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公开(公告)号：US20230144853A1
公开(公告)日：2023-05-11
申请号：US18058320
申请日：2022-11-23
申请人： Novan, Inc.
发明人： Nathan Stasko , Ryan Doxey
CPC分类号： A61K8/64 , A61K8/345 , A61K8/368 , A61K8/8158 , A61K8/9794 , A61Q19/00
摘要： The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a solvent, a penetration enhancing agent, a skin brightening agent, a skin renewing agent, a thickening agent, an anti-irritant, a chelating agent, an active pharmaceutical ingredient (API), optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.
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公开(公告)号：US11583608B2
公开(公告)日：2023-02-21
申请号：US15887649
申请日：2018-02-02
申请人： Novan, Inc.
发明人： Nathan Stasko , Susanne Bauman , Pranav R. Joshi
摘要： Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.
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公开(公告)号：US11534382B2
公开(公告)日：2022-12-27
申请号：US16623831
申请日：2018-06-19
申请人： Novan, Inc.
发明人： Nathan Stasko , Ryan Doxey
摘要： The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a solvent, a penetration enhancing agent, a skin brightening agent, a skin renewing agent, a thickening agent, an anti-irritant, a chelating agent, an active pharmaceutical ingredient (API), optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.
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公开(公告)号：US10849864B2
公开(公告)日：2020-12-01
申请号：US15747981
申请日：2016-07-25
申请人： Novan, Inc.
发明人： Kimberly McHale , Nathan Stasko
IPC分类号： A61K31/137 , A61K31/655 , A61K31/695 , A61P31/10 , A61K41/00 , C01B21/24 , A61K45/06 , A61K31/795 , A61K31/80 , A61K33/00
摘要： Provided are combinations comprising terbinafine or a pharmaceutically acceptable salt thereof and a NO source. The combination may be a synergistic combination. Also provided are methods of treating and/or preventing a fungal infection in a subject comprising administering terbinafine or a pharmaceutically acceptable salt thereof to the subject; and administering a NO source to the subject, thereby treating and/or preventing the fungal infection in the subject. The dose of terbinafine or a pharmaceutically acceptable salt thereof and the dose of the NO source administered to the subject may achieve a synergistic effect.
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公开(公告)号：US20200230048A1
公开(公告)日：2020-07-23
申请号：US16840657
申请日：2020-04-06
申请人： Novan, Inc.
发明人： Kimberly McHale , Ryan Doxey , Nathan Stasko
IPC分类号： A61K9/00 , A61K31/675 , A61K9/06 , A61K47/24 , A61K47/44 , A61K47/26 , A61K47/02 , A61K47/14 , A61K47/10 , A61K33/00
摘要： The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
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6.发明申请公开(公告)号：US20200055815A1
公开(公告)日：2020-02-20
申请号：US16555673
申请日：2019-08-29
发明人： Mark Schoenfisch , Yuan Lu , Nathan Stasko , Jian Bao
IPC分类号： C07C281/20 , C07C247/10 , A61K31/655 , C07C291/02
摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
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7.发明申请公开(公告)号：US20190135738A1
公开(公告)日：2019-05-09
申请号：US16239069
申请日：2019-01-03
发明人： Mark Schoenfisch , Yuan Lu , Nathan Stasko , Jian Bao
IPC分类号： C07C281/20 , C07C247/10 , A61K31/655 , C07C291/02
CPC分类号： C07C281/20 , A61K31/655 , C07C247/10 , C07C291/02 , Y10T428/2982
摘要： Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
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公开(公告)号：US20170312307A1
公开(公告)日：2017-11-02
申请号：US15652824
申请日：2017-07-18
申请人： Novan, Inc.
发明人： Nathan Stasko , Susanne Bauman , Pranav R. Joshi
CPC分类号： A61K31/80 , A61K9/0014 , A61K9/06 , A61K31/655 , A61K33/00 , A61K47/24 , A61K47/59 , A61K47/6903 , A61K2300/00
摘要： Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
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公开(公告)号：US20170216197A1
公开(公告)日：2017-08-03
申请号：US15324332
申请日：2015-07-10
申请人： Novan, Inc.
发明人： Kimberly McHale , Ryan Doxey , Nathan Stasko
CPC分类号： A61K9/0014 , A61K9/06 , A61K33/00 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/38
摘要： The present invention relates generally to topical antiviral compositions and methods of using the same.
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公开(公告)号：US20160038390A1
公开(公告)日：2016-02-11
申请号：US14887648
申请日：2015-10-20
申请人： Novan, Inc.
发明人： Ryan Doxey , Nathan Stasko
CPC分类号： A61K31/695 , A61K8/34 , A61K8/345 , A61K8/368 , A61K8/40 , A61K8/585 , A61K8/731 , A61K8/891 , A61K9/0014 , A61K9/143 , A61K47/10 , A61K47/20 , A61K47/34 , A61K47/38 , A61K2800/22 , A61K2800/31 , A61K2800/56 , A61K2800/592 , A61Q19/00
摘要： Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
摘要翻译： 本文提供的是包含至少一种增粘剂，至少一种有机溶剂和至少一种湿润剂的无水组合物。 此类组合物还可以包括至少一种活性药物成分（API）和/或至少一种防水剂。 还提供了相关的组合物，方法和试剂盒。
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