公开(公告)号：US20210276954A1

公开(公告)日：2021-09-09

申请号：US17212514

申请日：2021-03-25

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Feng YIN

IPC: C07D209/54 ,  C07C201/12 ,  C07C205/51 ,  C07D207/16

Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

公开(公告)号：US20240132435A1

公开(公告)日：2024-04-25

申请号：US17769124

申请日：2020-10-15

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Muhammad SOHAIL

IPC: C07C49/657 ,  C07D209/34

CPC classification number: C07C49/657 ,  C07D209/34

Abstract: This invention relates to 1,3-cyclohexanedione derivatives and 1,3-cyclopentanedione derivatives that have buffering function in non-aqueous solutions and to the use thereof for tuning the conditions to control chemical events in non-aqueous solutions. One aspect of the invention is a method for buffering a non-aqueous solution, including adding a buffering molecule to the non-aqueous solution, in which the non-aqueous solution contains an organic solvent, the buffering molecule is a 1,3-cyclohexanedione derivative or a 1,3-cyclopentanedione derivative, and the buffering molecule is optionally conjugated to a solid support.

公开(公告)号：US20220306671A1

公开(公告)日：2022-09-29

申请号：US17841241

申请日：2022-06-15

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Sherida JOHNSON

IPC: C07H7/04 ,  C07H1/00

Abstract: The present invention provides a novel process for preparing an oligosaccharide C-glycoside derivative of formula I, comprising reacting a compound of formula II with compound of formula III in the presence of at least one primary or secondary amine and at least one additive [in the formulae, the substituents are as defined herein], and novel oligosaccharide C-glycoside derivatives that can be prepared using the process.

公开(公告)号：US20210017211A1

公开(公告)日：2021-01-21

申请号：US17040346

申请日：2019-03-22

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Sherida JOHNSON

IPC: C07H7/04 ,  C07H1/00

Abstract: The present invention provides a novel process for preparing an oligosaccharide C-glycoside derivative of formula I, comprising reacting a compound of formula II with compound of formula III in the presence of at least one primary or secondary amine and at least one additive [in the formulae, the substituents are as defined herein], and novel oligosaccharide C-glycoside derivatives that can be prepared using the process.

公开(公告)号：US20180118648A1

公开(公告)日：2018-05-03

申请号：US15560868

申请日：2016-02-01

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Dongxin ZHANG

IPC: C07C49/753 ,  C07C49/747 ,  C07C49/255 ,  C07C69/738 ,  C07C227/10 ,  C07C227/30 ,  C07C227/42 ,  C07C229/34 ,  C07D333/22 ,  C07D333/24

CPC classification number: C07C49/753 ,  A61K31/02 ,  A61K31/045 ,  C07C49/255 ,  C07C49/747 ,  C07C69/738 ,  C07C227/10 ,  C07C227/30 ,  C07C227/34 ,  C07C227/42 ,  C07C229/34 ,  C07C2601/10 ,  C07C2601/16 ,  C07D333/22 ,  C07D333/24

Abstract: The present invention relates to novel tertiary alcohol derivatives substituted with aryl and trifluoromethyl, and optical isomers thereof. In addition, the present invention also relates to methods for the preparation and use as enantiomer recognition agent thereof. The present invention provides pharmaceutical composition and use as therapeutically active substance thereof.

公开(公告)号：US20190169125A1

公开(公告)日：2019-06-06

申请号：US16321137

申请日：2016-09-28

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Feng YIN

IPC: C07D209/54 ,  C07D207/16 ,  C07C205/51

Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

公开(公告)号：US20180118703A1

公开(公告)日：2018-05-03

申请号：US15560858

申请日：2016-02-01

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Sherida JOHNSON

IPC: C07D307/22 ,  C07D309/14

CPC classification number: C07D307/22 ,  C07D309/14

Abstract: The present invention can provide novel C-glycoside derivatives which are biologically important under high stereoselective, mild, atom economical condition.

公开(公告)号：US20160251328A1

公开(公告)日：2016-09-01

申请号：US15148716

申请日：2016-05-06

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. CHOUTHAIWALE ,  Fujie TANAKA

IPC: C07D309/28

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.