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公开(公告)号：US06716613B1
公开(公告)日：2004-04-06
申请号：US10009332
申请日：2001-12-10
申请人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
发明人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.
摘要翻译： 本发明提供了具有引起关节疾病的聚集蛋白聚糖酶活性的新型金属蛋白酶，编码该金属蛋白酶的基因，上述金属蛋白酶的启动子，使用上述金属蛋白酶进行药物筛选的方法和抑制降解的药物组合物 蛋白多糖，其包含作为活性成分的能够抑制上述金属蛋白酶的聚集蛋白聚糖酶活性的物质。
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公开(公告)号：US07193073B2
公开(公告)日：2007-03-20
申请号：US11285804
申请日：2005-11-23
申请人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe
发明人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe
CPC分类号： C12N9/6489 , A61K38/00 , C12N9/6421 , G01N2500/04
摘要： A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed.The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).
摘要翻译： 新的多肽，编码该多肽的多核苷酸，包含该多核苷酸的表达载体，用表达载体转染的细胞，与上述多肽结合的抗体，用于获得治疗关节疾病的药剂的方便的筛选方法，以及 公开了制备用于治疗关节疾病的药物组合物。 该多肽是一种新型的聚集蛋白聚糖酶，其是关节疾病（特别是OA病）。
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公开(公告)号：US20060014931A1
公开(公告)日：2006-01-19
申请号：US10509565
申请日：2003-06-19
申请人： Masayoshi Takeda , Kunitake Abe , Noboru Yamaji
发明人： Masayoshi Takeda , Kunitake Abe , Noboru Yamaji
CPC分类号： C12N9/6421 , A61K38/00
摘要： Disclosing a promoter of the protease MDTS9, which is induced by TGF-β, which is involved in the metabolism of extracellular matrix, and in which the expression of the gene thereof is elevated in renal failure model animals, which promoter is useful as a tool for screening an agent for treating and/or preventing chronic renal failure, as well as a method for screening an agent for treating and/or preventing chronic renal failure by selecting an inhibitor of the promoter.
摘要翻译： 公开了参与细胞外基质代谢的TGF-β诱导的蛋白酶MDTS9的启动子，其中在肾衰竭模型动物中其基因的表达升高，该启动子可用作工具 用于筛选用于治疗和/或预防慢性肾衰竭的药剂，以及通过选择启动子的抑制剂筛选用于治疗和/或预防慢性肾衰竭的药剂的方法。
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公开(公告)号：US07157567B2
公开(公告)日：2007-01-02
申请号：US10491277
申请日：2003-02-19
申请人： Kunitake Abe , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
发明人： Kunitake Abe , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
CPC分类号： G01N33/74 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/042 , G03G15/0882
摘要： A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.
摘要翻译： 公开了用于II型糖尿病治疗剂的筛选工具和筛选方法，特别是用于缓解胰岛素抵抗的药剂。 还公开了可用于筛选工具和筛选方法的新型多肽，多核苷酸，载体，启动子和转化体。
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公开(公告)号：US07374923B2
公开(公告)日：2008-05-20
申请号：US11593512
申请日：2006-11-07
申请人： Kunitake Abe , Masayoshi Takeda , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
发明人： Kunitake Abe , Masayoshi Takeda , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
CPC分类号： G01N33/74 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/042 , G03G15/0882
摘要： A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.
摘要翻译： 公开了用于II型糖尿病治疗剂的筛选工具和筛选方法，特别是用于缓解胰岛素抵抗的药剂。 还公开了可用于筛选工具和筛选方法的新型多肽，多核苷酸，载体，启动子和转化体。
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公开(公告)号：US20080102459A1
公开(公告)日：2008-05-01
申请号：US11792191
申请日：2005-12-01
申请人： Kunio Yasunaga , Noboru Yamaji , Kunitake Abe , Yuichi Oike
发明人： Kunio Yasunaga , Noboru Yamaji , Kunitake Abe , Yuichi Oike
IPC分类号： C12Q1/68
CPC分类号： G01N33/6872 , G01N33/6893 , G01N2333/515 , G01N2500/00 , G01N2800/044
摘要： The present invention relates to a method of screening for an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent, comprising the step of analyzing whether or not a substance to be tested promotes an expression and/or a function of an angiopoietin-related growth factor. The present invention relates to a method of screening for an agent for promoting an expression and/or a function of an angiopoietin-related growth factor.
摘要翻译： 本发明涉及筛选抗肥胖剂，抗糖尿病药和/或降血脂药的方法，包括分析待测试物质是否促进血管生成素-1的表达和/或功能的步骤， 相关生长因子。 本发明涉及筛选促进血管生成素相关生长因子的表达和/或功能的药剂的方法。
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公开(公告)号：US20070077591A1
公开(公告)日：2007-04-05
申请号：US11593512
申请日：2006-11-07
申请人： Kunitake Abe , Masayoshi Takeda , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
发明人： Kunitake Abe , Masayoshi Takeda , Noboru Yamaji , Miyuki Katou , Tetsuo Matsui
CPC分类号： G01N33/74 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/042 , G03G15/0882
摘要： A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.
摘要翻译： 公开了用于II型糖尿病治疗剂的筛选工具和筛选方法，特别是用于缓解胰岛素抵抗的药剂。 还公开了可用于筛选工具和筛选方法的新型多肽，多核苷酸，载体，启动子和转化体。
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8.发明授权Genes coding for a protein having human MACIF activity, expression vectors containing said genes, transformant cells and proteins having human macif activity 失效编码具有人MACIF活性的蛋白质的基因，含有所述基因的表达载体，转化体细胞和具有人类macif活性的蛋白质
公开(公告)号：US5795736A
公开(公告)日：1998-08-18
申请号：US514183
申请日：1995-08-11
申请人： Motowo Tomita , Yuji Sugita , Toshiyuki Takemoto , Kiyoshi Furuichi , Makoto Takayama , Ko Yasukawa , Katsuhisa Ito , Noboru Yamaji , Shinya Yano
发明人： Motowo Tomita , Yuji Sugita , Toshiyuki Takemoto , Kiyoshi Furuichi , Makoto Takayama , Ko Yasukawa , Katsuhisa Ito , Noboru Yamaji , Shinya Yano
IPC分类号： A61K38/00 , C07K4/12 , C07K14/705 , C12N15/12
CPC分类号： C07K14/70596 , A61K38/00 , Y10S530/808
摘要： Genes coding for a protein having human MACIF activity, expression vectors containing the genes, transformed cells with the vectors and proteins having human MACIF activity.
摘要翻译： 编码具有人MACIF活性的蛋白质的基因，含有该基因的表达载体，具有载体的转化细胞和具有人MACIF活性的蛋白质。
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公开(公告)号：US06291206B1
公开(公告)日：2001-09-18
申请号：US08123934
申请日：1993-09-17
IPC分类号： C12P2106
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。
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公开(公告)号：US07091007B2
公开(公告)日：2006-08-15
申请号：US10600645
申请日：2003-06-23
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。
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