公开(公告)号：US20080242694A1

公开(公告)日：2008-10-02

申请号：US11901598

申请日：2007-09-17

申请人： Neil R. D'Sidocky ,  Roy L. Harris ,  Sayee G. Hegde ,  Robert Hilgraf ,  Margaret A. McCarrick ,  Jeffrey A. McKie ,  Deborah S. Mortensen ,  Lisa Nadolny ,  Sophie M. Perin-Ninkovic ,  John J. Sapienza ,  Jonathan L. Wright

发明人： Neil R. D'Sidocky ,  Roy L. Harris ,  Sayee G. Hegde ,  Robert Hilgraf ,  Margaret A. McCarrick ,  Jeffrey A. McKie ,  Deborah S. Mortensen ,  Lisa Nadolny ,  Sophie M. Perin-Ninkovic ,  John J. Sapienza ,  Jonathan L. Wright

IPC分类号： A61K31/4375 ,  C07D417/04 ,  A61P35/00 ,  A61K31/4725

CPC分类号： C07D417/04 ,  C07D285/135 ,  C07D403/04 ,  C07D417/14

摘要： Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂环化合物：其中R 1，R 2，X，Y和Z如本文所定义，组合物包含有效量的杂环化合物 以及用于治疗或预防癌症，炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症的方法，包括向有需要的患者施用有效量的杂环化合物。

公开(公告)号：US07723340B2

公开(公告)日：2010-05-25

申请号：US11332617

申请日：2006-01-12

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61F2/82 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。

公开(公告)号：US08101588B2

公开(公告)日：2012-01-24

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  C07F5/02 ,  A61K31/52 ,  A61K31/69 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US20090312320A1

公开(公告)日：2009-12-17

申请号：US12540013

申请日：2009-08-12

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

IPC分类号： A61K31/52 ,  A61K31/5377 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。

公开(公告)号：US20090275564A1

公开(公告)日：2009-11-05

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S.S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/16 ,  C07D413/14 ,  C07D243/08 ,  A61K31/5377 ,  A61K31/551 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US07521446B2

公开(公告)日：2009-04-21

申请号：US11411413

申请日：2006-04-26

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US20060287344A1

公开(公告)日：2006-12-21

申请号：US11332617

申请日：2006-01-12

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的 氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US20130029987A1

公开(公告)日：2013-01-31

申请号：US13451574

申请日：2012-04-20

申请人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

发明人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

IPC分类号： A61K31/505 ,  C07D405/12 ,  C07D401/12 ,  A61K31/506 ,  C07D405/14 ,  C12N5/071 ,  C07D413/12 ,  A61K31/5377 ,  A61P1/16 ,  A61P3/10 ,  A61P3/00 ,  C07D239/48 ,  C07D403/12

CPC分类号： C07D239/48 ,  A61K31/505 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

公开(公告)号：US08158635B2

公开(公告)日：2012-04-17

申请号：US12200146

申请日：2008-08-28

申请人： Marie G. Beauchamps ,  Louise Michelle Cameron ,  Robert Hilgraf ,  Mohit Atul Kothare ,  Manohar T. Saindane ,  Jean Xu

发明人： Marie G. Beauchamps ,  Louise Michelle Cameron ,  Robert Hilgraf ,  Mohit Atul Kothare ,  Manohar T. Saindane ,  Jean Xu

IPC分类号： C07D473/32 ,  A61K31/52

CPC分类号： C07D487/04

摘要： Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9H-purin-2-ylamino]-cyclohexan-1-ol, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.

摘要翻译： 包含4- [9-（四氢 - 呋喃-3-基）-8-（2,4,6-三氟 - 苯基氨基）-9H-嘌呤-2-基氨基] - 环己烷-1-醇的固体形式包含 公开了固体形式，制备固体形式的方法及其用于治疗各种疾病和/或病症的方法。