及哪些图案将这些探针材料沉积在基底上。 界面使用户能够将多种生物材料的部分放置在基板上的相同位置上。 还描述了图形用户界面，其向用户呈现选择具有多个孔的第一微孔板的选项，将至少一个探针材料与一个或多个孔相关联，并将一个或多个底物上的一个或多个位置与 一个或多个井。
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2.发明授权System, method, and product for dynamic noise reduction in scanning of biological material 有权用于生物材料扫描的动态降噪的系统，方法和产品公开(公告)号：US07222025B2
公开(公告)日：2007-05-22
申请号：US10973418
申请日：2004-10-27
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B82Y30/00 , B82Y35/00 , C40B50/14 , G01N21/276 , G01N27/44717 , G01N27/44721 , G01N2035/00158 , G01N2035/0494 , G06F19/20
摘要： Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes an excitation signal generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to the at least one representative excitation value based, at least in part, on the normalization factor.
摘要翻译： 描述了用于处理诸如荧光信号的发射信号以补偿诸如激光束的激发光束中的噪声的系统和方法。 作为一个示例，描述了包括激励信号发生器的扫描系统，该激励信号发生器提供具有代表激励波束的一个或多个代表性激励值的激励信号; 提供至少一个激励参考值的激励参考提供器; 归一化因子发生器，其将激励参考值与至少一个代表性激励值进行比较，从而产生归一化因子; 以及比较处理器，其至少部分地基于归一化因子来调整对应于至少一个代表性激励值的至少一个发射值。
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3.发明授权公开(公告)号：US06490533B2
公开(公告)日：2002-12-03
申请号：US09683216
申请日：2001-12-03
IPC分类号： G06F1900
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B82Y30/00 , B82Y35/00 , C40B50/14 , G01N21/276 , G01N27/44717 , G01N27/44721 , G01N2035/00158 , G01N2035/0494 , G06F19/20
摘要： Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes an excitation signal generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to the at least one representative excitation value based, at least in part, on the normalization factor.
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4.发明授权System, method, and product for dynamic noise reduction in scanning of biological materials 有权用于生物材料扫描的动态降噪的系统，方法和产品公开(公告)号：US06813567B2
公开(公告)日：2004-11-02
申请号：US10304092
申请日：2002-11-25
IPC分类号： G06F1900
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B82Y30/00 , B82Y35/00 , C40B50/14 , G01N21/276 , G01N27/44717 , G01N27/44721 , G01N2035/00158 , G01N2035/0494 , G06F19/20
摘要： Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes an excitation signal generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to the at least one representative excitation value based, at least in part, on the normalization factor.
摘要翻译： 描述了用于处理诸如荧光信号的发射信号以补偿诸如激光束的激发光束中的噪声的系统和方法。 作为一个示例，描述了包括激励信号发生器的扫描系统，该激励信号发生器提供具有代表激励波束的一个或多个代表性激励值的激励信号; 提供至少一个激励参考值的激励参考提供器; 归一化因子发生器，其将激励参考值与至少一个代表性激励值进行比较，从而产生归一化因子; 以及比较处理器，其至少部分地基于归一化因子来调整对应于至少一个代表性激励值的至少一个发射值。
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公开(公告)号：US06650411B2
公开(公告)日：2003-11-18
申请号：US09683217
申请日：2001-12-03
IPC分类号： G01J330
CPC分类号： G01N21/6452 , B01J2219/00675 , B01J2219/00677 , B82Y30/00 , B82Y35/00 , C40B50/14 , G01N27/44717 , G01N27/44721 , G01N2035/00158 , G01N2035/0494 , G06F19/20
摘要： Systems and methods are described that may be applied to scanning biological materials in or on probe arrays. For example, a system is described that includes a scanner that has one or more excitation sources and an emission receiving element, such as an objective lens, that receives from locations of the probe array an emission signal responsive to the excitation sources. The scanner also has a radial position generator that generates radial positions of the emission receiving element. Also included in the system is a computer memory having stored therein a plurality of position data, each representing a radial position of the emission receiving element. Also stored in the computer memory unit is a set of comparator instructions that generate a clock signal based, at least in part, on comparing one or more of the plurality of radial positions with one or more of the plurality of position data.
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