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公开(公告)号：US20230372625A1
公开(公告)日：2023-11-23
申请号：US18027528
申请日：2021-10-01
申请人： Novo Nordisk A/S
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M2210/106
摘要： An ingestible jet injection device for introducing a fluid drug formulation into a gastrointestinal wall portion of a living mammal subject comprises an adaptive nozzle, a drug reservoir in flow communication with the nozzle, and a drive arrangement for pressurizing the fluid drug, the drive arrangement being actuatable from an initial state to a released state. The nozzle comprises an elastomeric nozzle member with an axially fixed, radially distensible outlet channel, the channel being fully collapsed when the drive arrangement is in the initial state thereby providing a sealed outlet from the reservoir. The channel opens when the drive arrangement is actuated and the pressure in the reservoir exceeds a given opening pressure level thereby creating a collimated jet stream of fluid drug adapted to penetrate a gastro-intestinal mucosal surface, the cross-sectional area of the channel adapting in response to variation in reservoir pressure.
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公开(公告)号：US20230233821A1
公开(公告)日：2023-07-27
申请号：US18009173
申请日：2021-06-10
申请人： Novo Nordisk A/S
CPC分类号： A61M31/002 , A61K9/4808
摘要： Capsule devices, such as devices suitable for swallowing into a lumen of a body lumen, are generally provided. In some embodiments, the capsule device (100) comprises a tissue interfacing component (130) disposed relative to a capsule housing (110,120). The capsule device (100) may comprise a plurality of elongated spike members (182, 130) advanceable relative to the capsule housing (110,120) from a non-advanced first state to an advanced second state, wherein free ends of the elongated spike members (182, 130) engages tissue of a lumen wall of the body lumen. In some embodiments, the capsule device (100) comprises an actuator (155) coupled to the plurality of elongate spike members (182) and an energy source (140) coupled to the actuator (155) for moving the plurality of elongated spike members (182, 130) to the advanced second state. At least one of the plurality of spike members (182, 130) is configured as a deflectable spike member (182) that is deflected laterally as the deflectable spike member is advanced toward the second state so that the plurality of spike members (182, 130) act by spreading or pinching engagement on tissue between the plurality of spike members, thereby anchoring the capsule device (100) relative to the lumen wall.
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公开(公告)号：US20210260293A1
公开(公告)日：2021-08-26
申请号：US17251902
申请日：2019-06-13
申请人： Novo Nordisk A/S
摘要： The invention relates to a pre-filled injection device for apportioning set dose of a liquid drug. The pre-filled injection device is of the type wherein a permanently mounted injection needle is cleaned in a cleaning reservoir between injections. The purpose of the invention is to provide a mechanism by which the cleaning reservoir can be filled with preservative containing liquid drug from the cartridge upon proximal movement of the needle hub in a linear movement.
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公开(公告)号：US10463807B2
公开(公告)日：2019-11-05
申请号：US15562959
申请日：2016-04-01
申请人： Novo Nordisk A/S
摘要： The invention relates to a pre-filled injection device for apportioning a plurality of set doses of a liquid drug comprising. The housing of the injection device supports a non-replaceable cartridge containing the liquid drug. The cartridge is e.g. secured in a cartridge-holder being a part of the housing. A needle assembly comprising a needle cannula secured in a hub is slidable mounted to slide into contact with the cartridge. The tip of the needle cannula is covered by a telescopically movable shield movable from an extended position to a retracted position. The telescopically movable shield supports a cleaning chamber containing a cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections. The distal end of the housing supports a removable protective cap and the telescopically movable shield is guided relatively to the housing and coupled to the protective cap to follow movement of the protective cap.
