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公开(公告)号：US20250066486A1
公开(公告)日：2025-02-27
申请号：US18825514
申请日：2024-09-05
Applicant: Orionis Biosciences Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
IPC: C07K16/28 , A61K38/17 , A61K38/21 , A61K39/395 , A61K39/40 , A61K39/42 , A61P25/00 , C07K14/47 , C07K16/00 , C07K16/18
Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
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公开(公告)号：US20220249609A1
公开(公告)日：2022-08-11
申请号：US17620329
申请日：2020-06-18
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai KLEY , Jan TAVERNIER , Leander HUYGHE
Abstract: The present invention relates, in part, to chimeric protein or chimeric protein complex comprising a CD13 targeting moiety and a signaling agent (e.g., without limitation TNF or IFN-γ) and methods of treatment using such compositions.
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公开(公告)号：US20220119472A1
公开(公告)日：2022-04-21
申请号：US17292017
申请日：2019-11-07
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai KLEY , Jan TAVERNIER , Anje CAUWELS , Lennart ZABEAU , Erik DEPLA
IPC: C07K14/56 , C07K16/28 , A61P35/00 , C07K14/565
Abstract: The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.
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公开(公告)号：US20230295304A1
公开(公告)日：2023-09-21
申请号：US17938109
申请日：2022-10-05
Applicant: Orionis Biosciences Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
IPC: C07K16/28 , A61P35/00 , C07K14/56 , C07K14/565
CPC classification number: C07K16/2827 , A61P35/00 , C07K14/56 , C07K14/565 , A61K2039/505
Abstract: The present invention relates, in part, to agents that bind PD-1 or PD-L1 and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the PD-1 or PD-L1 binding agents and their use in the treatment of various diseases.
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公开(公告)号：US20240368277A1
公开(公告)日：2024-11-07
申请号：US18625774
申请日：2024-04-03
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Jan TAVERNIER
Abstract: The present invention relates, in part, to agents that bind SIRP1α and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the SIRP1α targeting moiety and their use in the treatment of various diseases.
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Patent Agency Ranking
公开(公告)号：US20230142099A1
公开(公告)日：2023-05-11
申请号：US18060694
申请日：2022-12-01
Applicant: Orionis Biosciences Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
CPC classification number: C07K16/2815 , C07K14/56 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2319/02
Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
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7.发明申请公开(公告)号：US20220177550A1
公开(公告)日：2022-06-09
申请号：US17598570
申请日：2020-03-27
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Erik DEPLA , Lennart ZABEAU , Jan TAVERNIER
IPC: C07K16/00 , A61P37/04 , C07K14/545 , C07K14/56 , C12N9/12
Abstract: Chimeric proteins or chimeric protein complexes, such as an Fc-based chimeric protein complexes directed to FMS-like tyrosine kinase 3 (FLT3), optionally composed of a FMS-like tyrosine kinase 3L (FLT3L) domain and human cytokines, which find use in, e.g., cancer treatments, are described.
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公开(公告)号：US20210230291A1
公开(公告)日：2021-07-29
申请号：US17133782
申请日：2020-12-24
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Lennart ZABEAU , Jan TAVERNIER
Abstract: The present invention relates, in part, to chimeric proteins comprising consensus interferon, or a variant thereof, and their use as therapeutic agents.
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公开(公告)号：US20240360224A1
公开(公告)日：2024-10-31
申请号：US18668770
申请日：2024-05-20
Applicant: Orionis Biosciences Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
IPC: C07K16/28 , A61K38/17 , A61K38/21 , A61K39/395 , A61K39/40 , A61K39/42 , A61P25/00 , C07K14/47 , C07K16/00 , C07K16/18
CPC classification number: C07K16/2851 , A61K38/17 , A61K38/212 , A61K38/215 , A61K39/395 , A61K39/40 , A61K39/42 , A61P25/00 , C07K14/4713 , C07K16/00 , C07K16/18 , C07K2319/00
Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various disease.
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公开(公告)号：US20220153801A1
公开(公告)日：2022-05-19
申请号：US17598573
申请日：2020-03-27
Applicant: Orionis Biosciences, Inc. , Orionis Biosciences BV
Inventor： Nikolai KLEY , Erik DEPLA , Lennart ZABEAU , Jan TAVERNIER
Abstract: The present invention relates, in part, to chimeric protein complexes including an anti-Clec9A targeting moiety, a modified Fc domain, and a modified human IFNα and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric protein complexes and their use in the treatment of various diseases.
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