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公开(公告)号：US11459385B2
公开(公告)日：2022-10-04
申请号：US16925227
申请日：2020-07-09
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20190106488A1
公开(公告)日：2019-04-11
申请号：US16133939
申请日：2018-09-18
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC: C07K16/24
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20230340106A1
公开(公告)日：2023-10-26
申请号：US17946941
申请日：2022-09-16
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC: C07K16/24
CPC classification number: C07K16/246 , C07K2317/76 , C07K2317/21 , C07K2317/51 , A61K2039/505
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20210061902A1
公开(公告)日：2021-03-04
申请号：US16925227
申请日：2020-07-09
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. RONDON , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC: C07K16/24
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US20170114130A1
公开(公告)日：2017-04-27
申请号：US15331038
申请日：2016-10-21
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
IPC: C07K16/24
CPC classification number: C07K16/246 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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Patent Agency Ranking
公开(公告)号：US12103958B2
公开(公告)日：2024-10-01
申请号：US17035327
申请日：2020-09-28
Applicant: PFIZER INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Natasha Kay Crellin , Lauren Kate Ely , Jason Robles Reyes , Chia Chi Ho , Jeffrey A. Bluestone , Eleonora Trotta , Qizhi Tang
IPC: C07K14/705 , A61K39/00 , C12N15/63 , G01N33/50 , G01N33/68
CPC classification number: C07K14/70528 , A61K39/001129 , C12N15/63 , G01N33/505 , G01N33/68 , C07K2319/30 , G01N2333/70507
Abstract: The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 polypeptide molecules.
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公开(公告)号：US10738113B2
公开(公告)日：2020-08-11
申请号：US16133939
申请日：2018-09-18
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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公开(公告)号：US10138298B2
公开(公告)日：2018-11-27
申请号：US15331038
申请日：2016-10-21
Applicant: Pfizer Inc. , The Regents of the University of California , The Board of Trustees of the Leland Stanford Junior University
Inventor： Isaac J. Rondon , Natasha Crellin , Paul Bessette , Eleonora Trotta , Jeffrey A. Bluestone , Lauren K. Ely , Kenan C. Garcia
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
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9.发明公开公开(公告)号：US20230280341A1
公开(公告)日：2023-09-07
申请号：US17860014
申请日：2022-07-07
Applicant: The Regents of the University of California
Inventor： Jeffrey A. Bluestone , Weihong Liu , Amy Putnam
IPC: G01N33/569 , A61K39/00 , C12N5/0783 , G01N33/50 , A61K35/17
CPC classification number: G01N33/56972 , A61K39/0008 , C12N5/0636 , G01N33/505 , A61K35/17 , A61K2039/515 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , A61K2035/122
Abstract: The invention provides methods of isolating CD 127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
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公开(公告)号：US09801911B2
公开(公告)日：2017-10-31
申请号：US14382537
申请日：2013-03-01
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Qizhi Tang , Jeffrey A. Bluestone
IPC: C12N5/071 , C12N5/00 , C12N5/02 , A61K35/17 , A61K31/436 , A61K31/5377 , A61K31/573 , C12N5/0783 , A61K39/00 , C12N5/0781
CPC classification number: A61K35/17 , A61K31/436 , A61K31/5377 , A61K31/573 , A61K39/001 , A61K2300/00 , C12N5/0635 , C12N5/0637 , C12N2501/04 , C12N2501/2304 , C12N2501/515 , C12N2502/1107 , C12N2502/30
Abstract: The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.
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