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    Methods and Compositions for Imaging and Biomedical Applications
    4.
    发明申请
    Methods and Compositions for Imaging and Biomedical Applications 审中-公开
    成像和生物医学应用的方法和组合

    公开(公告)号：US20080014149A1

    公开(公告)日：2008-01-17

    申请号：US11578261

    申请日：2005-04-13

    申请人： Niren Murthy ,  Jihua Hao ,  Amy Guinn ,  Stephen Yang ,  Michael Hefferman ,  Bali Pulendran

    发明人： Niren Murthy ,  Jihua Hao ,  Amy Guinn ,  Stephen Yang ,  Michael Hefferman ,  Bali Pulendran

    IPC分类号： A61B5/055

    CPC分类号： A61K49/14 ,  A61K47/60 ,  A61K47/65 ,  A61K49/085 ,  A61K49/126

    摘要： The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable agent. Due to the actions of a specific bioactivity in vivo or in vitro, the detectable construct is altered in some manner so that the detectable agent is detected. The present invention provides diagnostic imaging agents such as for MRI and optical imaging, which are used for sensitive detection of a specific bioactivity within a tissue. The present invention comprises methods and compositions for biocleavable or biodegradable compositions for carrying and releasing active agents for therapeutic or other medical uses. The methods and compositions of the present invention further comprise micelle compositions. The active agents of the present invention may comprise drugs, vaccines, and imaging agents.

    摘要翻译： 本发明涉及用于制备和使用这些组合物的可检测组合物和方法。 可检测组合物包含包含可检测试剂的可检测构建体。 由于在体内或体外具有特异性生物活性的作用，可检测的构建体以某种方式改变，以便检测到可检测的试剂。 本发明提供了用于MRI和光学成像的诊断显像剂，其用于敏感地检测组织内的特异性生物活性。 本发明包括用于携带和释放用于治疗或其它医疗用途的活性剂的可生物可降解或可生物降解的组合物的方法和组合物。 本发明的方法和组合物还包含胶束组合物。 本发明的活性剂可以包括药物，疫苗和成像剂。

    Enhanced transport using membrane disruptive agents
    8.
    发明授权
    Enhanced transport using membrane disruptive agents 有权
    增强运输使用膜破坏剂

    公开(公告)号：US07737108B1

    公开(公告)日：2010-06-15

    申请号：US09755701

    申请日：2001-01-05

    申请人： Allan S. Hoffman ,  Patrick S. Stayton ,  Niren Murthy

    发明人： Allan S. Hoffman ,  Patrick S. Stayton ,  Niren Murthy

    IPC分类号： A61K38/00 ,  A61K31/70 ,  A61K47/00 ,  A61K9/50 ,  C08F20/58

    CPC分类号： A61K47/6883 ,  A61K47/56 ,  A61K47/62

    摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

    摘要翻译： 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是对于细胞膜（在生理pH下）相对无活性的化合物，但是如果环境被酸化至低于约5℃，则可以变得对细胞膜有活性。 pH 6.8），直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 还可以与破坏剂一起使用增强交付如超声，离子层析和/或电穿孔的处理。

    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS
    9.
    发明申请
    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS 有权
    使用薄膜破坏剂加强运输

    公开(公告)号：US20080199957A1

    公开(公告)日：2008-08-21

    申请号：US12105983

    申请日：2008-04-18

    申请人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    发明人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    IPC分类号： C12N5/06

    CPC分类号： A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

    摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.

    摘要翻译： 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强交付如超声波，离子电渗疗法和/或电泳的治疗也可与破坏剂一起使用。