公开(公告)号：US10806566B2

公开(公告)日：2020-10-20

申请号：US16005856

申请日：2018-06-12

Applicant: NOVARTIS AG

Inventor： Xuwei Jiang ,  Thomas A. Callaghan ,  Ahmad R. Hadba

IPC: A61F2/16 ,  G02B1/04 ,  A61L27/16 ,  C08F220/28 ,  C08L33/08 ,  C08L33/24 ,  C08L33/12

Abstract: The present invention provides novel intraocular lens compositions comprising a hydroxyl functional acrylic monomer and have a high Abbe number, minimal glistenings, and suitable mechanical properties for small incision delivery.

公开(公告)号：US20160170092A1

公开(公告)日：2016-06-16

申请号：US14967780

申请日：2015-12-14

Applicant: Novartis AG

Inventor： Walter Laredo ,  Ali E. Akinay ,  Xuwei Jiang ,  David Jinkerson ,  Vincent Nguyen ,  Douglas Schlueter

IPC: G02B1/04 ,  A61F2/16

CPC classification number: G02B1/041 ,  A61F2/16 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  C08L33/26

Abstract: Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23° C. to about 28° C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Abstract translation: 公开了丙烯酸酯 - 丙烯酰胺共聚物。 它们在室温（约23℃至约28℃）的干燥状态下是刚性的和玻璃状的，但是柔软且非常可变形并且具有高折射率，高耐光性和低老化相关表面 完全水合状态下的光散射。 它们特别适用于制造可通过2.0毫米切口进行输送的湿包装眼内透镜（IOL）。

公开(公告)号：US09921341B2

公开(公告)日：2018-03-20

申请号：US14967760

申请日：2015-12-14

Applicant: Novartis AG

Inventor： Walter Laredo ,  Ali E. Akinay ,  Xuwei Jiang ,  David Jinkerson ,  Vincent Nguyen ,  Douglas Schlueter

IPC: G02B1/04 ,  A61L27/52 ,  A61L27/26 ,  A61L27/50

CPC classification number: G02B1/043 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  G02B1/041 ,  C08L33/26 ,  A61L2/26

Abstract: Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23° C. to about 28° C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

公开(公告)号：US20170242274A1

公开(公告)日：2017-08-24

申请号：US15434098

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Walter R. Laredo ,  Xuwei Jiang ,  Ryan DeSousa

IPC: G02C7/10 ,  G02C7/04 ,  G02B1/04 ,  C07C233/33 ,  C08F283/12

CPC classification number: G02C7/108 ,  C07C225/22 ,  C07C233/33 ,  C07C237/32 ,  C07C237/34 ,  C08F283/124 ,  G02B1/043 ,  G02C7/049

Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

公开(公告)号：US20150151021A1

公开(公告)日：2015-06-04

申请号：US14557676

申请日：2014-12-02

Applicant: Novartis AG

Inventor： Xuwei Jiang ,  Douglas Schlueter

IPC: A61L27/16 ,  A61F2/16

Abstract: Soft hydrophobic acrylic materials with improved resistance to fluid diffusion and suitable mechanical properties that allow deformation upon application of force are disclosed. The acrylic materials are particularly suitable for use in fluid-based accommodating intraocular lenses and comprises combination of a perfluoro-substituted alkyl (meth)acrylate and an alkyl (meth)acrylate, and a cross-linking agent.

Abstract translation: 公开了具有改善的对流体扩散的抵抗力的柔性疏水性丙烯酸材料以及允许在施加力时变形的合适的机械性能。 丙烯酸类材料特别适用于基于流体的容纳人工晶状体，并且包括全氟取代的（甲基）丙烯酸烷基酯和（甲基）丙烯酸烷基酯和交联剂的组合。

公开(公告)号：US10064977B2

公开(公告)日：2018-09-04

申请号：US15006287

申请日：2016-01-26

Applicant: Novartis AG

Inventor： Xuwei Jiang ,  Douglas Schlueter ,  Walter Laredo

IPC: C08F220/30 ,  B29D11/00 ,  A61L27/16 ,  A61L27/50 ,  A61F2/16 ,  A61L27/18 ,  A61L27/26

Abstract: Intraocular lens materials are disclosed. They are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

公开(公告)号：US09289531B2

公开(公告)日：2016-03-22

申请号：US14557704

申请日：2014-12-02

Applicant: Novartis AG

Inventor： Xuwei Jiang ,  Douglas Schlueter ,  Walter Laredo

IPC: A61F2/16 ,  A61L27/16 ,  A61L27/50 ,  A61L27/18 ,  C08F220/30 ,  C08F220/28 ,  C08F236/02 ,  A61F2/14

CPC classification number: A61L27/16 ,  A61F2/14 ,  A61F2/16 ,  A61F2/18 ,  A61L27/18 ,  A61L27/50 ,  A61L2430/16 ,  C08F220/30 ,  C08F236/02 ,  C08F2220/286

Abstract: High refractive index acrylic device materials with reduced glistenings are disclosed. The device materials are particularly suitable for use as ophthalmic or otorhhinolaryngological device materials and comprises a poly(phenyl ether)-containing monomer and/or a poly(phenyl ether)-containing cross-linking agent.

Abstract translation: 公开了具有降低的闪光的高折射率丙烯酸类装置材料。 装置材料特别适合用作眼科或耳鼻喉科装置材料，并且包含含聚（苯基醚）的单体和/或含聚（苯基醚）的交联剂。

公开(公告)号：US10268053B2

公开(公告)日：2019-04-23

申请号：US15434098

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Walter R. Laredo ,  Xuwei Jiang ,  Ryan DeSousa

IPC: C07C233/23 ,  G02C7/10 ,  C07C233/33 ,  C08F283/12 ,  G02B1/04 ,  G02C7/04 ,  C07C225/22 ,  C07C237/32 ,  C07C237/34

Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

公开(公告)号：US09864102B2

公开(公告)日：2018-01-09

申请号：US14967780

申请日：2015-12-14

Applicant: Novartis AG

Inventor： Walter Laredo ,  Ali E. Akinay ,  Xuwei Jiang ,  David Jinkerson ,  Vincent Nguyen ,  Douglas Schlueter

IPC: A61F2/16 ,  G02B1/04 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52

CPC classification number: G02B1/041 ,  A61F2/16 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  C08L33/26

Abstract: Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23° C. to about 28° C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

公开(公告)号：US20160170093A1

公开(公告)日：2016-06-16

申请号：US14967760

申请日：2015-12-14

Applicant: Novartis AG

Inventor： Walter Laredo ,  Ali E. Akinay ,  Xuwei Jiang ,  David Jinkerson ,  Vincent Nguyen ,  Douglas Schlueter

IPC: G02B1/04

CPC classification number: G02B1/043 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  G02B1/041 ,  C08L33/26 ,  A61L2/26

Abstract: Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23° C. to about 28° C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Abstract translation: 公开了丙烯酸酯 - 丙烯酰胺共聚物。 它们在室温（约23℃至约28℃）的干燥状态下是刚性的和玻璃状的，但是柔软且非常可变形并且具有高折射率，高耐光性和低老化相关表面 完全水合状态下的光散射。 它们特别适用于制造可通过2.0毫米切口进行输送的湿包装眼内透镜（IOL）。