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公开(公告)号：US4879114A
公开(公告)日：1989-11-07
申请号：US811505
申请日：1985-12-20
IPC分类号： A61K35/44 , A61K8/00 , A61K8/33 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/73 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/98 , A61K31/00 , A61K35/37 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/10
CPC分类号： A61K35/37 , A61K31/00 , A61K8/925 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q5/02 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847
摘要： 36 Lipid extracts and lipid fractions from mammalian omenta containing mostly lipids are used cosmetically for skin conditions, skin care and cosmetic products which products have skin softening applications without skin irritation, greasiness or mutagenic effect. These materials with and without ganglioside are used for skin conditions such as keratosis, white spots and the like.
摘要翻译： 36来自主要为脂质的哺乳动物网膜的脂质提取物和脂质部分用于化妆品用于皮肤状况，皮肤护理和化妆品，该产品具有皮肤柔软应用，无皮肤刺激，油腻或诱变作用。 具有和不含神经节苷脂的这些材料用于皮肤状况如角化病，白点等。
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公开(公告)号：US4957741A
公开(公告)日：1990-09-18
申请号：US227533
申请日：1988-08-02
CPC分类号： A61K35/30 , A61K31/00 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Lipid material or ganglioside from mammalian sources e.g. bovine and porcine brain or omentum is used to treat peptic ulcers.
摘要翻译： 来自哺乳动物来源的脂质物质或神经节苷脂 牛和猪脑或网膜用于治疗消化性溃疡。
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3.发明授权Composition and method for treatment of gastric and duodenal ulcers and mucosal erosions 失效用于治疗胃和十二指肠溃疡和粘膜糜烂的组合物和方法
公开(公告)号：US5066496A
公开(公告)日：1991-11-19
申请号：US227739
申请日：1988-08-03
申请人： Sandor Szabo , Meryl S. A. Rubin , Michael Klibaner , Ahmad R. Kamarei , Robert S. Sinn , Nicholas Catsimpoolas
发明人： Sandor Szabo , Meryl S. A. Rubin , Michael Klibaner , Ahmad R. Kamarei , Robert S. Sinn , Nicholas Catsimpoolas
CPC分类号： A61K31/7032 , A61K35/30 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Ganglioside mixtures and/or lipid mixtures e.g. from brain and omentum, are found to be effective to treat peptic ulcers.
摘要翻译： 神经节苷脂混合物和/或脂质混合物 发现脑和网膜被发现有效治疗消化性溃疡。
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4.发明授权
公开(公告)号：US4921838A
公开(公告)日：1990-05-01
申请号：US62962
申请日：1987-06-16
IPC分类号： A61K31/14 , A61K31/21 , A61K31/575 , A61K31/70 , A61K31/765
CPC分类号： A61K31/685 , A61K31/14 , A61K31/21 , A61K31/575 , A61K31/70 , A61K31/704 , A61K31/765
摘要： A method for enhancing angiogenesis and/or blood vascular perfusion in mammals by administering a pharmacologically effective amount of specific angiogenically active non-ionic, anionic, cationic and zwitterionic amphiphilic compounds. An angiogenically effective amount of the angiogenically active compound digitonin is in the range of at least 1.25 microgram to at least 200 microgram of digitonin. The range including enhancement of vascular perfusion is up to 50 mg of digitonin.
摘要翻译： 一种通过施用药理学有效量的特异性血管生成活性非离子，阴离子，阳离子和两性离子两亲化合物来增强哺乳动物血管生成和/或血管血管灌注的方法。 血管生成有效量的血管生成活性化合物雌二醇在至少1.25微克至至少200微升的苦参蛋白的范围内。 血管灌注增强的范围高达50mg。
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5.发明授权Compositions containing ganglioside molecules with enhanced angiogenic activity 失效含有增加血管生成活性的神经节苷脂分子的组合物
公开(公告)号：US4710490A
公开(公告)日：1987-12-01
申请号：US782724
申请日：1985-10-01
IPC分类号： A61K38/00 , A61K31/00 , A61K31/685 , A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/12 , A61K35/37 , A61K35/38 , C07H15/10
CPC分类号： A61K31/685 , A61K31/00 , A61K31/70 , A61K31/715 , A61K35/38
摘要： Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.
