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    TAT-036 and methods of assessing and treating cancer
    3.
    发明申请
    TAT-036 and methods of assessing and treating cancer 审中-公开
    TAT-036以及评估和治疗癌症的方法

    公开(公告)号：US20070186295A1

    公开(公告)日：2007-08-09

    申请号：US11657313

    申请日：2007-01-24

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  A61K39/00 ,  A61K48/00 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C07K16/32 ,  A61K39/0011 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N33/57423 ,  G01N33/57492 ,  G01N33/6884

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-036 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-036 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-036 expression or activity, comprising: contacting a candidate compound with a TAT-036 and detecting the presence or absence of binding between said compound and said TAT-036, or detecting a change in TAT-036 expression or activity. Methods are also included for the identification of compounds that modulate TAT-036 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-036 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-036蛋白的表达与癌相关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-036与异常发育和生长相关，并且可用作鉴定抗癌化合物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-036表达或活性的化合物的方法，其包括：使候选化合物与TAT-036接触并检测所述化合物与所述TAT-036之间是否存在结合，或 检测TAT-036表达或活性的变化。 还包括用于鉴定调节TAT-036表达或活性的化合物的方法，包括：向细胞或细胞群施用化合物，以及检测TAT-036表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

    TAT-041 and methods of assessing and treating cancer
    4.
    发明申请
    TAT-041 and methods of assessing and treating cancer 审中-公开
    TAT-041和评估和治疗癌症的方法

    公开(公告)号：US20070269434A1

    公开(公告)日：2007-11-22

    申请号：US11700378

    申请日：2007-01-31

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A61K39/395 ,  A61K48/00 ,  C07H21/00 ,  C07K16/18 ,  C12N5/06 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-041 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-041 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-041 expression or activity, comprising: contacting a candidate compound with a TAT-041 and detecting the presence or absence of binding between said compound and said TAT-041, or detecting a change in TAT-041 expression or activity. Methods are also included for the identification of compounds that modulate TAT-041 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-041 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现人类患者中TAT-041蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-041与异常发育和生长相关，并且可用作鉴定抗癌化合物（包括用于免疫治疗的抗体）的靶标。 因此，本发明提供了用于鉴定抑制TAT-041表达或活性的化合物的方法，其包括：使候选化合物与TAT-041接触并检测所述化合物与所述TAT-041之间是否存在结合，或 检测TAT-041表达或活性的变化。 还包括用于鉴定调节TAT-041表达或活性的化合物的方法，包括：向细胞或细胞群施用化合物，以及检测TAT-041表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

    TAT-044 and methods of assessing and treating cancer
    5.
    发明申请
    TAT-044 and methods of assessing and treating cancer 审中-公开
    TAT-044和评估和治疗癌症的方法

    公开(公告)号：US20070192886A1

    公开(公告)日：2007-08-16

    申请号：US11699785

    申请日：2007-01-30

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A01K67/027 ,  G01N33/574 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K39/00 ,  A61K48/00

    CPC分类号： G01N33/57423 ,  A61K39/00 ,  C07K14/4748 ,  C07K16/32 ,  G01N2500/00

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-044 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-044 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-044 expression or activity, comprising: contacting a candidate compound with a TAT-044 and detecting the presence or absence of binding between said compound and said TAT-044, or detecting a change in TAT-044 expression or activity. Methods are also included for the identification of compounds that modulate TAT-044 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-044 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-044蛋白的表达与癌症相关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-044与异常发育和生长有关，可用作鉴定抗癌化合物（包括用于免疫治疗的抗体）的靶标。 因此，本发明提供了用于鉴定抑制TAT-044表达或活性的化合物的方法，其包括：使候选化合物与TAT-044接触并检测所述化合物与所述TAT-044之间是否存在结合，或 检测TAT-044表达或活性的变化。 还包括用于鉴定调节TAT-044表达或活性的化合物的方法，包括：向细胞或细胞群施用化合物，并检测TAT-044表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

    TAT-042 and methods of assessing and treating cancer
    6.
    发明申请
    TAT-042 and methods of assessing and treating cancer 审中-公开
    TAT-042以及评估和治疗癌症的方法

