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    Thermoplastic blends and articles made therefrom
    1.
    发明申请
    Thermoplastic blends and articles made therefrom 审中-公开
    热塑性混合物和由其制成的制品

    公开(公告)号：US20060235117A1

    公开(公告)日：2006-10-19

    申请号：US11175242

    申请日：2005-07-06

    申请人： Nicola Cont ,  Bo Liu ,  Xiaomin Zhang ,  Jayantha Amarasekera

    发明人： Nicola Cont ,  Bo Liu ,  Xiaomin Zhang ,  Jayantha Amarasekera

    IPC分类号： C08K5/49

    CPC分类号： C08L67/02 ,  C08K3/22 ,  C08K5/0066 ,  C08L23/0846 ,  C08L23/0884 ,  C08L51/06 ,  C08L69/00 ,  C08L2666/02

    摘要： An internally lubricated thermoplastic composition consisting essentially of 5 to 50 wt. % of a polycarbonate; 35 to 90 wt. % of a polyalkylene terephthalate, a polyalkylene naphthanoate resin, or blends thereof; 0.5 to 4 wt. % of a modified polyolefin; and optionally, up to 30 wt. % of a flame retardant agent, with a balanced fatigue and dimensional stability properties. Articles molded from the composition of the invention display excellent wear performance properties.

    摘要翻译： 一种内部润滑的热塑性组合物，其基本上由5至50wt。 ％的聚碳酸酯; 35〜90重量％ ％的聚对苯二甲酸亚烷基酯，聚亚烷基二氢萘酯树脂或其共混物; 0.5〜4重量％ ％的改性聚烯烃; 和任选地，至多30wt。 ％的阻燃剂，具有平衡的疲劳和尺寸稳定性。 由本发明组合物成型的制品表现出优异的耐磨性能。

    Dihydroindolinone derivatives
    3.
    发明授权
    Dihydroindolinone derivatives 有权
    二氢吲哚啉酮衍生物

    公开(公告)号：US08829039B2

    公开(公告)日：2014-09-09

    申请号：US12994442

    申请日：2009-05-25

    申请人： Zhedong Yuan ,  Xiaomin Zhang ,  Hubo Wang ,  Xueyan Zhu ,  Hongjiang Xu ,  Hui Fu ,  Wei Song

    发明人： Zhedong Yuan ,  Xiaomin Zhang ,  Hubo Wang ,  Xueyan Zhu ,  Hongjiang Xu ,  Hui Fu ,  Wei Song

    IPC分类号： A61K31/33 ,  C07D209/10 ,  C07D403/06

    CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14

    摘要： Disclosed are dihydroindolone compounds which can modulate the activity of protein tyrosine kinases, a method for preparing the same, and pharmaceutical compositions comprising the same. Also disclosed are use of such compounds and pharmaceutical compositions thereof in the treatment and/or prophylaxis of protein tyrosine kinase associated diseases in an organism, particularly in the treatment and/or prophylaxis of tumors and fibroblast proliferation associated diseases.

    摘要翻译： 公开了可以调节蛋白酪氨酸激酶活性的二氢吲哚酮化合物，其制备方法和包含其的药物组合物。 还公开了这样的化合物及其药物组合物用于治疗和/或预防生物体中蛋白质酪氨酸激酶相关疾病的用途，特别是治疗和/或预防肿瘤和成纤维细胞增殖相关疾病。

    Absorbent materials and absorbent articles incorporating such absorbent materials
    5.
    发明授权
    Absorbent materials and absorbent articles incorporating such absorbent materials 有权
    吸收材料和吸收性物品

    公开(公告)号：US08269060B2

    公开(公告)日：2012-09-18

    申请号：US12636440

    申请日：2009-12-11

    申请人： Jian Qin ,  Xiaomin Zhang ,  Debra Ann Graverson

    发明人： Jian Qin ,  Xiaomin Zhang ,  Debra Ann Graverson

    IPC分类号： A61F13/15 ,  A61F13/20

    CPC分类号： A61L15/60 ,  Y10S522/909

    摘要： An absorbent material formed at least in part of a crosslinked polymer. The absorbent material has a centrifuge retention capacity as determined by a Centrifuge Retention Capacity Test of at least about 20 g/g and a gel bed permeability under load as determined by a Gel Bed Permeability Under Load Test of at least about 300×10−9 cm2 or a free swell gel bed permeability as determined by a Free Swell Gel Bed Permeability Test of at least about 2,500×10−9 cm2. The crosslinked polymer may comprise either at least about 75 weight percent anionic polymer or at least about 75 weight percent cationic polymer. In one embodiment, the cross-linked polymer is surface treated with a water soluble non-cross-linked polymer having a potential for becoming charged opposite that of the cross-linked polymer.

