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公开(公告)号：US20240360115A1
公开(公告)日：2024-10-31
申请号：US18764292
申请日：2024-07-04
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C07D413/06 , A61K31/341 , A61K31/501 , A61K45/06 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00
CPC分类号： C07D413/06 , A61K31/501 , A61K45/06 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , A61K31/341 , A61K2300/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：US20220220101A1
公开(公告)日：2022-07-14
申请号：US17710386
申请日：2022-03-31
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , A61K31/501 , C12N7/00 , C07D207/36 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：US11339146B2
公开(公告)日：2022-05-24
申请号：US16877291
申请日：2020-05-18
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： A61K31/501 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/36 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要： Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：US20180305345A1
公开(公告)日：2018-10-25
申请号：US15542480
申请日：2016-01-26
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Fabrice Le Boeuf , John C. Bell , Andrew Macklin , Jeffrey Smith
IPC分类号： C07D413/06 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D471/04 , A61P35/02
CPC分类号： C07D413/06 , A61K31/341 , A61K31/4015 , A61K31/402 , A61K2300/00 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：US10654839B2
公开(公告)日：2020-05-19
申请号：US15546167
申请日：2016-01-26
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C07D207/36 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要： Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. Compounds of Formula (II):
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公开(公告)号：US20180112190A1
公开(公告)日：2018-04-26
申请号：US15546167
申请日：2016-01-26
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C12N7/00 , C07D207/36 , C07D307/60 , C07D307/66 , C07D307/58 , C07D317/64 , C07D237/14 , C07D207/456 , C07D405/04 , C07D471/04 , C07D403/06 , C07D405/12 , C07D401/06 , C07D307/30 , C07D417/06 , C07D413/06
CPC分类号： C07D413/06 , A61K31/341 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：US20240307469A1
公开(公告)日：2024-09-19
申请号：US18680187
申请日：2024-05-31
发明人： Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
IPC分类号： A61K35/766 , A61K31/225 , A61K39/00 , A61P35/00 , C07C69/60 , C12N7/00
CPC分类号： A61K35/766 , A61K31/225 , A61P35/00 , C07C69/60 , C12N7/00 , A61K2039/585 , C12N2710/10332 , C12N2710/10351 , C12N2740/16134 , C12N2760/16134 , C12N2760/16151 , C12N2760/20232 , C12N2760/20251
摘要： Provided herein are fumaric-containing compounds, compositions comprising the same and methods for using such compounds for increasing the capacity of an interferon-sensitive virus to infect, transduce, grow or replicate in a cell or spread within one or more tissues. Also provided are methods for increasing the capacity of an interferon-sensitive virus to produce a virus-encoded transgene from a cell, by administering the compounds and compositions.
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公开(公告)号：US20200276253A1
公开(公告)日：2020-09-03
申请号：US16763013
申请日：2018-11-23
发明人： Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
IPC分类号： A61K35/766 , A61K31/225 , C12N7/00 , A61P35/00
摘要： Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
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公开(公告)号：US12076353B2
公开(公告)日：2024-09-03
申请号：US16763013
申请日：2018-11-23
发明人： Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
IPC分类号： C12N7/00 , A61K31/225 , A61K35/766 , A61P35/00 , C07C69/60 , A61K39/00
CPC分类号： A61K35/766 , A61K31/225 , A61P35/00 , C07C69/60 , C12N7/00 , A61K2039/585 , C12N2710/10332 , C12N2710/10351 , C12N2740/16134 , C12N2760/16134 , C12N2760/16151 , C12N2760/20232 , C12N2760/20251
摘要： Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
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