公开(公告)号：US06750336B2

公开(公告)日：2004-06-15

申请号：US10285571

申请日：2002-11-01

申请人： Osamu Sato ,  Kiyotaka Hatakeda ,  Yutaka Ikushima ,  Kazuo Torii

发明人： Osamu Sato ,  Kiyotaka Hatakeda ,  Yutaka Ikushima ,  Kazuo Torii

IPC分类号： C07D20104

CPC分类号： C07D201/04 ,  Y02P20/582

摘要： A method for producing a lactam by using an organic solvent as a substrate solution, which makes it possible to introduce a high-concentration oxime into flowing high-temperature and high-pressure water, thereby allowing the high-concentration lactam to be synthesized with a high efficiency. With this method, the lactam is continuously synthesized at a high rate from the oxime under high-temperature and high-pressure water mixture conditions within a temperature range of no less than 250° C. and a pressure range of no less than 15 MPa.

摘要翻译： 通过使用有机溶剂作为底物溶液制备内酰胺的方法，可以将高浓度肟引入流动的高温高压水中，从而使高浓度的内酰胺与 高效率。 通过该方法，在不低于250℃的温度范围和不低于15MPa的压力范围内，在高温和高压水混合条件下，从肟连续合成内酰胺。

公开(公告)号：US07022842B2

公开(公告)日：2006-04-04

申请号：US10450450

申请日：2001-03-07

申请人： Kiyotaka Hatakeda ,  Osamu Sato ,  Mitsuhiro Kanakubo ,  Yutaka Ikushima ,  Kazuo Torii

发明人： Kiyotaka Hatakeda ,  Osamu Sato ,  Mitsuhiro Kanakubo ,  Yutaka Ikushima ,  Kazuo Torii

IPC分类号： C07B43/06 ,  C07D205/08

CPC分类号： C07D201/08 ,  Y02P20/582

摘要： It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200° C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

摘要翻译： 本发明的一个目的是提供一种合成β-内酰胺的方法和一种在高温和高压水中制备β-内酰胺的方法，本发明涉及一种β-内酰胺合成方法， 其特征在于β-内酰胺是通过在高温和高压下在水中使β-氨基酸反应合成的，该方法的进一步特征在于通过使β-氨基酸在高温和高压下环化β-氨基酸来高速合成β-内酰胺 在温度范围为200℃以上且压力范围为10MPa以上的高温高压下的水，本发明还涉及β-内酰胺的制造方法，其特征在于， 该β-内酰胺通过在高温和高压下在水中使β-氨基酸反应合成，然后使用柱分离介质分离和纯化。

公开(公告)号：US07084269B2

公开(公告)日：2006-08-01

申请号：US10471750

申请日：2002-03-05

申请人： Kiyotaka Hatakeda ,  Osamu Sato ,  Yutaka Ikushima ,  Kazuo Torii

发明人： Kiyotaka Hatakeda ,  Osamu Sato ,  Yutaka Ikushima ,  Kazuo Torii

IPC分类号： C07D201/04

CPC分类号： C07D201/04

摘要： It is an object of the present invention to provide an efficient method of continuously producing a lactam in high-temperature high-pressure water, and the present invention relates to a method of producing a lactam characterized by efficiently synthesizing the lactam while suppressing oxime hydrolysis by introducing an oxime as a reaction substrate and an acid into a reaction zone through which high-temperature high-pressure water is flowing, or introducing an oxime into flowing high-temperature high-pressure water containing an acid, thus raising the temperature of the reaction substrate to put the reaction substrate into a prescribed high-temperature high-pressure state within a short time and subjecting the reaction substrate to reaction; through the method, the lactam can be efficiently and continuously synthesized at a high rate from the oxime using an acid catalyst in water at a high temperature of at least 250° C. and a high pressure of at least 15 MPa.

摘要翻译： 本发明的目的是提供一种在高温高压水中连续生产内酰胺的有效方法，本发明涉及一种制备内酰胺的方法，其特征在于在抑制肟水解的同时有效地合成内酰胺 将肟作为反应基质和酸引入高温高压水流过的反应区，或将肟引入流入含有酸的高温高压水中，从而提高反应温度 将反应基材在短时间内放入规定的高温高压状态，使反应基板反应; 通过该方法，可以使用酸催化剂在高温下在高温至少250℃，高压至少15MPa的水中，以高速从肟高效连续地合成内酰胺。

公开(公告)号：US07045622B2

公开(公告)日：2006-05-16

申请号：US10469533

申请日：2001-03-23

申请人： Kiyotaka Hatakeda ,  Osamu Sato ,  Yutaka Ikushima ,  Kazuo Torii

发明人： Kiyotaka Hatakeda ,  Osamu Sato ,  Yutaka Ikushima ,  Kazuo Torii

IPC分类号： C07D201/04 ,  C07D223/10

CPC分类号： C07D201/06 ,  C07D201/04 ,  C07D223/10

摘要： It is an object of the present invention to provide a method of continuously producing a lactam in high-temperature high-pressure water, and the present invention relates to a method for producing a lactam characterized by selectively synthesizing the lactam without bringing about hydrolysis by introducing an oxime into flowing high-temperature high-pressure water, wherein the lactam is continuously synthesized at a high rate from the oxime in water at a high temperature of at least 250° C. and a high pressure of at least 12 MPa.

