公开(公告)号：US12007548B2

公开(公告)日：2024-06-11

申请号：US18059490

申请日：2022-11-29

申请人： OPTOFLUIDICS, INC.

发明人： Colby Ashcroft ,  Brian DiPaolo ,  Gjergji Konica ,  Thomas Castner ,  Bernardo Cordovez ,  Christopher Earhart ,  David Erickson ,  Robert Hart

IPC分类号： G01B21/24 ,  G01N15/02 ,  G01N15/0227 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/64 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36 ,  G01N15/00 ,  G01N15/10 ,  G01N21/35 ,  G01N21/65

CPC分类号： G02B21/367 ,  G01N15/0227 ,  G01N15/0272 ,  G01N15/1425 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1463 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6456 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G01N2015/0011 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0294 ,  G01N2015/1006 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2021/3595 ,  G01N21/6452 ,  G01N21/65 ,  G01N2201/062

摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.

公开(公告)号：US20170227750A9

公开(公告)日：2017-08-10

申请号：US14455907

申请日：2014-08-10

申请人： Jianfeng Zhang

发明人： Jianfeng Zhang

IPC分类号： G02B21/00 ,  G01B9/04 ,  G01N15/02 ,  G01N33/18 ,  G01N21/64

CPC分类号： G02B21/0076 ,  G01N15/0227 ,  G01N21/6402 ,  G01N21/643 ,  G01N21/6458 ,  G01N33/1833 ,  G01N2015/003 ,  G02B21/008

摘要： The invention is a system and method to measure oil content in water utilizing the fluorescence of oil emitted under excitation by laser. Oil and water mixture is transferred through the system to a measurement section in a microscope, which produces high resolution 3-dimensional images of the oil and water mixture with the fluorescence. The images are analyzed to calculate the amount of oil in water and oil droplets distribution. The image is also analyzed to distinguish oil coated solids from oil droplets, and to calculate the sizes and volumes of the solids.

公开(公告)号：US20170146442A1

公开(公告)日：2017-05-25

申请号：US15319512

申请日：2015-06-16

申请人： ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Philippe Marc NERIN ,  Nicolas BREMOND ,  Jérôme BIBETTE ,  Jean BAUDRY ,  Rory GILES

IPC分类号： G01N15/14 ,  G01N15/10

CPC分类号： G01N15/14 ,  G01N15/1012 ,  G01N15/1459 ,  G01N2015/003 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1018

摘要： The present invention relates to the use of a solution of liquid particles in suspension for the control, calibration and/or performance of physical, in particular optical, measurements in a flow cytometry device for analysis of biological cells, said solution comprising liquid particles (21) of a first liquid phase dispersed in a second liquid phase, said liquid particles (21) having physical, chemical and/or biochemical properties that enable the attainment of physical measurements in said flow cytometry device similar to measurements obtained with biological cells, and said liquid particles (21), having a diameter for which the coefficient of variation within the solution of liquid particles in suspension is less than 10%.The invention also relates to a measurement method and a flow cytometry device implementing the solution of liquid particles in suspension.

公开(公告)号：US08576396B2

公开(公告)日：2013-11-05

申请号：US13129933

申请日：2009-11-19

申请人： Diethelm Fröse

发明人： Diethelm Fröse

IPC分类号： G01N21/00

CPC分类号： G01N15/0205 ,  G01N21/0303 ,  G01N21/53 ,  G01N2015/003 ,  G01N2015/035

摘要： The invention relates to a device and to a method for measuring the scattered light about molecules present in a suspension, wherein the suspension is fed through a measurement cell. The measurement cell is produced as a segment of a curved surface, particularly an ellipsoid, a hyperbolic shape, a parabolic shape, or a circle, and comprises a curved and a flat surface. Light-sensitive detectors are disposed about the curved surface and capture the scattered light.

摘要翻译： 本发明涉及一种用于测量悬浮液中存在的分子的散射光的装置和方法，其中悬浮液通过测量池进料。 测量单元被制成曲面的一段，特别是椭圆形，双曲形，抛物线形或圆形，并且包括弯曲和平坦的表面。 光敏检测器围绕弯曲表面设置并捕获散射光。

公开(公告)号：US20120135535A1

公开(公告)日：2012-05-31

申请号：US13254403

申请日：2010-01-14

申请人： David G. Grier ,  Fook Chiong Cheong ,  Ke Xiao

发明人： David G. Grier ,  Fook Chiong Cheong ,  Ke Xiao

IPC分类号： G06K9/46 ,  H04N7/18 ,  G01N21/00

CPC分类号： G01N15/1475 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/003 ,  G01N2015/0065 ,  G01N2015/1445 ,  G01N2015/1454 ,  G01N2015/1493 ,  G01N2015/1497 ,  G02B21/0056 ,  G02B21/0068 ,  G02B21/008 ,  G03H1/0005 ,  G03H2001/005

摘要： An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.

