公开(公告)号：US20240360115A1

公开(公告)日：2024-10-31

申请号：US18764292

申请日：2024-07-04

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C07D413/06 ,  A61K31/341 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00

CPC classification number: C07D413/06 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  A61K31/341 ,  A61K2300/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US11339146B2

公开(公告)日：2022-05-24

申请号：US16877291

申请日：2020-05-18

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: A61K31/501 ,  C07D413/06 ,  C07D237/14 ,  C07D207/38 ,  C07D307/60 ,  C07D307/66 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D307/30 ,  C07D307/58 ,  C07D405/06 ,  A61K45/06 ,  C12N7/00 ,  C07D207/36 ,  C07D207/456 ,  C07D317/64 ,  C07D417/06 ,  C07D471/04 ,  A61P35/02 ,  C07D209/48 ,  C07D231/08 ,  A61K31/341

Abstract: Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20180305345A1

公开(公告)日：2018-10-25

申请号：US15542480

申请日：2016-01-26

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Fabrice Le Boeuf ,  John C. Bell ,  Andrew Macklin ,  Jeffrey Smith

IPC: C07D413/06 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D471/04 ,  A61P35/02

CPC classification number: C07D413/06 ,  A61K31/341 ,  A61K31/4015 ,  A61K31/402 ,  A61K2300/00 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US12195451B2

公开(公告)日：2025-01-14

申请号：US17710386

申请日：2022-03-31

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C07D207/38 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  A61K31/341

Abstract: Provided are compounds of Formula III that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US10654839B2

公开(公告)日：2020-05-19

申请号：US15546167

申请日：2016-01-26

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C07D207/36 ,  C07D413/06 ,  C07D237/14 ,  C07D207/38 ,  C07D307/60 ,  C07D307/66 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D307/30 ,  C07D307/58 ,  C07D405/06 ,  A61K45/06 ,  C12N7/00 ,  C07D207/456 ,  C07D317/64 ,  C07D417/06 ,  C07D471/04 ,  A61P35/02 ,  C07D209/48 ,  C07D231/08 ,  A61K31/341

Abstract: Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. Compounds of Formula (II):

公开(公告)号：US20180112190A1

公开(公告)日：2018-04-26

申请号：US15546167

申请日：2016-01-26

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C12N7/00 ,  C07D207/36 ,  C07D307/60 ,  C07D307/66 ,  C07D307/58 ,  C07D317/64 ,  C07D237/14 ,  C07D207/456 ,  C07D405/04 ,  C07D471/04 ,  C07D403/06 ,  C07D405/12 ,  C07D401/06 ,  C07D307/30 ,  C07D417/06 ,  C07D413/06

CPC classification number: C07D413/06 ,  A61K31/341 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20220220101A1

公开(公告)日：2022-07-14

申请号：US17710386

申请日：2022-03-31

Applicant: Ottawa Hospital Research Institute ,  University of Ottawa

Inventor： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC: C07D413/06 ,  C07D237/14 ,  C07D207/38 ,  C07D307/60 ,  C07D307/66 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D307/30 ,  C07D307/58 ,  C07D405/06 ,  A61K45/06 ,  A61K31/501 ,  C12N7/00 ,  C07D207/36 ,  C07D207/456 ,  C07D317/64 ,  C07D417/06 ,  C07D471/04 ,  A61P35/02 ,  C07D209/48 ,  C07D231/08

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.