摘要翻译： 本发明的目的是提供一种在高温高压水中连续生产内酰胺的方法，本发明涉及一种制备内酰胺的方法，其特征在于，通过引入不引起水解而选择性合成内酰胺 将肟流入高温高压水中，其中在至少250℃的高温和至少12MPa的高压下，从肟在水中以高速连续合成内酰胺。

公开(公告)号：US07071350B2

公开(公告)日：2006-07-04

申请号：US10450157

申请日：2001-10-30

申请人： Kiyotaka Hatakeda ,  Osamu Sato ,  Mitsuhiro Kanakubo ,  Yutaka Ikushima ,  Kazuo Torii

发明人： Kiyotaka Hatakeda ,  Osamu Sato ,  Mitsuhiro Kanakubo ,  Yutaka Ikushima ,  Kazuo Torii

IPC分类号： C07C61/00 ,  C07C229/00 ,  C07C205/00

CPC分类号： C07C227/08 ,  C07C227/40 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26

摘要： The present invention relates to a method for introducing an amino group into an organic acid or an organic ester by reacting an organic salt or an organic ester and ammonia under high-temperature and high-pressure water conditions, a method for synthesizing an amino acid or an amino ester by the above method, and a method for manufacturing an amino acid compound by synthesizing an amino acid or an amino ester by the above method and separating and refining it with an ion exchange resin.

摘要翻译： 本发明涉及通过有机盐或有机酯与氨在高温高压水条件下反应而将氨基引入有机酸或有机酯的方法，用于合成氨基酸或 通过上述方法的氨基酯，以及通过用上述方法合成氨基酸或氨基酯制备氨基酸化合物的方法，并用离子交换树脂分离和精制。

公开(公告)号：US06774262B1

公开(公告)日：2004-08-10

申请号：US09659821

申请日：2000-09-11

申请人： Yutaka Ikushima ,  Osamu Sato ,  Kiyotaka Hatakeda

发明人： Yutaka Ikushima ,  Osamu Sato ,  Kiyotaka Hatakeda

IPC分类号： C07C51235

CPC分类号： C07C29/147 ,  C07C51/16 ,  Y02P20/544 ,  C07C63/06 ,  C07C29/14 ,  C07C33/22

摘要： The invention provides a method of increasing the reaction rate of an organic synthesis reaction by utilizing supply of OH− from water in the absence of catalyst without adding a basic catalyst in supercritical water or subcritical water of at least 350 ° C., and a method of generating alcohol and carboxylic acid with high reaction rate by performing a Cannizzaro reaction in the absence of catalyst without adding a basic catalyst in supercritical water, and to a method of synthesis of alcohol and carboxylic acid from an aldehyde in the absence of catalyst without adding a basic catalyst near the critical point (375 to 380 ° C., 22.5 to 25 MPa) of supercritical water.

摘要翻译： 本发明提供了一种通过在不存在催化剂的情况下从水中提供OH而不增加至少350℃的超临界水或亚临界水中的碱性催化剂来提高有机合成反应的反应速率的方法，以及 通过在不存在催化剂的情况下进行坎尼扎罗反应而不在超临界水中添加碱性催化剂的情况下以高反应速度生成醇和羧酸的方法，以及在不存在催化剂的情况下由醛合成醇和羧酸的方法 在临界点附近（375〜380℃，22.5〜25MPa）的超临界水附近不添加碱性催化剂。

公开(公告)号：US5403739A

公开(公告)日：1995-04-04

申请号：US118669

申请日：1993-09-10

申请人： Yutaka Ikushima ,  Norio Saito ,  Kiyotaka Hatakeda ,  Shota Ito

发明人： Yutaka Ikushima ,  Norio Saito ,  Kiyotaka Hatakeda ,  Shota Ito

IPC分类号： C12P7/62 ,  C07C69/58 ,  C12P7/64 ,  C12P41/00 ,  C12R1/72

CPC分类号： C12P7/6418 ,  C12P41/004 ,  C12P7/6436 ,  Y02P20/544

摘要： A primary terpene alcohol such as citronellol can be enzymatically esterified with a higher fatty acid such as oleic acid in the presence of lipase in an atmosphere of supercritical carbon dioxide as the reaction medium at a high reaction velocity. The influence of the temperature and pressure of the atmosphere on the reaction velocity was studied. When the starting primary terpene alcohol is a racemic compound of the optical isomers having chirality as in (.+-.)-citronellol, efficient racemic resolution can be achieved by suitably selecting the temperature and pressure in the vicinity of the critical point of carbon dioxide to give the (S)-(-)-ester having an optical purity of almost 100% when the starting terpene alcohol is (.+-.)-citronellol.