摘要翻译： 可以使用在线全息显微镜逐帧分析视频流来跟踪各个胶体颗粒的三维运动。 该系统和方法可以提供实时的纳米分辨率，同时测量粒径和折射率。 通过结合使用Lorenz-Mie分析与选定的硬件和软件方法的组合，该分析可以近乎实时地进行。 有效的粒子识别方法以足够的精度自动进行初始位置估计，以实现无人值守的全息跟踪和表征。

公开(公告)号：US20110242535A1

公开(公告)日：2011-10-06

申请号：US13129933

申请日：2009-11-19

申请人： Diethelm Fröse

发明人： Diethelm Fröse

IPC分类号： G01N21/01

CPC分类号： G01N15/0205 ,  G01N21/0303 ,  G01N21/53 ,  G01N2015/003 ,  G01N2015/035

摘要： The invention relates to a device and to a method for measuring the scattered light about molecules present in a suspension, wherein the suspension is fed through a measurement cell. The measurement cell is produced as a segment of a curved surface, particularly an ellipsoid, a hyperbolic shape, a parabolic shape, or a circle, and comprises a curved and a flat surface. Light-sensitive detectors are disposed about the curved surface and capture the scattered light.

摘要翻译： 本发明涉及一种用于测量悬浮液中存在的分子的散射光的装置和方法，其中悬浮液通过测量池进料。 测量单元被制成曲面的一段，特别是椭圆形，双曲形，抛物线形或圆形，并且包括弯曲和平坦的表面。 光敏检测器围绕弯曲表面设置并捕获散射光。

公开(公告)号：US06915214B2

公开(公告)日：2005-07-05

申请号：US10440528

申请日：2003-05-19

申请人： Andrei S. Dukhin ,  Philip J. Goetz

发明人： Andrei S. Dukhin ,  Philip J. Goetz

IPC分类号： G01N15/10 ,  G01N29/028 ,  G01N31/00 ,  G06F19/00

CPC分类号： G01N27/447 ,  G01N15/00 ,  G01N15/1031 ,  G01N29/00 ,  G01N2015/003 ,  G01N2291/02416 ,  G01N2291/02872

摘要： A method is described which applies the combination of Electroacoustic and Complex Conductivity measurements to characterize particle electric surface properties, such as ζ-potential, and bulk properties, such as the dielectric permittivity, in systems where conductivity data is required for applying an appropriate theoretical model for calculating output parameters from the measured data. In particular, this is important in low conducting systems for which the double layer thickness exceeds the particle radius or in the systems where particles have either high bulk dielectric permittivity or high conductivity.

摘要翻译： 描述了一种方法，其应用电声和复电导率测量的组合来表征在应用适当的理论模型所需的电导率数据的系统中的颗粒电表面性质，例如ζ电位和体性质，例如介电常数 用于从测量数据计算输出参数。 特别地，这在双层厚度超过粒子半径的低导电系统中或者在具有高体积介电常数或高导电性的体系中是重要的。

公开(公告)号：US06766702B2

公开(公告)日：2004-07-27

申请号：US09907071

申请日：2001-07-16

申请人： Jost Heintzenberg ,  Robert J. Charlson ,  Frank Stratmann ,  Manfred Wendisch ,  Sabine Wurzler

发明人： Jost Heintzenberg ,  Robert J. Charlson ,  Frank Stratmann ,  Manfred Wendisch ,  Sabine Wurzler

IPC分类号： G01N1502

CPC分类号： G01N15/0205 ,  G01N2015/0026 ,  G01N2015/003 ,  G01N2015/0046 ,  G01N2015/0053 ,  G01N2015/0092

摘要： The present invention relates to a method for investigating the behavior of particles or droplets in a gas-vapor mixture inside a flow device, which is useful for studying cloud dynamical and microphysical processes. The invention allows adjustment and/or control of the thermodynamic system parameters based on the observed behavior of an internal standard with known properties, thus achieving a well-defined vapor concentration and saturation field inside the flow device. By injecting particles or droplets to be investigated into this well defined flow device, and measuring the size of the particles or droplets, the activation and growth or shrinking behavior of the particles or droplets may be determined using a mathematical model of the fluid, thermodynamic, and chemical conditions of the flow device.

