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公开(公告)号：US07232805B2
公开(公告)日：2007-06-19
申请号：US10659501
申请日：2003-09-10
CPC分类号： A61K47/551
摘要： The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5′-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells. The conjugate of the invention advantageously provides a reduced systemic toxicity and enhanced efficacy as compared to a corresponding free drug.
摘要翻译： 本发明提供了一种适用于治疗肿瘤相关疾病的钴胺素药物缀合物。 钴胺素通过可裂解连接体和一个或多个任选的间隔物间接共价结合抗肿瘤药物。 钴胺素通过钴胺核糖环的5'-OH共价结合到第一间隔物或可切割的接头。 药物通过药物上现有或添加的官能团与可切割接头的第二间隔物结合。 给药后，缀合物与转钴胺素（其任何同种型）形成复合物。 然后，该复合物与细胞膜上的受体结合，并被吸收到细胞中。 一旦在细胞中，细胞内酶切割缀合物从而释放药物。 根据缀合物的结构，细胞内酶的特定类别或类型影响切割。 由于对生长细胞中钴胺素的高需求，肿瘤细胞通常占有比正常非生长细胞更高的缀合物百分比。 与相应的游离药物相比，本发明的缀合物有利地提供降低的全身毒性和增强的功效。
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公开(公告)号：US20060215765A1
公开(公告)日：2006-09-28
申请号：US11089719
申请日：2005-03-25
申请人： Cherng-Daw Hwang , Steven Wang , Weiping Li
发明人： Cherng-Daw Hwang , Steven Wang , Weiping Li
CPC分类号： H04N7/152 , H04N19/103 , H04N19/162 , H04N19/164 , H04N19/17 , H04N19/40 , H04N19/46 , H04N19/48 , H04N19/70
摘要： A method is described for encoding video. A video sequence is captured at a full frame resolution. Boundaries for an inner region are identified within frames of the video sequence. The video sequence is encoded at the full frame resolution into a bitstream. The bitstream includes a sub-bitstream which encodes for the inner region. Data is embedded within the bitstream. The data identifies the sub-bitstream within the bitstream. In one aspect, the data is a header specifying the inner region. In another aspect, the encoding estimates motion for pixels within the inner region based on pixels within the inner region.
摘要翻译： 描述了一种编码视频的方法。 以全帧分辨率捕获视频序列。 用于内部区域的边界在视频序列的帧内被识别。 视频序列以全帧分辨率编码为比特流。 比特流包括编码内部区域的子比特流。 数据嵌入比特流内。 数据识别比特流内的子比特流。 在一个方面，数据是指定内部区域的标题。 在另一方面，编码基于内部区域内的像素来估计内部区域内的像素的运动。
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3.发明授权公开(公告)号：US06899731B2
公开(公告)日：2005-05-31
申请号：US09750779
申请日：2001-01-02
申请人： Weiping Li , Hai-Quan Mao , Kam W. Leong
发明人： Weiping Li , Hai-Quan Mao , Kam W. Leong
CPC分类号： A61L31/16 , A61L29/16 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2300/802
摘要： A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.
摘要翻译： 公开了用于将哺乳动物体内的治疗剂输送和释放的医疗装置和方法。 在受控吸附技术之后，医疗装置涂覆有带负电的治疗剂和阳离子聚电解质的交替层。 该方法简单，对治疗剂的扰动最小，并且使用临床可接受的生物聚合物例如人血清白蛋白。 通过该技术可以递送的治疗剂的量通过吸收在医疗装置表面上的治疗剂的层数来优化。 在治疗剂和阳离子聚电解质载体的交替层之间存在洗涤步骤，使得可插入医疗装置上的治疗剂的量表示稳定地截留并吸附到医疗装置上的部分。 根据本发明的可插入医疗装置和方法能够将治疗剂可再现地递送到哺乳动物体内的部位，并且允许治疗剂的高度可重现和可控的释放动力学。
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4.发明授权
公开(公告)号：US5940542A
公开(公告)日：1999-08-17
申请号：US743631
申请日：1996-11-04
申请人： Weiping Li , Qinghong Cao , Chun Wang , Kenneth K. Tzeng
发明人： Weiping Li , Qinghong Cao , Chun Wang , Kenneth K. Tzeng
CPC分类号： G06T9/008
摘要： A method and apparatus is disclosed for encoding and decoding an input signal representative of video or audio information. A form of the method includes the following steps: processing the input signal to produce a sequence of vectors representative of the input signal; implementing a lattice vector quantization procedure on individual vectors of the sequence to identify a lattice point of a lattice that is closest to the individual vector and to obtain an index value representative of a labelling of the identified lattice point, the lattice vector quantization procedure including a multi-level allocation of groups of reserved indices, and selection of the index value for the individual vector within a group of reserved indices. The index signals representative of the index values are stored and/or transmitted, and then recovered for decoding. The decoding is operative to obtain a recovered sequence of vectors, and the sequence of vectors can be processed to produce an output signal.