    公开(公告)号：US20070192887A1

    公开(公告)日：2007-08-16

    申请号：US11699833

    申请日：2007-01-30

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  A61K39/395 ,  A61K39/00 ,  C07K14/82 ,  C07K16/30 ,  A61K48/00

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  G01N33/57423

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-042 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-042 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-042 expression or activity, comprising: contacting a candidate compound with a TAT-042 and detecting the presence or absence of binding between said compound and said TAT-042, or detecting a change in TAT-042 expression or activity. Methods are also included for the identification of compounds that modulate TAT-042 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-042 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现人类患者中TAT-042蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-042与异常发育和生长相关，并且可用作鉴定抗癌化合物（包括用于免疫治疗的抗体）的靶标。 因此，本发明提供了鉴定抑制TAT-042表达或活性的化合物的方法，包括：使候选化合物与TAT-042接触，并检测所述化合物与所述TAT-042之间是否存在结合，或 检测TAT-042表达或活性的变化。 还包括用于鉴定调节TAT-042表达或活性的化合物的方法，包括：向细胞或细胞群施用化合物，并检测TAT-042表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

    TAT-028 and methods of assessing and treating cancer
    7.
    发明申请
    TAT-028 and methods of assessing and treating cancer 审中-公开
    TAT-028以及评估和治疗癌症的方法

    公开(公告)号：US20070192883A1

    公开(公告)日：2007-08-16

    申请号：US11655858

    申请日：2007-01-19

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395 ,  A61K48/00 ,  A61K39/00 ,  C07K14/82 ,  C07K16/30

    CPC分类号： G01N33/57423 ,  A01K2217/05 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/57492 ,  G01N2500/00

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-028 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-028 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-028 expression or activity, comprising: contacting a candidate compound with a TAT-028 and detecting the presence or absence of binding between said compound and said TAT-028, or detecting a change in TAT-028 expression or activity. Methods are also included for the identification of compounds that modulate TAT-028 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-028 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现人类患者中TAT-028蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-028与异常发育和生长相关，并且可用作鉴定抗癌化合物（包括用于免疫治疗的抗体）的靶标。 因此，本发明提供了用于鉴定抑制TAT-028表达或活性的化合物的方法，包括：使候选化合物与TAT-028接触并检测所述化合物与所述TAT-028之间是否存在结合，或 检测TAT-028表达或活性的变化。 还包括用于鉴定调节TAT-028表达或活性的化合物的方法，包括：向细胞或细胞群体施用化合物，以及检测TAT-028表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

    TAT-046 and methods of assessing and treating cancer
    10.
    发明申请
    TAT-046 and methods of assessing and treating cancer 审中-公开
    TAT-046以及评估和治疗癌症的方法

    公开(公告)号：US20070220620A1

    公开(公告)日：2007-09-20

    申请号：US11700590

    申请日：2007-01-31

    申请人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    发明人： Daniel Chelsky ,  Paul Kearney ,  Eustache Paramithiotis ,  Lyes Hamaidi ,  Leslie Kondejewski ,  Joel Lanoix ,  Patrice Hugo

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/574 ,  A61K48/00 ,  C07K16/30 ,  C07K14/82 ,  C12P21/06

    CPC分类号： G01N33/57423 ,  A61K39/00 ,  C07K14/4748 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： Surprisingly, the present inventors have discovered that expression of TAT-046 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-046 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-046 expression or activity, comprising: contacting a candidate compound with a TAT-046 and detecting the presence or absence of binding between said compound and said TAT-046, or detecting a change in TAT-046 expression or activity. Methods are also included for the identification of compounds that modulate TAT-046 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-046 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

    摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-046蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-046与异常发育和生长相关，并且可用作鉴定抗癌化合物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-046表达或活性的化合物的方法，包括：使候选化合物与TAT-046接触并检测所述化合物与所述TAT-046之间是否存在结合，或 检测TAT-046表达或活性的变化。 还包括用于鉴定调节TAT-046表达或活性的化合物的方法，包括：向细胞或细胞群施用化合物，以及检测TAT-046表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。