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公开(公告)号：US20090156519A1
公开(公告)日：2009-06-18
申请号：US10584378
申请日：2004-12-23
CPC分类号： A61K48/005 , C07K14/4746 , C07K14/705 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2799/023
摘要： The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer.
摘要翻译： 本发明涉及编码多肽的核酸以及核酸或多肽在预防和/或治疗癌症中的用途。 特别地，本发明涉及用于插入和表达用于癌症免疫治疗中的编码肿瘤抗原的外源基因的改良载体。
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公开(公告)号：US20060127360A1
公开(公告)日：2006-06-15
申请号：US10933874
申请日：2004-09-03
IPC分类号： A61K48/00 , C12N15/863
CPC分类号： G01N33/5743 , A61K39/0011 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2799/023
摘要： The present invention relates to peptides, polypeptides, and nucleic acids and the use of the peptide, polypeptide or nucleic acid in preventing and/or treating cancer. In particular, the invention relates to peptides and nucleic acid sequences encoding such peptides for use in diagnosing, treating, or preventing melanoma.
摘要翻译： 本发明涉及肽，多肽和核酸，以及肽，多肽或核酸在预防和/或治疗癌症中的用途。 特别地，本发明涉及编码这种肽用于诊断，治疗或预防黑素瘤的肽和核酸序列。
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公开(公告)号：US08911991B2
公开(公告)日：2014-12-16
申请号：US10933874
申请日：2004-09-03
IPC分类号： C12N15/63 , G01N33/574 , A61K39/00
CPC分类号： G01N33/5743 , A61K39/0011 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2799/023
摘要： The present invention relates to peptides, polypeptides, and nucleic acids and the use of the peptide, polypeptide or nucleic acid in preventing and/or treating cancer. In particular, the invention relates to peptides and nucleic acid sequences encoding such peptides for use in diagnosing, treating, or preventing melanoma.
摘要翻译： 本发明涉及肽，多肽和核酸，以及肽，多肽或核酸在预防和/或治疗癌症中的用途。 特别地，本发明涉及编码这种肽用于诊断，治疗或预防黑素瘤的肽和核酸序列。
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公开(公告)号：US20070110718A1
公开(公告)日：2007-05-17
申请号：US10579007
申请日：2004-11-12
申请人： Dennis Panicali , Gail Mazzara , Linda Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James Hodge
发明人： Dennis Panicali , Gail Mazzara , Linda Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James Hodge
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K39/0011 , A61K48/005 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , C12N7/00 , C12N2710/24043 , C12N2710/24071 , C12N2710/24143 , C12N2710/24171 , C12N2799/023
摘要： The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.
摘要翻译： 本发明涉及用于治疗患有或患有乳腺癌的个体的系统。 该系统包括向个体施用重组痘病毒，其中痘病毒含有编码至少一种乳腺癌抗原的外源核酸。
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公开(公告)号：US20060159706A1
公开(公告)日：2006-07-20
申请号：US10543944
申请日：2004-02-20
IPC分类号： A61K39/275 , C12N7/00 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , C12N2710/24043 , C12N2710/24143 , Y02A50/412
摘要： The present invention provides novel insertion sites for introducing DNA into pox vectors.
摘要翻译： 本发明提供了将DNA引入痘痘载体的新的插入位点。
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公开(公告)号：US07118738B2
公开(公告)日：2006-10-10
申请号：US10057136
申请日：2002-01-25
申请人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
发明人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
CPC分类号： C12Q1/6897 , A61K39/00 , C07K14/4727 , C07K14/705 , C07K14/70532 , C12N2799/021 , C12N2799/023 , C12Q1/6883 , C12Q1/6886
摘要： Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.
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公开(公告)号：US08562970B2
公开(公告)日：2013-10-22
申请号：US10575060
申请日：2004-10-06
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/5256 , C12N2799/023
摘要： The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer.
摘要翻译： 本发明涉及编码多肽的核酸以及核酸或多肽在预防和/或治疗癌症中的用途。 特别地，本发明涉及用于插入和表达用于癌症免疫治疗中的编码肿瘤抗原的外源基因的改良载体。
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公开(公告)号：US20080113928A1
公开(公告)日：2008-05-15
申请号：US10575060
申请日：2004-10-06
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/5256 , C12N2799/023
摘要： The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer.
摘要翻译： 本发明涉及编码多肽的核酸以及核酸或多肽在预防和/或治疗癌症中的用途。 特别地，本发明涉及用于插入和表达用于癌症免疫治疗中的编码肿瘤抗原的外源基因的改良载体。
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