公开(公告)号：US20190125247A1

公开(公告)日：2019-05-02

申请号：US16224261

申请日：2018-12-18

Applicant: OSAKA CITY UNIVERSITY ,  SHISEIDO COMPANY, LTD.

Inventor： Souichi SAEKI ,  Yusuke HARA ,  Toyonobu YAMASHITA

IPC: A61B5/00 ,  A61B5/026

Abstract: A skin diagnosing device includes an optical unit including: an optical system that uses OCT; an optical mechanism to guide light from the optical unit to skin to scan the skin; a loading device to apply predetermined deformation energy to the skin; a control computation unit to compute tomographic distribution of predetermined status values relating to the skin by controlling driving of the loading device and the optical mechanism and processing optical interference signals output from the optical unit in response to the driving, to compute an evaluation value of the skin based on the tomographic distribution; and a display device to display the evaluation value of the skin. The control computation unit computes the evaluation value by computing mechanical characteristics and a blood flow condition of the skin as the status values and associating the mechanical characteristics and the blood flow condition at a cross-sectional position of the skin.

公开(公告)号：US20170160148A1

公开(公告)日：2017-06-08

申请号：US15437985

申请日：2017-02-21

Applicant: Osaka City University

Inventor： Souichi SAEKI

IPC: G01L1/24 ,  G01N21/21 ,  G01B9/02

CPC classification number: G01L1/24 ,  G01B9/02091 ,  G01B11/168 ,  G01L1/241 ,  G01N21/21

Abstract: A control computation unit causes an optical modulator to change a polarization state to shift a phase of polarized light with which an object is irradiated, computes a spatial gradient of tomographic distribution of phase difference of an interference signal on the basis of phase differences of interference signals each obtained by each phase shift of the polarized light, and visually displays tomographic distribution of spatial gradient in association with tomographic distribution of stress on the display device. The control computation unit computes deformation rate vector distribution at cross-sectional positions of the object on the basis of optical interference signals, and further computes tomographic distribution of strain rate tensor. The control computation unit then computes tomographic distribution of mechanical property value from the tomographic distribution of stress and the tomographic distribution of strain rate tensor, and visually displays the tomographic distribution of mechanical property value.

公开(公告)号：US20180206741A1

公开(公告)日：2018-07-26

申请号：US15743210

申请日：2016-07-11

Applicant: OSAKA CITY UNIVERSITY

Inventor： Souichi SAEKI ,  Masatsugu SHIBA

IPC: A61B5/026 ,  A61B5/00

CPC classification number: A61B5/0261 ,  A61B1/018 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/4238 ,  A61B5/6847 ,  A61B5/6852

Abstract: A cancer invasiveness diagnosis system includes an endoscope; a microtomography probe which is introduced into a body cavity together with the endoscope, the microtomography probe emitting a low-coherence light on a target tissue in which a target tumor is present to obtain an optical interference signal; a determination portion which is configured to obtain a tomography image of the target tissue including the target tumor and a blood flow velocity information in a blood vessel in the tomography image based on the optical interference signal, wherein the determination portion is configured to determine the cancer invasiveness of the target tumor based on the tomography image and the blood flow velocity information.

公开(公告)号：US20200237293A1

公开(公告)日：2020-07-30

申请号：US16829546

申请日：2020-03-25

Applicant: SHISEIDO COMPANY, LTD. ,  UNIVERSITY PUBLIC CORPORATION OSAKA

Inventor： Yusuke HARA ,  Toyonobu YAMASHITA ,  Masato NINOMIYA ,  Souichi SAEKI

IPC: A61B5/00

Abstract: A device of an embodiment includes: an optical mechanism; a control computation unit that controls driving of the optical mechanism, acquires a tomographic image of the skin by processing an optical interference signal from the optical system, and calculates a network of blood vessels on the basis of the tomographic image; and a display device that displays the network of blood vessels. The control computation unit expresses thicknesses of the network of blood vessels by defining, as a blood vessel radius, a radius from a set of blood vessel corresponding coordinates determined to be a blood vessel in the calculation of the network of blood vessels and within which other sets of blood vessel corresponding coordinates are present and, superimposing distinctions based on magnitudes of blood vessel radii from the respective sets of blood vessel corresponding coordinates onto the image of the network of blood vessels.

公开(公告)号：US20200226756A1

公开(公告)日：2020-07-16

申请号：US16830619

申请日：2020-03-26

Applicant: SHISEIDO COMPANY, LTD. ,  UNIVERSITY PUBLIC CORPORATION OSAKA

Inventor： Yusuke HARA ,  Toyonobu YAMASHITA ,  Masato NINOMIYA ,  Souichi SAEKI

IPC: G06T7/00 ,  G06T7/66 ,  G06T7/62 ,  G06T11/00 ,  A61B5/00

Abstract: A device of an embodiment includes: an optical mechanism that guides light from a light source to skin tissue to scan the skin tissue; a control computation unit that controls driving of the optical mechanism, acquires tomographic images of the skin by processing optical interference signals from the optical system, and calculates a network of blood vessels on the basis of the tomographic images; and a display device that displays the network of blood vessels. The control computation unit computes autocorrelation values at coordinates in epidermis corresponding regions of the tomographic images, excludes combinations of tomographic images with the computed autocorrelation values corresponding to predetermined low autocorrelation, computes autocorrelation values at coordinates in dermis corresponding regions, determines coordinates at which the autocorrelation values in the dermis corresponding regions are within a predetermined low correlation range to be blood vessels or blood vessel candidates, and calculates a network of blood vessels.

公开(公告)号：US20200237230A1

公开(公告)日：2020-07-30

申请号：US16830807

申请日：2020-03-26

Applicant: SHISEIDO COMPANY, LTD. ,  UNIVERSITY PUBLIC CORPORATION OSAKA

Inventor： Yusuke HARA ,  Toyonobu YAMASHITA ,  Masato NINOMIYA ,  Souichi SAEKI

IPC: A61B5/00 ,  A61B5/02 ,  G01B9/02

Abstract: A device of an embodiment includes: an optical mechanism; a control computation unit that controls driving of the optical mechanism, acquires a tomographic image of skin by processing an optical interference signal from an optical system, and calculates a network of blood vessels on the basis of the tomographic image; and a display device that displays an image of the network of blood vessels. The control computation unit sets a reference profile obtained by function approximation of an intensity profile in a depth direction of the acquired tomographic image, calculates a difference between an intensity value on the reference profile and an actual intensity value as an outlier V, the intensity values being those in the depth direction in the tomographic image, determines, as blood vessels or blood vessel candidates, coordinates with the outliers V within a predetermined blood vessel determination range, and calculates the network of blood vessels.