公开(公告)号：US20240115872A1

公开(公告)日：2024-04-11

申请号：US18270286

申请日：2021-12-30

Applicant: Ohio State Innovation Foundation

Inventor： Vishwanath Subramaniam ,  Joseph West

IPC: A61N2/02 ,  A61N2/00

CPC classification number: A61N2/02 ,  A61N2/004

Abstract: An implant device (105) such as an antennae or coil of wire (107) is implanted into or around a group of cancerous cells such as a tumor (120). A magnetic field generator (205) such as a magnet or electromagnet is placed (310) close to the implant device such that the implant device is within a magnetic field (215) generated (315) by the magnetic field generator. The magnetic field is changed (330), by rotating or moving the magnetic field generator, such that an electric field is induced within the implant device and the group of cancerous cells. The electric field has been shown to reduce the size or number of the cancerous cells, to reduce the growth rate of the cancerous cells, and to halt or reduce metastasis. The strength and frequency of the electric field can be changed based on the type of cancerous cells or based on how the cancerous cells respond to the implant device.

公开(公告)号：US20180125432A1

公开(公告)日：2018-05-10

申请号：US15845021

申请日：2017-12-18

Applicant: Ohio State Innovation Foundation

Inventor： Vishwanath Subramaniam ,  Joseph West ,  Jennifer McFerran Brock ,  Emily Sequin ,  Duxin Sun ,  Peng Zou ,  Travis Hamilton Jones

IPC: A61B5/00 ,  G01N27/02 ,  A61B5/05

CPC classification number: A61B5/7282 ,  A61B5/05 ,  A61B5/415 ,  A61B5/418 ,  A61B6/4417 ,  A61B6/507 ,  A61B6/566 ,  A61B8/5238 ,  G01N27/025

Abstract: Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

公开(公告)号：US20230295814A1

公开(公告)日：2023-09-21

申请号：US18018707

申请日：2021-07-30

Applicant: Ohio State Innovation Foundation

Inventor： Jonathan Kadowaki ,  Travis Jones ,  Anindita Sengupta ,  Venkat Gopalan ,  Vishwanath Subramaniam

IPC: C25B9/50 ,  C07H21/02 ,  C25B3/25 ,  C25B3/21 ,  C25B11/053 ,  C25B11/061 ,  C25B11/091 ,  C25D9/08

CPC classification number: C25B9/50 ,  C07H21/02 ,  C25B3/25 ,  C25B3/21 ,  C25B11/053 ,  C25B11/061 ,  C25B11/091 ,  C25D9/08

Abstract: Disclosed herein are nanostructured electrodes and methods of making and use thereof. The nanostructured precursor electrodes comprising a copper substrate, a nanostructured copper oxide layer disposed on the copper substrate and a nickel layer disposed on the nanostructured copper oxide layer.

公开(公告)号：US20200290039A1

公开(公告)日：2020-09-17

申请号：US16650950

申请日：2018-10-18

Applicant: Ohio State Innovation Foundation

Inventor： Ayush Garg ,  Travis Jones ,  Sarah Bushman ,  Jessica Ferree ,  Vishwanath Subramaniam ,  Jonathan Song ,  Deepa Subramaniam

IPC: B01L3/00 ,  G01N33/50

Abstract: Disclosed herein are devices and methods for measuring the effect of chemokines and electric fields on cell migration. This approach is inherently non-contact and does not require injection of current. For example, disclosed herein is a device for assessing cell migration that comprises a cell migration chamber and an electromagnet positioned to produce a uniform electric field across the length of the chamber. Also disclosed is a method for assaying a cell that involves loading cells into the disclosed device along with a chemokine in an amount to produce a chemokine gradient, activating the electromagnet to produce an electric field across the cell migration chamber, and imaging the cells to measure the dual effect of the chemokine and the electric field on the cells.