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1.发明授权Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them 有权超疏水分层结构，形成方法和结合它们的医疗器械公开(公告)号：US08926881B2
公开(公告)日：2015-01-06
申请号：US13441496
申请日：2012-04-06
申请人： Audrey Yoke Yee Ho , Isabel Rodriguez , Hong Yee Low , Emma Kim Luong-Van , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Chee Tiong Lim
发明人： Audrey Yoke Yee Ho , Isabel Rodriguez , Hong Yee Low , Emma Kim Luong-Van , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Chee Tiong Lim
IPC分类号： B32B3/30
CPC分类号： A61L31/14 , A61L27/50 , A61L27/56 , A61L31/146 , A61L2400/18 , B82Y30/00 , B82Y40/00 , Y10T428/24355
摘要： Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 μm to about 400 μm, heights in the range from about 2.5 μm and about 500 μm, and said pillars have diameters in the range from about 20 nm to about 5 μm and aspect ratios of from about 2 to about 50, and methods of making and using them.
摘要翻译： 合成聚合物基材，其包含在所述圆顶上的多个圆顶和多个柱的分层表面结构，其中所述基材是合成聚合物膜，所述圆顶的直径在约5μm至约400μm的范围内，高度在约2.5 μm和约500μm，并且所述柱具有在约20nm至约5μm范围内的直径和约2至约50的纵横比，以及制造和使用它们的方法。
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公开(公告)号：US20130267880A1
公开(公告)日：2013-10-10
申请号：US13441539
申请日：2012-04-06
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim
CPC分类号： B29C59/14 , A61F13/00017 , A61F13/00063 , A61F2013/00472 , B29K2023/12
摘要： A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.
摘要翻译： 一种凝血基质和装置，其具有从聚丙烯膜的表面延伸的多个氧等离子体处理的聚丙烯支柱。
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公开(公告)号：US09492952B2
公开(公告)日：2016-11-15
申请号：US13435544
申请日：2012-03-30
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
CPC分类号： B29C33/52 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L27/18 , A61L31/06 , Y10T428/24355 , C08L67/04
摘要： A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.
摘要翻译： 一种聚二恶烷酮薄膜，其至少在其一面上包括基本上圆柱形的聚二恶烷酮柱，所述柱具有约0.2μm至约3μm的直径，以及距膜的约2μm至约20μm的高度，用于吸附蛋白质的方法 使用包含该膜的胶片和医疗装置。
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公开(公告)号：US08969648B2
公开(公告)日：2015-03-03
申请号：US13441539
申请日：2012-04-06
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim
IPC分类号： A61F13/00
CPC分类号： B29C59/14 , A61F13/00017 , A61F13/00063 , A61F2013/00472 , B29K2023/12
摘要： A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.
摘要翻译： 一种凝血基质和装置，其具有从聚丙烯膜的表面延伸的多个氧等离子体处理的聚丙烯支柱。
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公开(公告)号：US20120251611A1
公开(公告)日：2012-10-04
申请号：US13435544
申请日：2012-03-30
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
CPC分类号： B29C33/52 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L27/18 , A61L31/06 , Y10T428/24355 , C08L67/04
摘要： A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.
摘要翻译： 一种聚二恶烷酮薄膜，其至少在其一面上包括基本上圆柱形的聚二恶烷酮柱，所述柱具有约0.2μm至约3μm的直径，以及距膜的约2μm至约20μm的高度，用于吸附蛋白质的方法 使用包含该膜的胶片和医疗装置。
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公开(公告)号：US20130288225A1
公开(公告)日：2013-10-31
申请号：US13458825
申请日：2012-04-27
申请人： Noha Elmouelhi , Sriram Natarajan , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim , Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho
发明人： Noha Elmouelhi , Sriram Natarajan , Kevin Cooper , Murty Vyakarnam , Chee Tiong Lim , Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Audrey Yoke Yee Ho
IPC分类号： C12N5/078
CPC分类号： G01N33/491
摘要： A method of separating blood by providing a horizontal substrate having a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film, depositing a whole blood sample on an upper surface of the substrate, collecting red blood cells on the upper surface of the pillars and permitting remaining components of said whole blood sample to flow downward and through the pillars.
摘要翻译： 提供一种通过提供具有从聚丙烯薄膜表面延伸的多个氧等离子体处理的聚丙烯支柱的水平基底分离血液的方法，将全血样品沉积在基底的上表面上，在上表面上收集红细胞 并且允许所述全血样品的剩余组分向下流动并穿过支柱。
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7.发明申请SUPER-HYDROPHOBIC HIERARCHICAL STRUCTURES, METHOD OF FORMING THEM AND MEDICAL DEVICES INCORPORATING THEM 有权超级疏水分层结构，其形成方法和与其配套的医疗器械公开(公告)号：US20130266761A1
公开(公告)日：2013-10-10
申请号：US13441496
申请日：2012-04-06
申请人： Audrey Yoke Yee Ho , Isabel Rodriguez , Hong Yee Low , Emma Kim Luong-Van , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Chee Tiong Lim
发明人： Audrey Yoke Yee Ho , Isabel Rodriguez , Hong Yee Low , Emma Kim Luong-Van , Sriram Natarajan , Noha Elmouelhi , Kevin Cooper , Chee Tiong Lim
CPC分类号： A61L31/14 , A61L27/50 , A61L27/56 , A61L31/146 , A61L2400/18 , B82Y30/00 , B82Y40/00 , Y10T428/24355
摘要： Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 μm to about 400 μm, heights in the range from about 2.5 μm and about 500 μm, and said pillars have diameters in the range from about 20 nm to about 5 μm and aspect ratios of from about 2 to about 50, and methods of making and using them.
摘要翻译： 合成聚合物基材，其包括多个圆顶的分层表面结构和在所述圆顶上的多个柱，其中所述基材是合成聚合物膜，所述圆顶的直径在约5μm至约400μm的范围内，高度在约2.5 并且所述支柱具有在约20nm至约5μm范围内的直径和约2至约50的纵横比，以及制造和使用它们的方法。
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8.发明申请POLYMERIC STRUCTURES FOR ADSORBING BIOLOGICAL MATERIAL AND THEIR METHOD OF PREPARATION 审中-公开用于吸收生物材料的聚合物结构及其制备方法公开(公告)号：US20120302427A1
公开(公告)日：2012-11-29
申请号：US13340405
申请日：2011-12-29
申请人： Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Hong Yee Low , Isabel Rodriguez , Emma Kim Luong-Van
发明人： Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Hong Yee Low , Isabel Rodriguez , Emma Kim Luong-Van
CPC分类号： B01J20/28042 , B01J20/265 , B01J20/268 , B01J20/3007 , B01J20/3057
摘要： A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 μm and height greater than 1 μm.
摘要翻译： 通过将聚合物底物形成具有可以控制其生物吸附性能的高表面积形貌的结构来制备生物吸附剂，例如蛋白质吸附剂材料。 这些优化的高表面积形貌的这些结构的生物吸附通过温和处理表面，例如通过氧等离子体而没有基本上改变形貌而增加。 结构可以具有定制的几何特征，包括直径为100nm-50μm且高度大于1μm的微结构（例如柱）。
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