公开(公告)号：US20180356562A1

公开(公告)日：2018-12-13

申请号：US16000930

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00134 ,  C08F230/08 ,  C08L83/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20180355112A1

公开(公告)日：2018-12-13

申请号：US16000933

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08G77/12 ,  C08L83/10 ,  G02B1/04

CPC classification number: C08G77/442 ,  B29D11/00134 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G2210/00 ,  C08L83/10 ,  C08L2201/10 ,  G02B1/043 ,  G02B2207/109 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US09846263B2

公开(公告)日：2017-12-19

申请号：US14539280

申请日：2014-11-12

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Rahul Panicker

IPC: G02B1/10 ,  C09D11/326 ,  C09D17/00 ,  B29D11/00

CPC classification number: G02B1/10 ,  B29D11/00894 ,  C09D11/101 ,  C09D11/322 ,  C09D11/326 ,  C09D17/007 ,  G02C7/00 ,  G02C7/021 ,  G02C7/046

Abstract: The present invention provides a metal oxide dispersion comprises a metal oxide, a millbase and a dispersant. The dispersant in the metal oxide is selected from a group consisting of a phosphoric acid polyester copolymer, a trimethoxysilane compound, a triethoxysilanes compound, dimethylamino ethyl methacrylate (DMAEMA) and a combination thereof, and the dispersion is substantially free of water. The metal oxide dispersion of the invention is useful for manufacturing an inkjet ink to provide a high-quality color image on a contact lens or a mold so as to produce a colored contact lens.

公开(公告)号：US10962803B2

公开(公告)日：2021-03-30

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02B1/04 ,  G02C7/04 ,  C09D143/00 ,  C08F230/00 ,  C08J7/04

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US20150144850A1

公开(公告)日：2015-05-28

申请号：US14539280

申请日：2014-11-12

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Rahul Panicker

IPC: G02B1/10

CPC classification number: G02B1/10 ,  B29D11/00894 ,  C09D11/101 ,  C09D11/322 ,  C09D11/326 ,  C09D17/007 ,  G02C7/00 ,  G02C7/021 ,  G02C7/046

Abstract: The present invention provides a metal oxide dispersion comprises a metal oxide, a millbase and a dispersant. The dispersant in the metal oxide is selected from a group consisting of a phosphoric acid polyester copolymer, a trimethoxysilane compound, a triethoxysilanes compound, dimethylamino ethyl methacrylate (DMAEMA) and a combination thereof, and the dispersion is substantially free of water. The metal oxide dispersion of the invention is useful for manufacturing an inkjet ink to provide a high-quality color image on a contact lens or a mold so as to produce a colored contact lens.

Abstract translation: 本发明提供一种金属氧化物分散体，其包含金属氧化物，碾磨剂和分散剂。 金属氧化物中的分散剂选自磷酸聚酯共聚物，三甲氧基硅烷化合物，三乙氧基硅烷化合物，二甲基氨基乙基甲基丙烯酸酯（DMAEMA）及其组合，分散体基本上不含水。 本发明的金属氧化物分散体可用于制造喷墨油墨，以在隐形眼镜或模具上提供高质量的彩色图像，以产生有色的隐形眼镜。

公开(公告)号：US10968319B2

公开(公告)日：2021-04-06

申请号：US16281400

申请日：2019-02-21

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Maria F. Gubitosi Raspino ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Augustine Twum Kumi ,  Zach Munoz ,  Weihong Lang

IPC: G02B1/04 ,  C08G77/442 ,  C08J3/24 ,  B29D11/00 ,  B29K83/00

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

公开(公告)号：US10364365B2

公开(公告)日：2019-07-30

申请号：US15348346

申请日：2016-11-10

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Ellen A. Day ,  Yongxing Qiu ,  Ritu Shrestha

IPC: C09D11/107 ,  B29D11/00 ,  C09D11/03 ,  C09D11/10 ,  C09D11/101 ,  G02C7/04 ,  C09D11/033 ,  C09D11/037

Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least a pigment, a polymeric dispersant, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromere. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the ink is characterized by having an longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except of no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.

公开(公告)号：US20170183520A1

公开(公告)日：2017-06-29

申请号：US15348346

申请日：2016-11-10

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Ellen A. Day ,  Yongxing Qiu ,  Ritu Shrestha

IPC: C09D11/107 ,  C09D11/033 ,  G02C7/04 ,  C09D11/037

CPC classification number: C09D11/107 ,  B29D11/00038 ,  B29D11/00923 ,  C09D11/03 ,  C09D11/033 ,  C09D11/037 ,  C09D11/10 ,  C09D11/101 ,  G02C7/046 ,  G02C7/049

Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least a pigment, a polymeric dispersant, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromere. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the ink is characterized by having an longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except of no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.

公开(公告)号：US20190263971A1

公开(公告)日：2019-08-29

申请号：US16281400

申请日：2019-02-21

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Maria F. Gubitosi Raspino ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Augustine Twum Kumi ,  Zach Munoz ,  Weihong Lang

IPC: C08G77/442 ,  G02B1/04 ,  C08J3/24 ,  B29D11/00

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

公开(公告)号：US20190235277A1

公开(公告)日：2019-08-01

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02C7/04 ,  C09D143/00 ,  C08J7/04 ,  C08F230/00

CPC classification number: G02C7/049 ,  C08F230/00 ,  C08J7/047 ,  C08J2329/14 ,  C08J2443/00 ,  C09D143/00 ,  G02B1/043

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.