摘要翻译： 公开了一种用于对表示视频或音频信息的输入信号进行编码和解码的方法和装置。 该方法的一种形式包括以下步骤：处理输入信号以产生表示输入信号的向量序列; 对所述序列的各个向量实施格子矢量量化过程，以识别最接近所述个体矢量的格子的格点，并获得表示所识别的格点的标记的索引值，所述格子矢量量化过程包括 保留索引组的多级分配，以及一组保留索引内各个向量的索引值的选择。 表示索引值的索引信号被存储和/或发送，然后被恢复用于解码。 解码操作以获得恢复的向量序列，并且可以处理向量序列以产生输出信号。
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5.发明授权Vector transform coder with multi-layered codebooks and dynamic bit allocation 失效矢量变换编码器与多层码本和动态位分配
公开(公告)号：US5521988A
公开(公告)日：1996-05-28
申请号：US223206
申请日：1994-04-05
申请人： Weiping Li , Ya-Qin Zhang
发明人： Weiping Li , Ya-Qin Zhang
CPC分类号： G06T9/008
摘要： In a vector transform coding (VTC) scheme for image and video compression, a multi-layered codebook structure and a dynamic bit-allocation scheme in the vector transform domain are employed. The main advantage of this technique is that distortion is controlled by dynamically allocating more bits to vectors causing larger distortions and less bits to vectors causing smaller distortions.
摘要翻译： 在用于图像和视频压缩的矢量变换编码（VTC）方案中，采用矢量变换域中的多层码本结构和动态比特分配方案。 该技术的主要优点是通过动态地分配更多的比特来控制失真，所述向量导致较大的失真，并且对于引起较小失真的向量的位数较少。
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公开(公告)号：US20050169969A1
公开(公告)日：2005-08-04
申请号：US11060383
申请日：2005-02-17
申请人： Weiping Li , Hai-Quan Mao , Kam Leong
发明人： Weiping Li , Hai-Quan Mao , Kam Leong
IPC分类号： A61L29/16 , A61L31/16 , A61K48/00 , A61K31/337 , A61K31/4745 , A61M31/00
CPC分类号： A61L31/16 , A61L29/16 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2300/802
摘要： A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.
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公开(公告)号：US20050054607A1
公开(公告)日：2005-03-10
申请号：US10659501
申请日：2003-09-10
申请人： Ned Weinshenker , Frederick West , Barbara Araneo , Weiping Li
发明人： Ned Weinshenker , Frederick West , Barbara Araneo , Weiping Li
IPC分类号： A01N43/04 , A61K20060101 , A61K31/70 , A61K31/714 , A61K47/48
CPC分类号： A61K47/551
摘要： The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5′-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells. The conjugate of the invention advantageously provides a reduced systemic toxicity and enhanced efficacy as compared to a corresponding free drug.
摘要翻译： 本发明提供了一种适用于治疗肿瘤相关疾病的钴胺素药物缀合物。 钴胺素通过可裂解连接体和一个或多个任选的间隔物间接共价结合抗肿瘤药物。 钴胺素通过钴胺核糖环的5'-OH共价结合到第一间隔物或可切割的接头。 药物通过药物上现有或添加的官能团与可切割接头的第二间隔物结合。 给药后，缀合物与转钴胺素（其任何同种型）形成复合物。 然后，该复合物与细胞膜上的受体结合，并被吸收到细胞中。 一旦在细胞中，细胞内酶切割缀合物从而释放药物。 根据缀合物的结构，细胞内酶的特定类别或类型影响切割。 由于对生长细胞中钴胺素的高需求，肿瘤细胞通常占有比正常非生长细胞更高的缀合物百分比。 与相应的游离药物相比，本发明的缀合物有利地提供降低的全身毒性和增强的功效。
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公开(公告)号：US06580834B2
公开(公告)日：2003-06-17
申请号：US08989388
申请日：1997-12-12
申请人： Weiping Li , Fan Ling , Hongqiao Sun
发明人： Weiping Li , Fan Ling , Hongqiao Sun
IPC分类号： G06K936
CPC分类号： H04N19/647
摘要： A method for encoding and decoding an input signal, includes the following steps: applying a transform to the input signal to obtain a transformed signal; quantizing the transformed signal to obtain a sequence of quantized values, the quantized values being representable in the form of ordered binary bits; for each order of said binary bits, encoding a bit plane of the sequence using (run, end) coding to obtain encoded values; and decoding the encoded values to recover the input signal.
