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公开(公告)号：US20230280253A1
公开(公告)日：2023-09-07
申请号：US18315911
申请日：2023-05-11
申请人： Optofluidics Inc.
发明人： Thomas Castner , Robert Hart , Colby Ashcroft , Brian DiPaolo , Nathan Wall
CPC分类号： G01N15/0227 , G01N15/14 , G06T7/001 , G06T2207/10056 , G01N2015/1493
摘要： A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.
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公开(公告)号：US12007548B2
公开(公告)日：2024-06-11
申请号：US18059490
申请日：2022-11-29
申请人： OPTOFLUIDICS, INC.
发明人： Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Thomas Castner , Bernardo Cordovez , Christopher Earhart , David Erickson , Robert Hart
IPC分类号： G01B21/24 , G01N15/02 , G01N15/0227 , G01N15/14 , G01N15/1429 , G01N15/1434 , G01N21/64 , G02B21/12 , G02B21/16 , G02B21/24 , G02B21/36 , G01N15/00 , G01N15/10 , G01N21/35 , G01N21/65
CPC分类号： G02B21/367 , G01N15/0227 , G01N15/0272 , G01N15/1425 , G01N15/1429 , G01N15/1434 , G01N15/1436 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N21/6456 , G02B21/12 , G02B21/16 , G02B21/24 , G01N2015/0011 , G01N2015/003 , G01N2015/0053 , G01N2015/0065 , G01N2015/0294 , G01N2015/1006 , G01N2015/1493 , G01N2015/1497 , G01N2021/3595 , G01N21/6452 , G01N21/65 , G01N2201/062
摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
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公开(公告)号：US20190331580A1
公开(公告)日：2019-10-31
申请号：US16394173
申请日：2019-04-25
申请人： Optofluidics Inc.
发明人： Thomas Castner , Robert Hart , Colby Ashcroft , Brian DiPaolo , Nathan Wall
摘要： A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.
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公开(公告)号：US20230236409A1
公开(公告)日：2023-07-27
申请号：US18193946
申请日：2023-03-31
申请人： OPTOFLUIDICS, INC.
发明人： Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Thomas Castner , Bernardo Cordovez , Christopher Earhart , David Erickson , Robert Hart
IPC分类号： G02B21/36 , G01N15/02 , G01N15/14 , G02B21/12 , G02B21/24 , G01N21/64 , G02B21/16 , G01N15/00 , G01N21/35 , G01N21/65 , G01N15/10
CPC分类号： G02B21/367 , G01N15/0272 , G01N15/147 , G02B21/12 , G01N15/1429 , G02B21/24 , G01N15/1425 , G01N15/1475 , G01N15/1434 , G01N21/6456 , G02B21/16 , G01N15/1436 , G01N15/0227 , G01N15/1463 , G01N2015/0011 , G01N2021/3595 , G01N21/65 , G01N2015/1006 , G01N2015/1493 , G01N2015/1497 , G01N2201/062 , G01N2015/0065 , G01N2015/0053 , G01N2015/0294 , G01N21/6452 , G01N2015/003
摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
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公开(公告)号：US20210285884A1
公开(公告)日：2021-09-16
申请号：US17331968
申请日：2021-05-27
申请人： Optofluidics Inc.
发明人： Bernardo Cordovez , Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Robert Hart , Alexey Aprelev
摘要： A method of distinguishing between proteinaceous and non-proteinaceous particulates in a fluid sample includes the steps of acquiring a brightfield background image of a membrane filter, introducing a fluid sample onto the membrane filter, acquiring a brightfield image of filtered particles resting on the membrane filter, generating a particle mask based on the brightfield background image and the brightfield image of filtered particles, introducing a fluorescent dye onto the membrane filter, detecting fluorescence on the particle mask, and distinguishing between proteinaceous and non-proteinaceous particulates based on the detected fluorescence. A method for detecting other types of particles, such as polysorbate particles, silicone oil or protein monomers is also disclosed.
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公开(公告)号：US10890514B2
公开(公告)日：2021-01-12
申请号：US16394173
申请日：2019-04-25
申请人： Optofluidics Inc.
发明人： Thomas Castner , Robert Hart , Colby Ashcroft , Brian DiPaolo , Nathan Wall
摘要： A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.
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公开(公告)号：US12070725B2
公开(公告)日：2024-08-27
申请号：US18315911
申请日：2023-05-11
申请人： Optofluidics Inc.
发明人： Thomas Castner , Robert Hart , Colby Ashcroft , Brian DiPaolo , Nathan Wall
IPC分类号： B01D69/10 , G01N15/0227 , G01N15/14 , G06T7/00
CPC分类号： B01D69/106 , G01N15/0227 , G01N15/14 , G06T7/001 , G01N2015/1493 , G06T2207/10056
摘要： A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.
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公开(公告)号：US20230090141A1
公开(公告)日：2023-03-23
申请号：US18059490
申请日：2022-11-29
申请人： OPTOFLUIDICS, INC.
发明人： Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Thomas Castner , Bernardo Cordovez , Christopher Earhart , David Erickson , Robert Hart
摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
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公开(公告)号：US11513333B2
公开(公告)日：2022-11-29
申请号：US15438092
申请日：2017-02-21
申请人： OPTOFLUIDICS, INC.
发明人： Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Thomas Castner , Bernardo Cordovez , Christopher Earhart , David Erickson , Robert Hart
IPC分类号： G01B21/24 , G02B21/36 , G01N15/02 , G02B21/24 , G01N15/14 , G01N21/64 , G02B21/12 , G02B21/16 , G01N21/65 , G01N15/00 , G01N21/35 , G01N15/10
摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
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公开(公告)号：US20210102881A1
公开(公告)日：2021-04-08
申请号：US17116203
申请日：2020-12-09
申请人： Optofluidics Inc.
发明人： Thomas Castner , Robert Hart , Colby Ashcroft , Brian DiPaolo , Nathan Wall
摘要： A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.
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