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1.发明授权Process for the preparation of the lactone of 1R, cis 2,2-dimethyl-3-formyl-cyclopropane-1-carboxylic acid 失效制备1R，顺式2,2-二甲基-3-甲酰基 - 环丙烷-1-羧酸的内酯的方法
公开(公告)号：US5276167A
公开(公告)日：1994-01-04
申请号：US964500
申请日：1992-10-21
IPC分类号： C07D307/32 , C07C27/02 , C07C51/09 , C07C59/29 , C07C62/02 , C07D307/93 , C07D307/00
CPC分类号： C07D307/93
摘要： A process for preparation of a compound of the formula ##STR1##
摘要翻译： 制备式（Ⅰ）化合物的方法
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公开(公告)号：US5312964A
公开(公告)日：1994-05-17
申请号：US68251
申请日：1993-05-27
IPC分类号： A01N53/10 , A01N53/02 , A01N53/04 , A01N53/06 , A01P7/02 , A01P7/04 , C07B41/12 , C07C67/00 , C07C67/14 , C07C67/307 , C07C67/313 , C07C69/743 , C07C69/747 , C07C69/757 , C07C235/06 , C07C253/30 , C07C255/39 , C07C323/19 , C07C327/44 , C07D209/48 , C07D209/49 , C07D307/28 , C07D307/45 , C07C121/75
CPC分类号： C07D209/48 , C07C255/39 , C07C67/307 , C07C67/313 , C07C69/743
摘要： A novel process for the preparation of isomers or mixtures of isomers of compounds of the formula ##STR1## and novel intermediates therefore.
摘要翻译： 用于制备式的化合物的异构体或异构体的混合物的新方法
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公开(公告)号：US5278322A
公开(公告)日：1994-01-11
申请号：US968429
申请日：1992-10-29
IPC分类号： C07D307/32 , C07C51/09 , C07C59/11 , C07C59/29 , C07C62/02 , C07D307/93 , C07D311/02 , C07C61/04
CPC分类号： C07D307/93
摘要： A process for the preparation of a compound of the formula ##STR1## comprising reacting 1R, cis 2,2-dimethyl 3-(2-oxopropyl)-cyclopropane-1-carboxylic acid with an alkali metal, alkaline-earth metal or magnesium hypohalite, and oxidizing the 1R, cis 2,2-dimethyl 3-(hydroxy-carboxy-methyl)-cyclopropane-1-carboxylic acid or its salt or lactonic form thereof thus obtained with an oxidizing agent to obtain the compound of formula I and novel intermediates.
摘要翻译： 一种制备式（I）化合物的方法，包括将1R，顺式2,2-二甲基3-（2-氧代丙基） - 环丙烷-1-羧酸与碱金属，碱土金属 或次卤酸镁，并用氧化剂氧化得到的1R，顺式2,2-二甲基3-（羟基 - 羧基 - 甲基） - 环丙烷-1-羧酸或其盐或内酯形式，得到式 我和新颖的中间体。
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4.发明申请公开(公告)号：US20060135781A1
公开(公告)日：2006-06-22
申请号：US11347630
申请日：2006-02-02
申请人： Jiayao Li , John Link , Colette Colladant
发明人： Jiayao Li , John Link , Colette Colladant
IPC分类号： C07F3/02
CPC分类号： C07D263/56 , C07D277/64 , C07F3/02
摘要： The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors.
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5.发明授权Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds 有权制备烷氧基呋喃酮衍生物的方法，通过所述方法获得的化合物和所述化合物的用途公开(公告)号：US06235899B1
公开(公告)日：2001-05-22
申请号：US09463014
申请日：2000-02-01
IPC分类号： C07D4310
CPC分类号： C07D307/33 , C07K5/1024
摘要： The invention relates to a novel process for preparing compounds of the formula (IV) or (I): from the racemic alkoxyfuranone of the formula (II): R1 and R2 being as defined in the description, to the novel compounds of the formula (IV) as well as to the intermediate compounds of this process, and to the use of the compounds of the formula (IV) or (I) in the process for the synthesis of compounds which inhibit interleukin-1beta converting enzyme.
