公开(公告)号：US10962803B2

公开(公告)日：2021-03-30

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02B1/04 ,  G02C7/04 ,  C09D143/00 ,  C08F230/00 ,  C08J7/04

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US10968319B2

公开(公告)日：2021-04-06

申请号：US16281400

申请日：2019-02-21

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Maria F. Gubitosi Raspino ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Augustine Twum Kumi ,  Zach Munoz ,  Weihong Lang

IPC: G02B1/04 ,  C08G77/442 ,  C08J3/24 ,  B29D11/00 ,  B29K83/00

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

公开(公告)号：US20190263971A1

公开(公告)日：2019-08-29

申请号：US16281400

申请日：2019-02-21

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Maria F. Gubitosi Raspino ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Augustine Twum Kumi ,  Zach Munoz ,  Weihong Lang

IPC: C08G77/442 ,  G02B1/04 ,  C08J3/24 ,  B29D11/00

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

公开(公告)号：US20190235277A1

公开(公告)日：2019-08-01

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02C7/04 ,  C09D143/00 ,  C08J7/04 ,  C08F230/00

CPC classification number: G02C7/049 ,  C08F230/00 ,  C08J7/047 ,  C08J2329/14 ,  C08J2443/00 ,  C09D143/00 ,  G02B1/043

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US20180356562A1

公开(公告)日：2018-12-13

申请号：US16000930

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00134 ,  C08F230/08 ,  C08L83/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20180355112A1

公开(公告)日：2018-12-13

申请号：US16000933

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08G77/12 ,  C08L83/10 ,  G02B1/04

CPC classification number: C08G77/442 ,  B29D11/00134 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G2210/00 ,  C08L83/10 ,  C08L2201/10 ,  G02B1/043 ,  G02B2207/109 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.