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    Method and means to seal the casing-by-casing annulus at the surface for reverse circulation cement jobs
    6.
    发明申请
    Method and means to seal the casing-by-casing annulus at the surface for reverse circulation cement jobs 有权
    在表面密封套管套管环路用于反循环水泥作业的方法和方法

    公开(公告)号：US20070137870A1

    公开(公告)日：2007-06-21

    申请号：US11314044

    申请日：2005-12-20

    申请人： James Griffith ,  Caleb Carroll

    发明人： James Griffith ,  Caleb Carroll

    IPC分类号： E21B19/00

    CPC分类号： E21B33/05 ,  E21B33/14

    摘要： A method for sealing an annulus defined between an outer casing and an inner casing, the method having steps as follows: fastening a lock ring to an anchor base, wherein the lock ring comprises a threaded fastener of the lock ring to the head; positioning the lock ring and anchor base about the outer casing; fastening a limit clamp to an exterior surface of the outer casing; repositioning the lock ring and anchor base so that the anchor base is in contact with the limit clamp; fastening a head to the lock ring; providing an opening for fluid communication with the annulus through the head; positioning a plug about the inner casing and in contact with the inner casing and the head; positioning a seal fitting clamp about the inner casing and in contact with the plug; positioning a bull cap about the inner casing and in contact with the seal fitting clamp; and fastening the bull cap to the head.

    摘要翻译： 一种用于密封限定在外壳和内壳之间的环的方法，所述方法具有以下步骤：将锁环固定到锚固基座，其中所述锁环包括所述锁环的螺纹紧固件到所述头部; 将锁环和锚固基座围绕外壳定位; 将限位夹固定到所述外壳的外表面; 重新定位锁定环和锚固基座，使得锚固基座与限位夹具接触; 将头部固定在锁环上; 提供用于通过头部与环带流体连通的开口; 将塞子定位在内壳体周围并与内壳体和头部接触; 将密封配件夹具围绕内壳定位并与插头接触; 将公牛帽围绕内壳定位并与密封配件夹具接触; 并将公牛帽固定在头上。

    Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
    7.
    发明申请
    Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 审中-公开
    包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US20070010952A1

    公开(公告)日：2007-01-11

    申请号：US11471290

    申请日：2006-06-19

    申请人： David Armistead ,  Matthew Fitzgibbon ,  Mark Fleming ,  James Griffith ,  Eunice Kim ,  Joseph Kim ,  Michael Sintchak ,  John Thomson ,  Keith Wilson

    发明人： David Armistead ,  Matthew Fitzgibbon ,  Mark Fleming ,  James Griffith ,  Eunice Kim ,  Joseph Kim ,  Michael Sintchak ,  John Thomson ,  Keith Wilson

    IPC分类号： G06F19/00 ,  C07K14/705

    CPC分类号： C07K14/705 ,  C12N9/16

    摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

    摘要翻译： 本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。 本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。 这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。 此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。 本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。