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公开(公告)号：US20240342099A1
公开(公告)日：2024-10-17
申请号：US18681845
申请日：2022-08-04
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Declan Gwynne , Jacob Wainer , Graham Arrick , Jesper Windum , Kuldeep Sanger , Adam Bohr , Brian Mouridsen , Nikolaj Eusebius Jakobsen , Morten Revsgaard Frederiksen , Jens Lolle Laursen , Ludwig Erik Aguilar
IPC分类号： A61K9/48
CPC分类号： A61K9/4808
摘要： An ingestible device may include one or more deployable limbs configured to orient the ingestible device in a desired orientation. The one or more limbs may be attached to body of the device and wrap around the device in an initial configuration (e.g., prior to deployment of the one or more limbs). The one or more limbs may be configured to deploy when exposed to a predetermined condition. Once the predetermined condition is met, the one or more limbs may extend outwards away from the body such that the one or more deployed limbs serve to orient the ingestible device.
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公开(公告)号：US20220105330A1
公开(公告)日：2022-04-07
申请号：US17426848
申请日：2020-01-31
申请人： Novo Nordisk A/S
摘要： A medical delivery device suitable for insertion into a lumen of a patient, the medical device (100, 200) comprising a capsule (110, 120, 210, 220) sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member (150, 250, 350) configured for movement relative to the base member along an axis, and an energy source (140, 240, 340) associated with the actuation member for powering the actuation member to move relative to the base member along the axis. The base member and the actuation member define a latch assembly comprising: a) a dissolvable firing member (160, 260, 360), the dissolvable firing member being at least partially dissolvable when subjected to a biological fluid, b) a retainer portion (113, 213, 313) comprised by one of the base member and the actuation member, and c) a movable latch (152, 252, 352) configured for lateral movement relative to the axis, the movable latch defining a first surface with a blocking portion (153, 253, 353), and a second surface (152a, 252a, 352a) configured for interacting with the dissolvable firing member (160, 260, 360). In a pre-firing configuration, the blocking portion (153, 253, 353) of the movable latch engages the retainer portion (113, 213, 313) in a latching engagement, and the second surface (152a, 252a, 352a) of the movable latch interacts with the dissolvable firing member to restrict lateral movement of the movable latch thereby preventing release of the latching engagement. In a firing configuration where the dissolvable firing member (160, 260) has become at least partially dissolved, the movable latch is allowed to move laterally thereby releasing the latching engagement.
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公开(公告)号：US20210154457A1
公开(公告)日：2021-05-27
申请号：US16691514
申请日：2019-11-21
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
摘要： Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.
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公开(公告)号：US20200147298A1
公开(公告)日：2020-05-14
申请号：US16613766
申请日：2018-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).
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公开(公告)号：US10226577B2
公开(公告)日：2019-03-12
申请号：US15035040
申请日：2014-11-13
申请人： Novo Nordisk A/S
摘要： A drug delivery device is provided comprising a housing having an exterior surface, a drug-filled reservoir with an outlet, drug expelling means, and a flexible sheet. On the flexible sheet is formed or mounted input means adapted to be actuated corresponding to an event indicative of drug being expelled, a display adapted to display a time parameter, a processor, and an energy source. The processor is adapted to, based on input from the detection means, control the display to display a time parameter related to the time the event was detected, and the flexible sheet is attached at least in part to the outer surface of the housing.
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公开(公告)号：US20180221563A1
公开(公告)日：2018-08-09
申请号：US15749374
申请日：2016-07-29
申请人： Novo Nordisk A/S
CPC分类号： A61M5/001 , A61M5/20 , A61M5/24 , A61M5/2422 , A61M5/31525 , A61M5/3155 , A61M5/3213 , A61M5/3216 , A61M2005/3126
摘要： The invention relates to a torsion spring driven injection device for apportioning individually set doses of a liquid drug. The injection device has a needle cannula (35) for multiple uses and a cleaning chamber (56) for cleaning the tip of the needle cannula between subsequent injections. The cleaning chamber is filled with preservative containing liquid drug directly from the cartridge (30) in a filling sequence which is executed when the user initiates first use of the injection device. The sequence comprises the step of securing the piston rod guide in an inrotatable position and thereafter moving the cartridge in a proximal direction. Such axial movement of the cartridge without a similar movement of the plunger automatically pumps liquid drug from the cartridge and into the cleaning chamber via the lumen of the needle cannula.
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