摘要翻译： 在超临界二氧化碳的气氛中作为反应介质以高反应速度，可以在脂肪酶存在下，用诸如油酸的高级脂肪酸例如香茅醇类的主要萜烯醇进行酶促酯化。 研究了大气温度和压力对反应速度的影响。 当起始原始萜烯醇是具有如（+/-） - 香茅醇中的手性的旋光异构体的外消旋化合物时，可以通过适当地选择二氧化碳临界点附近的温度和压力至 当起始萜烯醇为（+/-） - 香茅醇时，得到光学纯度几乎为100％的（S） - （ - ） - 酯。

公开(公告)号：US06300523B1

公开(公告)日：2001-10-09

申请号：US09427761

申请日：1999-10-27

申请人： Yutaka Ikushima ,  Osamu Sato

发明人： Yutaka Ikushima ,  Osamu Sato

IPC分类号： C07C4500

CPC分类号： C07C45/52 ,  B01J3/008 ,  Y02P20/544 ,  Y10S210/908

摘要： This invention is intended to provide a method for producing pinacoline by means of pinacol rearrangement in supercritical water, which affords an extremely high reaction rate without the addition of high concentrations of acid, and this invention is directed to a method for increasing the reaction rate during organic synthesis by utilizing the supply of protons from water under noncatalytic conditions in supercritical water, a method of pinacol rearrangement comprising the production of pinacoline by pinacol rearrangement under noncatalytic conditions without the addition of an acid catalyst in supercritical water, and a method of synthesis comprising the production of cyclic compounds from pinacol under noncatalytic conditions without the addition of an acid catalyst around the critical point (375 to 380° C., 22.5 to 25 MPa) in supercritical water.

摘要翻译： 本发明旨在提供一种在超临界水中通过频哪醇重排生产pinacoline的方法，其提供极高的反应速率而不加入高浓度的酸，本发明涉及一种提高反应速率的方法 利用在超临界水中的非催化条件下从水中提供质子的有机合成，包括在非催化条件下在非催化条件下通过频哪醇重排制备频哪醇的方法，而不在超临界水中加入酸催化剂，以及合成方法，包括 在非催化条件下从频哪醇生产环状化合物，而不在超临界水中在临界点（375至380℃，22.5至25MPa）附近加入酸催化剂。

公开(公告)号：US07148387B2

公开(公告)日：2006-12-12

申请号：US10854179

申请日：2004-05-27

申请人： Kenta Takahashi ,  Yutaka Ikushima

发明人： Kenta Takahashi ,  Yutaka Ikushima

IPC分类号： C07C29/04 ,  C07C29/03

CPC分类号： C07C29/04 ,  C07C2601/14 ,  Y02P20/584 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12 ,  C07C31/125 ,  C07C31/1355 ,  C07C31/276 ,  C07C33/22 ,  C07C33/26 ,  C07C33/24

摘要： Discloses a process for efficiently producing a hydroxyl group containing compound with a simple apparatus and simple procedures using a very small amount of a catalyst, which process reduces a catalyst recovering step and a catalyst neutralization step vastly and does not require catalyst regeneration and catalyst exchange.The process for producing a hydroxyl group containing compound comprises allowing an aqueous solution containing 1 ppb to 500 ppm of an acid catalyst to react with an aliphatic double bond having compound in a molar ratio (water/aliphatic double bond having compound) of water to aliphatic double bond having compound of from 1 to 50, at a reaction temperature of from 200 to 600° C. under a reaction pressure of from 1 to 100 MPa and thereby conducting hydration reaction of the aliphatic double bond containing compound with water.

摘要翻译： 公开了使用极少量催化剂的简单装置和简单的方法有效地制备含羟基化合物的方法，该方法大大减少了催化剂回收步骤和催化剂中和步骤，并且不需要催化剂再生和催化剂交换。 制备含羟基化合物的方法包括使含有1ppb至500ppm酸催化剂的水溶液与具有化合物的摩尔比（具有化合物的水/脂族双键）的脂族双键与脂族双键反应 化合物为1-50的双键，反应温度为200-600℃，反应压力为1-100MPa，由此使含脂肪族双键的化合物与水进行水合反应。