摘要翻译： 公开了含有具有血管生成活性的含脂分子的组合物。 含有脂质的分子已经在各种动物的哺乳动物组织，特别是网膜中发现。 此外，已知的脂质，例如神经节苷脂，意外地被发现具有血管生成活性。 公开了一种用于获得网膜衍生的脂质以及用于这些和已知脂质的方法。
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公开(公告)号：US4990333A
公开(公告)日：1991-02-05
申请号：US811894
申请日：1985-12-20
摘要： Factors isolated from omental extracts are used to promote bone healing, for example in fractures in mammals.
摘要翻译： 从网膜提取物分离的因子用于促进骨愈合，例如在哺乳动物的骨折中。
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公开(公告)号：US4888324A
公开(公告)日：1989-12-19
申请号：US116014
申请日：1987-11-02
IPC分类号： A61K31/00 , A61K31/70 , A61K31/715 , A61K35/12 , A61K35/37
CPC分类号： A61K31/685 , A61K31/00 , A61K31/70 , A61K31/715
摘要： Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.
摘要翻译： 公开了含有具有血管生成活性的含脂分子的组合物。 含有脂质的分子已经在各种动物的哺乳动物组织，特别是网膜中发现。 此外，已知的脂质，例如神经节苷脂，意外地被发现具有血管生成活性。 公开了一种用于获得网膜衍生的脂质以及用于这些和已知脂质的方法。
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公开(公告)号：US4769362A
公开(公告)日：1988-09-06
申请号：US852444
申请日：1986-04-14
IPC分类号： A61K38/00 , A61K31/00 , A61K31/70 , A61K31/715 , A61K35/12 , A61K35/37 , A61P7/00 , A61P9/14 , C07H15/10
CPC分类号： C07H15/10 , A61K31/00 , A61K31/685 , A61K31/70 , A61K31/715 , A61K35/38
摘要： Lipid containing molecules and compositions, including gangliosides and omental tissue extracts had previously been found to be effective in increasing angiogenesis. It has now been found that these same materials cause increased localized perfusion in mammals. A method for providing increased perfusion, using these compositions, is presented herein.
摘要翻译： 包含神经节苷脂和网膜组织提取物的含脂分子和组合物以前已被发现在增加血管发生中是有效的。 现在已经发现，这些相同的材料导致哺乳动物局部灌注增加。 本文给出了使用这些组合物提供增加灌注的方法。
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公开(公告)号：US4767746A
公开(公告)日：1988-08-30
申请号：US805206
申请日：1985-12-04
IPC分类号： A61K35/44 , A61K31/00 , A61K35/37 , A61K38/00 , C07H15/10 , A61K31/70 , A61K31/20 , A61K31/715
CPC分类号： A61K31/00 , A61K35/37 , Y10S424/13
摘要： Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.
摘要翻译： 网膜脂质部分加速伤口愈合，特别是哺乳动物的上皮形成。
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10.发明授权
公开(公告)号：US4699788A
公开(公告)日：1987-10-13
申请号：US642624
申请日：1984-08-20
摘要： A novel angiogenic composition obtained from the omentum is provided which acts as a potent and effective factor for blood perfusion enhancement and for the development of new blood vessels in an organized structural network in living tissues. The angiogenic composition is a lipid or lipids, essentially protein-free as extracted from the omentum using organic solvents. This composition can then be injected to target to a site where new blood vessel formation, or blood perfusion enhancement is required. This material can be used to heal various damaged tissues including bone and heart.
摘要翻译： 提供从网膜获得的新型血管生成组合物，其作为血液灌注增强的有效和有效因素，并且用于在活组织中有组织的结构网络中新血管的发育。 血管生成组合物是使用有机溶剂从网膜提取的基本上不含蛋白质的脂质或脂质。 然后可以将该组合物注射到需要新血管形成或需要血液灌注增强的部位。 该材料可用于治疗各种损伤的组织，包括骨骼和心脏。
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