公开(公告)号：US20220151873A1

公开(公告)日：2022-05-19

申请号：US17528221

申请日：2021-11-17

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20 ,  B65D51/00

Abstract: A hooking and piercing device (1) for vials and tubes provided with a closing cap openable by pressure, comprising a hooking hood (2) with circumferentially distributed hooking toothed sectors (3) and an axial perforated stem (4) which extends axially and centrally out of the hooking hood (2) to be engaged by pressure inside a tube. The axial perforated stem (4) has an axially perforated appendix (6) which extends inside the hooking hood (2) and is shaped like a syringe luer. A frangible closing element (17) on the axial perforated stem (4) may be provided at the end of the axial perforated stem (4) opposite to the one with the luer-shaped appendix (6).

公开(公告)号：US20160000650A1

公开(公告)日：2016-01-07

申请号：US14790175

申请日：2015-07-02

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/14 ,  A61J1/20 ,  A61J1/10

CPC classification number: A61J1/1468 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1443 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2027 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2089 ,  A61J1/2093 ,  B65D81/3216 ,  B65D81/3266

Abstract: A package for infusion or instillation of medicinal or nutritional products into the body of a patient comprises a bag of liquid diluent equipped with at least one drain tube and a mixing tube equipped with a coupling and perforation device for a bottle of a pharmacological or nutritional substance in powder, gel or other material, provided with a perforatable cap. The package comprises a flexible airtight sterile casing, containing said bottle of the substance in powder or other and the coupling and perforation device. The bottle is housed in the casing in a coupling position with the coupling and perforation device and is manually manoeuvrable from the outside of the casing up to a perforating position of the cap of the bottle.

Abstract translation: 用于将药用或营养产品注入或滴注到患者体内的包装包括装有至少一个排液管和配备有用于药物或营养物质瓶的联接和穿孔装置的混合管的液体稀释剂袋 在粉末，凝胶或其他材料中，设置有可穿孔的帽。 该包装包括柔性密封的无菌套管，其容纳所述物质的粉末或其它物质，以及联接和穿孔装置。 瓶子与管接头和穿孔装置处于联接位置，并从壳体的外部手动操作，直到瓶盖的穿孔位置。

公开(公告)号：US20250057727A1

公开(公告)日：2025-02-20

申请号：US18725922

申请日：2022-09-26

Applicant: Paolo Gobbi Frattini s.r.l.

Inventor： Dario CASPANI ,  Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20

Abstract: A pressure compensation device (1) for an apparatus for the reconstitution, withdrawal and transfer of a drug from a vial or other vacuum container with a hermetic closure plug being pierceable by axial pressure comprises a three-dimensional compensation bag (2) with distinct flexible walls (3) and internal space (4) containing sterile air, which is interposed between a device (5) for hooking and piercing the closure plug of the vial (16) and a terminal connector (6) with an hermetic closure valve being openable by axial pressure applied with the luer (25) of a needless syringe (27) or with other extraction means and automatically hermetically reclosable upon ceasing pressure. The hooking and piercing device (5) comprises a hooking and retaining cowling (7), a piercing stem (11) with axial internal passage (49), and a sealing element (12).

公开(公告)号：US20160251620A1

公开(公告)日：2016-09-01

申请号：US15027709

申请日：2014-10-06

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: C12N5/078 ,  B01D21/26

CPC classification number: C12N5/0634 ,  B01D21/26 ,  G01N33/5002

Abstract: The present invention relates to a method for retrieving more numerous, viable and efficient stem cells from the blood of a patient. The method comprises a preliminary step of pre-treating blood cells using an oxygen-ozone mixture and a subsequent step of separating the stem cells from said pre-treated blood cells.

Abstract translation: 本发明涉及一种用于从患者的血液中检索更多的，可行且有效的干细胞的方法。 该方法包括使用氧 - 臭氧混合物预处理血液细胞的预备步骤，以及从所述预处理的血细胞中分离干细胞的后续步骤。

公开(公告)号：US20220160580A1

公开(公告)日：2022-05-26

申请号：US17531841

申请日：2021-11-22

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI ,  Dario Caspani

IPC: A61J1/14 ,  A61J1/10

Abstract: A connector (3) which is applicable to a bag (1) for containing liquid solutions for medical or nutritional use comprises a coupling part (11) for coupling to an end of a small tube (2) projecting from the bag (1) and provided with an axial hole (5) closed by a pierceable inner membrane (6). The coupling part (11) includes two coaxial tubes (12, 13) which define an annular space (14) extending axially with a constant cross-section, into which said end of the small tube (2) is forcibly insertable by axial pressure.

公开(公告)号：US20230147763A1

公开(公告)日：2023-05-11

申请号：US17983550

申请日：2022-11-09

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/2006 ,  A61J1/2037

Abstract: A preassembled component (1) for connectable element assembly for the reconstitution of fluid drugs and nutrients with active substances in powder, liquid or gel form, consists of a female connector (2) with a hermetic closing valve (8) openable by pressure and automatically hermetically reclosable upon the removal of the pressure, which is directly fastened to a coupling and piercing device (3) for vials or the like.

公开(公告)号：US20170100307A1

公开(公告)日：2017-04-13

申请号：US15287235

申请日：2016-10-06

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20 ,  A61J1/14 ,  A61J1/10

CPC classification number: A61J1/2093 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1475 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/201 ,  A61J1/2027 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2089 ,  B65D81/3266

Abstract: There is described a package for the reconstitution and administration of fluid medicinal or nutritional substances which are infused or instillable within the body of a patient, comprising a flexible casing containing a vial of a medicinal or nutritional substance in a coupling position to a coupling and perforation device inserted into a mixing tube for the connection with a bag of liquid diluent. The casing comprises a connector provided with an openable and hermetically closable cap, adapted to introduce a mixture of sterilizing gas and oxygen into said casing.

公开(公告)号：US20170056288A1

公开(公告)日：2017-03-02

申请号：US15248353

申请日：2016-08-26

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/14 ,  A61J1/20

CPC classification number: A61J1/1412 ,  A61J1/1406 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2055 ,  B01L3/50825 ,  B01L2300/044 ,  B65D51/002

Abstract: A closing plug for a sealed sterile vial containing medical or nutritional active substances, which is suitable for the sterile connection to a container of liquid diluent solution. There is also described a sterile connection system between a sealed sterile vial closed by means of a plug and a tube for drawing said active substances, for mixing them with a liquid diluent solution inside a sterile container. The plug requires an internal sterile chamber in which, upon the piercing of an outer film for sealing the plug, a compressible protection cap of a piercing tip of the tube is inserted, which abuts against a seat of the sterile chamber allowing the tip to pierce the end wall of the protection cap and then the inner membrane of the closing plug. An intermediate pierceable membrane placed on the seat of the internal chamber of the vial may be included.

Abstract translation: 用于密封的灭菌小瓶的封闭塞，其包含医疗或营养活性物质，其适用于与液体稀释剂溶液的容器的无菌连接。 还描述了在通过塞子封闭的密封的无菌小瓶和用于拉伸所述活性物质的管之间的无菌连接系统，以将它们与无菌容器内的液体稀释剂溶液混合。 塞子需要内部的无菌室，其中在穿过用于密封塞子的外部膜的穿孔时，插入管的穿刺尖端的可压缩保护帽，其抵靠无菌室的座，允许尖端刺穿 保护盖的端壁，然后是封闭塞的内膜。 可以包括放置在小瓶的内室的座上的中间可穿透膜。