摘要翻译： 一种对输入信号进行编码和解码的方法，包括以下步骤：将变换应用于输入信号以获得变换信号; 量化变换的信号以获得量化值序列，量化值可以以有序二进制位的形式表示; 对于所述二进制位的每个顺序，使用（运行，结束）编码对序列的位平面进行编码以获得编码值; 并解码编码值以恢复输入信号。
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9.发明授权公开(公告)号：US09157610B2
公开(公告)日：2015-10-13
申请号：US13579110
申请日：2010-08-25
申请人： Binhai Yu , Bairong Sun , Weiping Li , Xunli Xia , Cheng Li , Menghua Long , Lifang Liang
发明人： Binhai Yu , Bairong Sun , Weiping Li , Xunli Xia , Cheng Li , Menghua Long , Lifang Liang
CPC分类号： F21V21/00 , B23P11/00 , H01L33/486 , H01L33/62 , H01L2224/48247 , H01L2933/0033 , H01L2933/0066 , H05K1/183 , H05K2201/0394 , H05K2201/10106 , Y10T29/49996 , H01L2224/48091 , H01L2924/00014
摘要： A manufacture method for a surface mounted power LED support comprises providing a wiring board having both sided metal layers. In addition, the method comprises forming a hole. Further, the method comprises setting a metal layer in the surface of the hole. Still further, the method comprises thickening the metal layer of the wiring board. The method also comprises etching the metal layer of the wiring board. Moreover, the method comprises cutting the wiring board to form single support unit. A surface mounted power LED support comprises a both sided wiring board, a hole formed in the wiring board and wiring layers set on the surface of the wiring board.
摘要翻译： 一种用于表面贴装电源LED支架的制造方法，包括提供具有双面金属层的布线板。 另外，该方法包括形成孔。 此外，该方法包括在孔的表面设置金属层。 此外，该方法包括使布线板的金属层变厚。 该方法还包括蚀刻布线板的金属层。 此外，该方法包括切割布线板以形成单个支撑单元。 表面安装的功率LED支撑件包括双面布线板，形成在布线板中的孔和设置在布线板表面上的布线层。
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10.发明授权公开(公告)号：US08262250B2
公开(公告)日：2012-09-11
申请号：US12499306
申请日：2009-07-08
申请人： Qing Charles Li , Weiping Li , Qingyue Zuo , Yihang Pan
发明人： Qing Charles Li , Weiping Li , Qingyue Zuo , Yihang Pan
IPC分类号： F21S4/00
CPC分类号： F21V23/06 , F21S4/24 , F21S4/28 , F21V17/007 , F21V21/005 , F21Y2103/10 , F21Y2115/10 , H05K1/189 , H05K2201/10106 , H05K2201/10189
摘要： The present invention relates to lighting strips and more particularly to modular lighting systems comprising lighting devices, for example, lighting strips, physically and electrically connectable with one another by way of a plug and socket integrally formed at opposing ends of the lighting strips. The lighting strip devices can be made of flexible material to allow for applying the lighting devices along flat as well as contoured surfaces. The lighting strips can also be rigid. More particularly, embodiments of the invention include modular lighting strips comprising: a non-conductive substrate strip comprising an electrical circuit; a plurality of light sources operably connected to the electrical circuit; a plug integrally formed at an end of the substrate strip; and a socket integrally formed at an opposing end of the substrate strip; wherein the plug and socket provide for removable, friction-fit, latch or latchless, and electrical interconnection of two or more circuits. Also included in the invention are connector assemblies comprising the inventive socket and plugs integral to PCBs for use in the field of electronics. One or more lighting strip can be combined to form lighting systems, which are useful in many functional and decorative lighting applications. The lighting systems are useful for any residential or commercial application where modular, discrete, low-profile, and/or flexible lighting is desired. The lighting strips of the invention can be used in particular for back lighting, accent lighting, aisle or path lighting, contour lighting, elegant interior decoration, holiday decorations, or landscape lighting.
摘要翻译： 技术领域本发明涉及照明条，更具体地涉及包括照明装置（例如，照明条）的模块化照明系统，所述照明装置通过一体地形成在照明条的相对端处的插头和插座彼此物理上和电气可连接。 照明条装置可以由柔性材料制成，以便沿着平坦和轮廓的表面施加照明装置。 照明条也可以是刚性的。 更具体地，本发明的实施例包括模块化照明条，其包括：包括电路的非导电衬底条; 多个光源，可操作地连接到所述电路; 一体地形成在所述基板条的端部的插塞; 以及一体地形成在所述基板条的相对端部的插座; 其中所述插头和插座提供两个或更多个电路的可移除，摩擦配合，闩锁或闩锁和电互连。 本发明还包括连接器组件，其包括本发明的插座和与电子器件领域中使用的PCB集成的插头。 一个或多个照明条可以组合以形成在许多功能和装饰照明应用中有用的照明系统。 照明系统对于需要模块化，分立，低调和/或柔性照明的住宅或商业应用是有用的。 本发明的照明条特别可用于背光照明，重点照明，通道照明，道路照明，轮廓照明，优雅的室内装饰，假日装饰或景观照明。
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