摘要翻译： 本发明涉及一种用于研究流动装置内的气体 - 蒸气混合物中的颗粒或液滴的行为的方法，其用于研究云动态和微物理过程。 本发明允许基于具有已知特性的内标的观察行为来调节和/或控制热力学系统参数，从而在流动装置内实现明确的蒸气浓度和饱和场。 通过将待研究的颗粒或液滴注入到这个良好限定的流动装置中，并测量颗粒或液滴的尺寸，可以使用流体，热力学的数学模型来确定颗粒或液滴的活化和生长或收缩行为， 和流动装置的化学条件。

公开(公告)号：US20030020050A1

公开(公告)日：2003-01-30

申请号：US09907071

申请日：2001-07-16

发明人： Jost Heintzenberg ,  Robert J. Charlson ,  Frank Stratmann ,  Manfred Wendisch ,  Sabine Wurzler

IPC分类号： G01N035/08 ,  G01N037/00

CPC分类号： G01N15/0205 ,  G01N2015/0026 ,  G01N2015/003 ,  G01N2015/0046 ,  G01N2015/0053 ,  G01N2015/0092

摘要： The present invention relates to a method for investigating the behavior of particles or droplets in a gas-vapor mixture inside a flow device, which is useful for studying cloud dynamical and microphysical processes. The invention allows adjustment and/or control of the thermodynamic system parameters based on the observed behavior of an internal standard with known properties, thus achieving a well-defined vapor concentration and saturation field inside the flow device. By injecting particles or droplets to be investigated into this well defined flow device, and measuring the size of the particles or droplets, the activation and growth or shrinking behavior of the particles or droplets may be determined using a mathematical model of the fluid, thermodynamic, and chemical conditions of the flow device.

摘要翻译： 本发明涉及一种用于研究流动装置内的气体 - 蒸气混合物中的颗粒或液滴的行为的方法，其用于研究云动态和微物理过程。 本发明允许基于具有已知特性的内标的观察行为来调节和/或控制热力学系统参数，从而在流动装置内实现明确的蒸气浓度和饱和场。 通过将待研究的颗粒或液滴注入到这个良好限定的流动装置中，并测量颗粒或液滴的尺寸，可以使用流体，热力学的数学模型来确定颗粒或液滴的活化和生长或收缩行为， 和流动装置的化学条件。

公开(公告)号：US20020147563A1

公开(公告)日：2002-10-10

申请号：US10079812

申请日：2002-02-22

发明人： Dietmar Lerche ,  Volker Berwald

IPC分类号： G06F015/00

CPC分类号： G01N15/0227 ,  G01N15/04 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/51 ,  G01N21/59 ,  G01N2015/0011 ,  G01N2015/0026 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2015/0092 ,  G01N2015/0288 ,  G01N2021/3181 ,  G01N2021/5969

摘要： The invention relates to methods and devices for accelerated stability analysis, and in particular to a qualitative and quantitative direct estimation/identification of separation processes of disperse material systems (such as liquid-solid, liquid-liquid or liquid-gaseous). The invention also relates to methods and devices for the classification and quantitative characterization of slow, as well as rapid separation phenomena of disperse material systems of different volume concentration. Exemplary fields of application concern the development, selection and optimization of destabilizers, stabilizers and novel formulations for dispersions, as well as quality and process control (such as in the chemical, pharmaceutical, biotechnological, cosmetic and food industries), as well as in the process technology for separation and treatment processes.

摘要翻译： 本发明涉及用于加速稳定性分析的方法和装置，特别涉及分散材料体系（例如液固，液液或液态 - 气体）分离过程的定性和定量的直接估计/鉴定。 本发明还涉及用于分级和定量表征不同体积浓度的分散材料体系的缓慢以及快速分离现象的方法和装置。 示例性应用领域涉及不稳定剂，稳定剂和用于分散体的新配方以及质量和过程控制（例如在化学，制药，生物技术，化妆品和食品工业）中的开发，选择和优化，以及在 分离处理工艺技术。