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    Method of determining a parameter indicative of the progress of an extracorporeal blood treatment
    1.
    发明授权
    Method of determining a parameter indicative of the progress of an extracorporeal blood treatment 有权
    确定指示体外血液治疗进展的参数的方法

    公开(公告)号：US6110384A

    公开(公告)日：2000-08-29

    申请号：US152071

    申请日：1998-09-11

    申请人： Nicolas Goux ,  Jan Sternby

    发明人： Nicolas Goux ,  Jan Sternby

    IPC分类号： A61M1/14 ,  A61M1/16 ,  B01D61/54

    CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M1/165

    摘要： A method is disclosed for determining a parameter (D, K, Kt/v, Cbin) indicative of the effectiveness of an extracorporeal blood treatment carried out using a membrane exchanger. The method includes the steps of flowing through the exchanger a treatment liquid having a concentration characteristic (Cd) and of varying the value of the characteristic (Cd) upstream of the exchanger for a time at the end of which the characteristic (Cd) is returned to a nominal value. A plurality of values adopted by the characteristic (Cd) downstream of the exchanger in response to the upstream variation is measured and stored in memory. The area (Sout) of a downstream perturbation region is determined, which is bounded by a baseline and a curve representing the variation of the measured values with respect to time. Then, the parameter (D, K, Kt/v, Cbin) indicative of the effectiveness of the treatment is calculated using the area (Sin) beneath the upstream curve and an area beneath an upstream curve.

    摘要翻译： 公开了一种用于确定指示使用膜交换器进行的体外血液处理的有效性的参数（D，K，Kt / v，Cbin）的方法。 该方法包括以下步骤：使具有浓度特性（Cd）的处理液流过交换器上游的特性（Cd）的值，并返回特征（Cd）的时间。 到一个名义价值。 在交换器的下游特性（Cd）响应于上游变化采用的多个值被测量并存储在存储器中。 确定下游扰动区域（Sout），其由基线和表示测量值相对于时间的变化的曲线限定。 然后，使用上游曲线下方的面积（Sin）和上游曲线下方的面积计算表示治疗有效性的参数（D，K，Kt / v，Cbin）。

    Method for the determination of a significant parameter of the progess of an extracorporeal treatment of blood
    3.
    发明授权
    Method for the determination of a significant parameter of the progess of an extracorporeal treatment of blood 失效
    确定血液体外治疗进展的重要参数的方法

    公开(公告)号：US5567320A

    公开(公告)日：1996-10-22

    申请号：US358175

    申请日：1994-12-16

    申请人： Nicolas Goux ,  Bernard Bene

    发明人： Nicolas Goux ,  Bernard Bene

    IPC分类号： A61M1/16 ,  B01D61/32 ,  A61M37/00

    CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617

    摘要： A method for determining a significant parameter (Cb, D, K, Kt/V) of the progress of an extracorporeal blood treatment carried-out using a membrane exchanger, includes the steps of successively circulating three treatment fluids through the exchanger. Each fluid has a characteristic Cd linked to at least one of the significant parameters of the treatment (Cb, D, K, Kt/V). The value of the characteristic in the first fluid upstream of the exchanger is different from the value of the characteristic in the second fluid upstream of the exchanger, the latter being itself different from the value of the characteristic in the third fluid upstream of the exchanger. Two values for each of the three treatment fluids are measured, respectively upstream and downstream of the exchanger, and at least one value of at least one significant parameter of the progress of the treatment (Cb, D, K, Kt/V) is calculated from the measured values.

