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公开(公告)号：US20130184335A1
公开(公告)日：2013-07-18
申请号：US13809880
申请日：2011-06-28
Applicant: Norimasa Miura
Inventor： Norimasa Miura
IPC: C07H21/02
CPC classification number: C12N15/113 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N5/0696 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2501/65 , A61K2300/00
Abstract: A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including one or more single-stranded or double-stranded polynucleotides selected from the group consisting of: a) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:1 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 1, b) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:2 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 2, c) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:3 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 3, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided.
Abstract translation: 提供了诱导多能干细胞的新型化合物。 提供了一种新的抗恶性肿瘤物质。 多能干细胞诱导剂，包括一个或多个选自以下的单链或双链多核苷酸：a）含有SEQ ID NO：1的序列的单链或双链多核苷酸或序列 包括在SEQ ID No：1中删除，取代或添加1至3个碱基，b）含有SEQ ID NO：2的序列的单链或双链多核苷酸或包括缺失，取代或添加的序列 SEQ ID No：2中的1至3个碱基，c）包含SEQ ID NO：3的序列的单链或双链多核苷酸或包含SEQ ID NO：3中1-3个碱基的缺失，取代或添加的序列 3，其中多能干细胞诱导剂诱导成为多能干细胞的细胞。
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公开(公告)号：US09476041B2
公开(公告)日：2016-10-25
申请号：US13809880
申请日：2011-06-28
Applicant: Norimasa Miura
Inventor： Norimasa Miura
IPC: C07H21/02 , C07H21/04 , A61K48/00 , C12N15/11 , C12N15/113 , A61K31/7105 , A61K31/713 , C12N5/074
CPC classification number: C12N15/113 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N5/0696 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2501/65 , A61K2300/00
Abstract: A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including one or more single-stranded or double-stranded polynucleotides selected from the group consisting of: a) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:1 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 1, b) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:2 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 2, c) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:3 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 3, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided.
Abstract translation: 提供了诱导多能干细胞的新型化合物。 提供了一种新的抗恶性肿瘤物质。 多能干细胞诱导剂，包括一个或多个选自以下的单链或双链多核苷酸：a）含有SEQ ID NO：1的序列的单链或双链多核苷酸或序列 包括在SEQ ID No：1中删除，取代或添加1至3个碱基，b）含有SEQ ID NO：2的序列的单链或双链多核苷酸或包括缺失，取代或添加的序列 SEQ ID No：2中的1至3个碱基，c）包含SEQ ID NO：3的序列的单链或双链多核苷酸或包含SEQ ID NO：3中1-3个碱基的缺失，取代或添加的序列 3，其中多能干细胞诱导剂诱导成为多能干细胞的细胞。
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公开(公告)号：US07985852B2
公开(公告)日：2011-07-26
申请号：US11911364
申请日：2006-03-28
Applicant: Norimasa Miura
Inventor： Norimasa Miura
CPC classification number: A61K48/00 , C07K14/4702
Abstract: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated.
Abstract translation: 公开了能够调节哺乳动物细胞中端粒酶逆转录酶基因表达的新物质。 能够调节hTERT表达的基因，其包含SEQ ID No：1或2所示的核苷酸序列。端粒酶逆转录酶基因的表达可以通过抑制基因的表达来抑制。 通过利用这种机制，可以调节端粒酶逆转录酶基因的表达。
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公开(公告)号：US20100248356A1
公开(公告)日：2010-09-30
申请号：US12751160
申请日：2010-03-31
Applicant: Norimasa Miura
Inventor： Norimasa Miura
CPC classification number: A61K48/00 , C07K14/4702
Abstract: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated.
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公开(公告)号：US10265347B2
公开(公告)日：2019-04-23
申请号：US14914788
申请日：2014-08-28
Applicant: Norimasa Miura
Inventor： Norimasa Miura
IPC: A61K35/545 , C12N5/074 , C12N15/113 , A61K35/00
Abstract: Disclosed is a novel process for producing a Muse cell-like cell or a novel method for extending the replicative life span of a cell population. Provided is a process for producing a Muse cell-like cell, comprising the step of inhibiting the expression or function of ELAVL2, TEAD1, or GATAD2B. At this time, siRNA or shRNA may be used to inhibit the expression or function of ELAVL2, TEAD1, or GATAD2B.
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Patent Agency Ranking
公开(公告)号：US20130190389A1
公开(公告)日：2013-07-25
申请号：US13809882
申请日：2011-06-28
Applicant: Norimasa Miura
Inventor： Norimasa Miura
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N5/0696 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2501/65 , A61K2300/00
Abstract: A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including a single-stranded or double-stranded polynucleotide containing the base sequence shown in SEQ ID NO:41 or a base sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 41, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided.
Abstract translation: 提供了诱导多能干细胞的新型化合物。 提供了一种新的抗恶性肿瘤物质。 多能干细胞诱导剂，包括含有SEQ ID NO：41所示碱基序列的单链或双链多核苷酸，或包含SEQ ID No：41所示碱基序列的1〜3个碱基的缺失，取代或添加的碱基序列。 41，其中多能干细胞诱导剂诱导成为多能干细胞的细胞。
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公开(公告)号：US08148513B2
公开(公告)日：2012-04-03
申请号：US12751160
申请日：2010-03-31
Applicant: Norimasa Miura
Inventor： Norimasa Miura
CPC classification number: A61K48/00 , C07K14/4702
Abstract: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated.
