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公开(公告)号：US09914771B2
公开(公告)日：2018-03-13
申请号：US15059668
申请日：2016-03-03
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C07K16/22 , A61K39/395 , A61K51/10 , A61K45/06 , C07K16/18 , C07K16/46 , C12N15/00 , A61K39/00 , A61K47/68
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
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公开(公告)号：US09598497B2
公开(公告)日：2017-03-21
申请号：US14870145
申请日：2015-09-30
CPC分类号： C07K16/30 , A61K39/39533 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/60 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
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公开(公告)号：US09499630B2
公开(公告)日：2016-11-22
申请号：US13974792
申请日：2013-08-23
发明人： Austin L. Gurney
IPC分类号： C07K7/08 , C07K7/64 , C07K14/00 , A61K38/08 , A61K38/12 , A61K38/16 , C07K16/30 , C07K14/47 , C07K14/71 , C07K16/28
CPC分类号： C07K16/30 , C07K14/4702 , C07K14/71 , C07K16/28 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体和其他多肽。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。 还提供筛选方法。
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公开(公告)号：US20160326259A1
公开(公告)日：2016-11-10
申请号：US15003322
申请日：2016-01-21
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Chartes Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/30 , A61K31/7068 , A61K31/337 , A61K39/395 , A61K45/06
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
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公开(公告)号：US08945873B2
公开(公告)日：2015-02-03
申请号：US13782671
申请日：2013-03-01
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： C07H21/04 , C12N7/01 , C12N5/12 , C12N15/09 , C12N15/63 , C12N15/79 , C12P21/08 , C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , C07K16/46 , C07K16/22 , C07K14/705 , C07K14/71 , C07K14/435 , A61K39/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US10730940B2
公开(公告)日：2020-08-04
申请号：US15847335
申请日：2017-12-19
IPC分类号： A61K39/395 , C07K16/22 , C07K16/28 , C07K16/46 , A61K45/06 , A61K31/4745 , A61K31/7068 , A61K39/00 , A61K45/00 , C07K16/18 , C07K16/30
摘要： The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
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公开(公告)号：US09879084B2
公开(公告)日：2018-01-30
申请号：US15401543
申请日：2017-01-09
CPC分类号： C07K16/28 , A61K31/4745 , A61K31/7068 , A61K39/00 , A61K39/395 , A61K39/3955 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
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公开(公告)号：US20170218041A1
公开(公告)日：2017-08-03
申请号：US15406229
申请日：2017-01-13
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/7068 , A61K38/00 , A61K38/177 , A61K39/39591 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01N33/5011
摘要： The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.
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公开(公告)号：US09717794B2
公开(公告)日：2017-08-01
申请号：US14693648
申请日：2015-04-22
发明人： Austin L. Gurney , Aaron K. Sato
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
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公开(公告)号：US09676865B2
公开(公告)日：2017-06-13
申请号：US14308371
申请日：2014-06-18
IPC分类号： C07K16/18 , C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61N5/10 , C07K14/705 , C07K14/715 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
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