公开(公告)号：US10806755B2

公开(公告)日：2020-10-20

申请号：US14631099

申请日：2015-02-25

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Roberto Meidler ,  Elena Grimberg ,  Oleg Belyaev ,  Yonit Tiberman ,  Israel Nur ,  Tamar Auerbach-Nevo

IPC: A61K35/16 ,  A61K38/48 ,  A61K38/36 ,  C07K14/75 ,  A61L24/10 ,  A61L24/00

Abstract: Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.

公开(公告)号：US11857564B2

公开(公告)日：2024-01-02

申请号：US15840329

申请日：2017-12-13

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Tamar Auerbach-Nevo ,  Tali Negreanu-Gilboa ,  Hadas Alperin ,  Israel Nur

IPC: A61K31/721 ,  A61K33/06 ,  A61P7/04 ,  A61L26/00 ,  A61L15/18 ,  A61K33/14

CPC classification number: A61K31/721 ,  A61K33/06 ,  A61K33/14 ,  A61L15/18 ,  A61L26/0004 ,  A61P7/04 ,  A61L2300/208 ,  A61L2300/418 ,  A61L2400/04 ,  A61K33/06 ,  A61K2300/00 ,  A61K31/721 ,  A61K2300/00 ,  A61K33/14 ,  A61K2300/00

Abstract: Provided are pharmaceutical compositions comprising an anion exchanger and a calcium salt; methods for inducing hemostasis at a site of bleeding by applying to the site of bleeding an effective amount of the compositions; and methods of preparation of the compositions.

公开(公告)号：US11123397B2

公开(公告)日：2021-09-21

申请号：US15700655

申请日：2017-09-11

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc

Inventor： Tamar Auerbach-Nevo ,  Ashley Deanglis ,  Israel Nur

IPC: A61K38/01 ,  A61L26/00 ,  A61L24/00 ,  A61L24/10 ,  A61K9/12 ,  A61K38/36 ,  A61K38/48

Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.

公开(公告)号：US11008560B2

公开(公告)日：2021-05-18

申请号：US15922301

申请日：2018-03-15

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Tamar Auerbach-Nevo ,  Nadav Orr ,  Israel Nur

IPC: C12N9/74 ,  C12Q1/56 ,  G01N33/49 ,  C07K14/745 ,  A61K38/00

Abstract: Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.

公开(公告)号：US10066224B2

公开(公告)日：2018-09-04

申请号：US15051821

申请日：2016-02-24

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Tamar Auerbach-Nevo ,  Nadav Orr ,  Israel Nur

IPC: C12Q1/56 ,  C12N9/74 ,  G01N33/49 ,  C07K14/745 ,  A61K38/00

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C07K14/745 ,  C12Q1/56 ,  C12Y304/21005 ,  G01N33/491 ,  G01N2333/96463

Abstract: Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.

公开(公告)号：US11938165B2

公开(公告)日：2024-03-26

申请号：US17405491

申请日：2021-08-18

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc

Inventor： Tamar Auerbach-Nevo ,  Ashley Deanglis ,  Israel Nur

IPC: A61K38/01 ,  A61K9/12 ,  A61K38/36 ,  A61K38/48 ,  A61L24/00 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61K38/018 ,  A61K9/122 ,  A61K38/014 ,  A61K38/363 ,  A61K38/4833 ,  A61L24/0036 ,  A61L24/10 ,  A61L26/0028 ,  A61L26/0085 ,  C12Y304/21005 ,  A61L2400/04

Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.

公开(公告)号：US11149263B2

公开(公告)日：2021-10-19

申请号：US16712207

申请日：2019-12-12

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Tamar Auerbach-Nevo ,  Nadav Orr ,  Israel Nur

IPC: C12N9/74 ,  C12Q1/56 ,  G01N33/49 ,  C07K14/745 ,  A61K38/00

Abstract: Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.

公开(公告)号：US20180071358A1

公开(公告)日：2018-03-15

申请号：US15700655

申请日：2017-09-11

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc

Inventor： Tamar Auerbach-Nevo ,  Ashley DEANGLIS ,  Israel Nur

IPC: A61K38/01 ,  A61K9/12 ,  A61K38/36 ,  A61K38/48

CPC classification number: A61K38/018 ,  A61K9/122 ,  A61K38/014 ,  A61K38/363 ,  A61K38/4833 ,  A61L24/0036 ,  A61L24/10 ,  A61L26/0028 ,  A61L26/0085 ,  A61L2400/04 ,  C12Y304/21005

Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.