Abstract translation: 公开了能够调节哺乳动物细胞中端粒酶逆转录酶基因表达的新物质。 能够调节hTERT表达的基因，其包含SEQ ID No：1或2所示的核苷酸序列。端粒酶逆转录酶基因的表达可以通过抑制基因的表达来抑制。 通过利用这种机制，可以调节端粒酶逆转录酶基因的表达。
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公开(公告)号：US20100184216A1
公开(公告)日：2010-07-22
申请号：US12751226
申请日：2010-03-31
Applicant: Norimasa Miura
Inventor： Norimasa Miura
CPC classification number: A61K48/00 , C07K14/4702
Abstract: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated.
Abstract translation: 公开了能够调节哺乳动物细胞中端粒酶逆转录酶基因表达的新物质。 能够调节hTERT表达的基因，其包含SEQ ID No：1或2所示的核苷酸序列。端粒酶逆转录酶基因的表达可以通过抑制基因的表达来抑制。 通过利用这种机制，可以调节端粒酶逆转录酶基因的表达。
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公开(公告)号：US4962840A
公开(公告)日：1990-10-16
申请号：US380765
申请日：1989-07-17
Applicant: Norimasa Miura , Yoshihisa Sato
Inventor： Norimasa Miura , Yoshihisa Sato
CPC classification number: A24C5/35
Abstract: A control system for a cigarette making and pack aging system including a cigarette making machine, a cigarette packaging machine with a variable operation speed, and a reservoir mechanism provided between the cigarette making machine and the cigarette packaging machine, a current reserve amount calculating unit for calculating a current reserve amount in the reservoir mechanism, an intermediate reserve amount calculating unit for calculating an intermediate reserve amount, a desired value setting unit for setting a maximum reserve amount and a minimum reserve amount of the reservoir mechanism on the basis of the intermediate reserve amount, a comparison unit for comparing the current reserve amount with the maximum reserve amount and the minimum reserve amount, and a speed control unit for controlling the speed of the packaging machine on the basis of a comparison result by the comparison unit. The intermediate reserve amount is updated periodically with a predetermined period of time is such a way that a new value of the intermediate reserve amount for the following period of time is based on the average down time of the cigarette making machine and that of the cigarette packaging machine over the immediately preceding time interval, thus the minimum and maximum reserve amount at which the speed of the packaging machine is switched are automatically updated accordingly.
Abstract translation: 一种用于卷烟制造和包装老化系统的控制系统，包括卷烟机，具有可变操作速度的卷烟包装机，以及设置在卷烟机和香烟包装机之间的储存机构，一个电流储备量计算单元， 计算储层机构中的当期准备金额，用于计算中间储备金的中间储备金计算单元，用于基于中间储备设定储层机构的最大储备量和最小储量的期望值设定单元 数量，比较单元，用于比较当前储备金量与最大储备金额和最小储备金额;以及速度控制单元，用于根据比较单元的比较结果来控制包装机的速度。 中间储备金在预定时间段周期性地更新，使得下一个时间段的中间储备金的新值基于卷烟机的平均停机时间和卷烟包装的平均停机时间 机器在紧接在前的时间间隔之间，因此自动更新包装机切换速度的最小和最大储备量。
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公开(公告)号：US20140013590A1
公开(公告)日：2014-01-16
申请号：US14007338
申请日：2012-03-16
Applicant: Katsunari Norita , Norimasa Miura , Setsuko Koura
Inventor： Katsunari Norita , Norimasa Miura , Setsuko Koura
IPC: H01M2/02
CPC classification number: H01M2/02 , B21D22/22 , H01M2/0277 , H01M2/0285 , H01M2/0287 , Y10T29/49115
Abstract: In method for manufacturing an external cladding for a laminate battery according to the present invention, austenitic stainless steel foil having a thermoplastic resin layer on one of a front surface and a rear surface and a lubricating film on the other surface is used as a material, the stainless steel foil is disposed such that the surface provided with the thermoplastic resin layer opposes a punch, and drawing is implemented on the stainless steel foil without using lubricating oil in a condition where an annular region of the stainless steel foil, which is contacted by a shoulder portion of the punch, is set at a temperature of 20° C. or lower, and an exterior region on an exterior of the annular region is set at a temperature between 40° C. and 100° C.
Abstract translation: 在本发明的叠层电池用外包层的制造方法中，使用在前表面和后表面之一上具有热塑性树脂层的另一表面上的润滑膜的奥氏体不锈钢箔作为材料， 不锈钢箔被设置成使得设置有热塑性树脂层的表面与冲头相对，并且在不使用润滑油的情况下在不锈钢箔上实施拉伸，在不锈钢箔的环形区域被接触的条件下 冲头的肩部设置在20℃或更低的温度，并且环形区域的外部的外部区域设定在40℃和100℃之间的温度。
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