    摘要翻译： 用于确定使用膜交换器进行的体外血液处理进展的显着参数（Cb，D，K，Kt / V）的方法包括以下步骤：通过交换器连续循环三种处理流体。 每种流体具有与至少一种治疗的重要参数（Cb，D，K，Kt / V）连接的特征性Cd。 在交换器上游的第一流体中的特性值与交换器上游的第二流体中的特性值不同，后者本身不同于交换器上游的第三流体中的特性值。 分别在交换器的上游和下游测量三种处理流体中的每一种的两个值，并且计算处理进展（Cb，D，K，Kt / V）的至少一个有效参数的至少一个值 从测量值。

    Device and method for controlling the balance of fluids in an extracorporeal blood circuit
    5.
    发明授权
    Device and method for controlling the balance of fluids in an extracorporeal blood circuit 失效
    用于控制体外血液回路中流体平衡的装置和方法

    公开(公告)号：US5470483A

    公开(公告)日：1995-11-28

    申请号：US215701

    申请日：1994-03-21

    申请人： Bernard Bene ,  Nicolas Goux

    发明人： Bernard Bene ,  Nicolas Goux

    IPC分类号： A61M1/14 ,  A61M1/34 ,  A61M1/36 ,  B01D61/00 ,  B01D61/18 ,  B01D61/22 ,  B01D61/32

    CPC分类号： A61M1/3441 ,  A61M1/3437 ,  A61M1/3603 ,  A61M1/3413 ,  Y10S210/929

    摘要： A device and method are provided for controlling the balance of fluids during an extracorporeal blood treatment session, according to which treatment, a certain quantity of liquid is withdrawn from the blood which is compensated for by the injection of a substitute liquid into the extracorporeal circuit. A recirculation circuit is provided and pressure is monitored. A pressure deviation within the recirculation circuit reflects a change in the balance between the quantity of liquid withdrawn from the blood and the quantity of liquid injected into the blood, and injection and/or withdrawal rates are altered to obtain a desired balance. The device and method are especially applicable to haemofiltration, haemodiafiltration and plasmapheresis.

    摘要翻译： 提供了一种用于在体外血液治疗期间控制流体平衡的装置和方法，根据该装置和方法，从血液中取出一定量的液体，通过将替代液体注射到体外循环来补偿。 提供再循环回路并监测压力。 再循环回路内的压力偏差反映了从血液中取出的液体的量与注入血液的液体的量之间的平衡变化，并且改变注射和/或撤出速率以获得期望的平衡。 该装置和方法特别适用于血液滤过，血液透析和血浆置换。

    Method for checking the operation of sensors situated in a dialysis liquid circuit
    9.
    发明授权
    Method for checking the operation of sensors situated in a dialysis liquid circuit 失效
    用于检查位于透析液体回路中的传感器的操作的方法

    公开(公告)号：US5399157A

    公开(公告)日：1995-03-21

    申请号：US085932

    申请日：1993-07-06

    申请人： Nicolas Goux ,  Bernard Bene

    发明人： Nicolas Goux ,  Bernard Bene

    IPC分类号： A61M1/16 ,  A61M37/00

    CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  A61M2205/70

    摘要： The invention is a method for checking the operation of at least one sensor situated in a dialysis liquid circuit of an artificial kidney. The method includes causing a reference liquid of known characteristics to circulate in the extracorporeal blood circuit, taking a measurement to check at least one characteristic of the dialysis liquid by means of the sensor, calculating the theoretical value of at least one characteristic of the reference liquid on the basis of the measurement, comparing the calculated theoretical value with the known value of the said characteristic of the reference liquid, concluding that the sensor is working properly after the measurement has been taken when the calculated theoretical value is substantially equal to the known value. A device for the application of this method is also disclosed.

    摘要翻译： 本发明是一种用于检查位于人造肾透析液回路中的至少一个传感器的操作的方法。 所述方法包括使已知特征的参考液体在体外血液回路中循环，进行测量以通过传感器检查透析液体的至少一个特性，计算参考液体的至少一个特性的理论值 基于测量，将计算的理论值与参考液体的所述特性的已知值进行比较，得出结论，当计算的理论值基本上等于已知值时，传感器在已经进行测量之后正常工作 。 还公开了一种用于该方法的应用的装置。