摘要翻译： 本发明涉及一种制备式（IV）或（I）化合物的新方法：由式（II）的外消旋烷氧基呋喃酮：R1和R2如说明书中所定义，与新的式（ IV）以及该方法的中间体化合物，以及在合成抑制白细胞介素-1β转换酶的化合物的方法中使用式（IV）或（I）的化合物。
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6.发明申请Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride 审中-公开3-β-氨基17-亚甲基雄甾烷-6-α7-β-二醇盐酸盐的结晶形式公开(公告)号：US20080051382A1
公开(公告)日：2008-02-28
申请号：US10575689
申请日：2004-10-20
申请人： Colette Colladant , Denis Prat , Pascal Billot , Alexandre Giuliani , Hagit Elnaleh , Marc-Antoine Perrin
发明人： Colette Colladant , Denis Prat , Pascal Billot , Alexandre Giuliani , Hagit Elnaleh , Marc-Antoine Perrin
IPC分类号： A61K31/565 , A61P29/00 , C07J53/00
CPC分类号： C07J53/00
摘要： The invention relates to novel crystalline forms of 3-beta-amino-17-methylene-androstane-6-alpha,7-beta-diol hydrochloride, referred to as form A, form B and form C, a method for preparing same, the use thereof as a drug, and pharmaceutical compositions containing same.
摘要翻译： 本发明涉及3-β-氨基-17-亚甲基 - 雄甾烷-6-α，7-β-二醇盐酸盐，称为A型，B型和C型的新结晶形式，其制备方法， 作为药物的用途，以及含有它们的药物组合物。
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公开(公告)号：US20050032679A1
公开(公告)日：2005-02-10
申请号：US10867070
申请日：2004-06-14
申请人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
发明人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
CPC分类号： C07K7/56
摘要： A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them.
摘要翻译： 本发明的主题是制备式（I）化合物的方法：R如说明书中所定义，以及它们的盐，中间体，二盐酸盐作为药物的用途以及含有它们的药物组合物 。
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公开(公告)号：US20100273977A1
公开(公告)日：2010-10-28
申请号：US12830941
申请日：2010-07-06
申请人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
发明人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
IPC分类号： C07K7/56
CPC分类号： C07K7/56
摘要： A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them. The process for preparing formula (I) leads to greater than 50% yield of isomer A, and its intended use, e.g. as an antifungal medicament.
摘要翻译： 本发明的主题是制备式（I）化合物的方法：R如说明书中所定义，以及它们的盐，中间体，二盐酸盐作为药物的用途以及含有它们的药物组合物 。 制备式（I）的方法导致异构体A的产率大于50％，并且其预期用途，例如， 作为抗真菌药物。
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公开(公告)号：US20070105760A1
公开(公告)日：2007-05-10
申请号：US11591898
申请日：2006-11-02
申请人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
发明人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
CPC分类号： C07K7/56
摘要： A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them. The process for preparing formula (I) leads to greater than 50% yield of isomer A, and its intended use, e.g. as an antifungal medicament.
摘要翻译： 本发明的主题是制备式（I）化合物的方法：R如说明书中所定义，以及它们的盐，中间体，二盐酸盐作为药物的用途以及含有它们的药物组合物 。 制备式（I）的方法导致异构体A的产率大于50％，并且其预期用途，例如， 作为抗真菌药物。
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公开(公告)号：US07148322B2
公开(公告)日：2006-12-12
申请号：US10867070
申请日：2004-06-14
申请人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
发明人： Philippe Boffelli , Agnes Brouillard , Colette Colladant , Serge Droux , Michel Elter , Didier Ferroud , Guy Lemaitre , Joseph Paladino
CPC分类号： C07K7/56
摘要： A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them. The process for preparing formula (I) leads to greater than 50% yields of isomer A, and its intended use, e.g. as an antifungal medicament.
摘要翻译： 本发明的主题是制备式（I）化合物的方法：R如说明书中所定义，以及它们的盐，中间体，二盐酸盐作为药物的用途以及含有它们的药物组合物 。 制备式（I）的方法导致异构体A的产率大于50％，其预期用途，例如， 作为抗真菌药物。
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