    摘要翻译： 至少部分形成交联聚合物的吸收材料。 吸收材料具有通过离心保留容量试验测定的至少约20g / g的离心保留能力和通过凝胶渗透性负载试验测定的凝胶渗透性在至少约300×10-9 cm 2或通过自由溶胀凝胶床渗透性试验测定的自由溶胀凝胶层渗透性为至少约2,500×10 -9 cm 2。 交联聚合物可以包含至少约75重量％的阴离子聚合物或至少约75重量％的阳离子聚合物。 在一个实施方案中，交联聚合物用具有与交联聚合物相反的电位的水溶性非交联聚合物进行表面处理。

    P49/STRAP is a novel protein involved in gene regulation and cell proliferation
    6.
    发明申请
    P49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权

    公开(公告)号：US20090035850A1

    公开(公告)日：2009-02-05

    申请号：US12283347

    申请日：2008-09-11

    申请人： Jeanne Y. Wei ,  Xiaomin Zhang

    发明人： Jeanne Y. Wei ,  Xiaomin Zhang

    IPC分类号： C12N5/10 ,  C07H21/04

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.

    Stretchable absorbent composite with low superaborbent shake-out
    7.
    发明申请
    Stretchable absorbent composite with low superaborbent shake-out 有权
    具有低超吸收剂振动的可拉伸吸收复合材料

    公开(公告)号：US20060004336A1

    公开(公告)日：2006-01-05

    申请号：US10883174

    申请日：2004-06-30

    申请人： Xiaomin Zhang ,  David Jackson ,  Lisa Jacobsen ,  Jian Qin ,  Dave Soerens

    发明人： Xiaomin Zhang ,  David Jackson ,  Lisa Jacobsen ,  Jian Qin ,  Dave Soerens

    IPC分类号： A61F13/15

    CPC分类号： A61L15/60

    摘要： An article comprises a stretchable absorbent composite (30) that includes a quantity of superabsorbent particles (32) which are operatively contained within a matrix of elastomeric polymer fibers (34). In particular aspects, the composite article can include at least about 60 wt % of the superabsorbent particles and not more than about 40 wt % of the elastomeric polymer fibers, based on a total weight of the composite. In other aspects, the composite article can provide a high stretchability. Additional aspects can provide a low shake-out. Particular configurations can, for example, provide a stretchability value of at least about 30%. Additional aspects can include a configuration that provides a shake-out value of not more than about 2%. In other aspects, the invention can provide a shake-out value of not more than about 1.2%. In further aspects, the absorbent composite can include superabsorbent particles having a coating of treatment-material that is thermally processible. Additional aspects can include a treatment-material which is water soluble.

    摘要翻译： 一种制品包括可拉伸吸收复合材料（30），其包括一定量的超吸收颗粒（32），其可操作地包含在弹性体聚合物纤维（34）的基体内。 在具体方面，基于复合材料的总重量，复合制品可以包括至少约60重量％的超吸收颗粒和不超过约40重量％的弹性体聚合物纤维。 在其它方面，复合制品可以提供高的拉伸性。 其他方面可以提供低抖动。 具体的配置可以例如提供至少约30％的拉伸性值。 另外的方面可以包括提供不大于约2％的振荡值的配置。 在其它方面，本发明可以提供不超过约1.2％的振荡值。 在另外的方面，吸收性复合材料可以包括具有热处理材料的涂层的超吸收颗粒。 另外的方面可以包括水溶性的处理材料。

    p49/STRAP is a novel protein involved in gene regulation and cell proliferation
    9.
    发明授权
    p49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权
    p49 / STRAP是一种涉及基因调控和细胞增殖的新型蛋白质

    公开(公告)号：US08232098B2

    公开(公告)日：2012-07-31

    申请号：US12283347

    申请日：2008-09-11

    申请人： Jeanne Y. Wei ,  Xiaomin Zhang

    发明人： Jeanne Y. Wei ,  Xiaomin Zhang

    IPC分类号： C12N15/00 ,  C07H21/02

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.

    摘要翻译： 本发明提供分离的p49 / STRAP蛋白和编码p49 / STRAP蛋白的分离的核酸。 本发明人发现了一种新的蛋白质，命名为p49 / STRAP，其在哺乳动物的心脏组织和其他组织中表达。 p49 / STRAP蛋白与血清反应因子（SRF）结合并调节心脏中SRF反应基因的转录。 还发现p49 / STRAP抑制肿瘤细胞增殖，因此本发明通过使细胞与p49 / STRAP接触来提供抑制癌细胞增殖的方法。

    Method of screening for agents to treat heart failure
    10.
    发明申请
    Method of screening for agents to treat heart failure 有权
    筛查治疗心力衰竭的药物的方法

    公开(公告)号：US20090187998A1

    公开(公告)日：2009-07-23

    申请号：US12313539

    申请日：2008-11-22

    申请人： Jeanne Y. Wei ,  Gohar Azhar ,  Xiaomin Zhang

    发明人： Jeanne Y. Wei ,  Gohar Azhar ,  Xiaomin Zhang

    IPC分类号： A61K49/00 ,  G01N33/53 ,  C12Q1/02 ,  C12Q1/68

    CPC分类号： A61K49/0008 ,  G01N33/5008 ,  G01N33/5088 ,  G01N2333/4703

    摘要： The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.

    摘要翻译： 本发明提供了一种鉴定候选试剂以测试涉及舒张功能障碍的心力衰竭的方法，所述方法包括：测试试剂以确定其是否（a）是否结合血清反应因子（SRF），（b）降低SRF与 血清反应元件（SRE）或（c）降低细胞中的SRF蛋白水平; 其中如果代理人执行（a），（b）和（c）中的一个或多个，则将其识别为候选代理。