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公开(公告)号：US07201940B1
公开(公告)日：2007-04-10
申请号：US09880514
申请日：2001-06-12
Applicant: Pamela A. Kramer
Inventor： Pamela A. Kramer
IPC: B05D1/02
CPC classification number: A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/082 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B05B7/0006 , B05B7/203 , B05B7/205 , B05B7/224 , B05B7/226 , C23C4/12 , C23C24/04 , C23C28/00 , C23C28/028 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/3455 , C23C28/36 , Y10T428/12021 , Y10T428/12292 , Y10T428/12299 , Y10T428/13 , Y10T428/1376 , Y10T428/139
Abstract: The invention relates to devices for the treatment of heart disease and particularly to endo-arterial prostheses, which are commonly called stents. More particularly, the invention relates to methods of manufacturing and coating stents utilizing thermal spray processing (TSP). In one aspect the invention involves the use of TSP for the manufacture of fine grained tubing for subsequent use as a stent or other tubular or ring-based implant, or the manufacture of intermediate sized tubing that may then be drawn to final size tubing and for the coating of a stent. An average grain size of less than 64 microns is achieved by the invention resulting in a stent having an annular wall average thickness of about eight or more grains.
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公开(公告)号：US08562664B2
公开(公告)日：2013-10-22
申请号：US10032659
申请日：2001-10-25
Applicant: Pamela A. Kramer , John William Morris, Jr.
Inventor： Pamela A. Kramer , John William Morris, Jr.
IPC: A61F2/06
CPC classification number: A61L29/02 , A61F2/01 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61L31/022 , A61L31/14
Abstract: Medical devices are manufactured from fine grained materials, processed from of a variety of metals and alloys, such as stainless steel, cobalt-chromium and nickel-titanium alloys. A fine grained metal or alloy is formed from a specimen rapidly heated to its recrystallization temperature, and then subjected to high temperature, multi-axial deformation, for example, by heavy cross-forging or swaging. The deformed specimen may be cooled and reheated to a second recrystallization temperature. The metal or alloy in the specimen is then allowed to recrystallize, such that the grain size is controlled by quenching the specimen to room temperature. A desired medical device is then configured from the fine grained material. Decreasing the average grain size of a substrate material and increasing the number of grains across a thickness of a strut or similar component of the medical device increases the strength of the device and imparts other beneficial properties into the device.
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公开(公告)号：US07163715B1
公开(公告)日：2007-01-16
申请号：US10331838
申请日：2002-12-30
Applicant: Pamela A. Kramer
Inventor： Pamela A. Kramer
IPC: B05D1/02
CPC classification number: A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/082 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B05B7/0006 , B05B7/203 , B05B7/205 , B05B7/224 , B05B7/226 , C23C4/12 , C23C24/04 , C23C28/00 , C23C28/028 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/3455 , C23C28/36 , Y10T428/12021 , Y10T428/12292 , Y10T428/12299 , Y10T428/13 , Y10T428/1376 , Y10T428/139
Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
Abstract translation: 使用热喷涂处理和冷喷涂处理从生物相容性金属，金属合金，陶瓷和聚合物制造多孔起始材料（例如管材料，线材和基材片），其可以进一步加工成多孔医疗装置，例如支架。 喷雾方法也用于在固体生物相容性医疗装置上形成多孔涂层。 多孔基材和涂层可以用作储存器以容纳用于体内洗脱的药物或治疗剂。 喷雾形成的多孔基材和涂层可以在功能上分级，以允许药物洗脱的直接控制，而不需要额外的聚合物面漆。 当药物或试剂足够坚固以承受喷雾过程的温度和速度并且具有最小降解时，喷雾方法也用于将药物或试剂施用于多孔基质或涂层。
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公开(公告)号：US08430923B2
公开(公告)日：2013-04-30
申请号：US11736979
申请日：2007-04-18
Applicant: Stephen Pacetti , Pamela A. Kramer
Inventor： Stephen Pacetti , Pamela A. Kramer
CPC classification number: A61L31/18 , A61F2/91 , A61F2/92 , A61L31/022
Abstract: The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.
Abstract translation: 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。
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公开(公告)号：US07854958B2
公开(公告)日：2010-12-21
申请号：US12406866
申请日：2009-03-18
Applicant: Pamela A. Kramer
Inventor： Pamela A. Kramer
CPC classification number: A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/082 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B05B7/0006 , B05B7/203 , B05B7/205 , B05B7/224 , B05B7/226 , C23C4/12 , C23C24/04 , C23C28/00 , C23C28/028 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/3455 , C23C28/36 , Y10T428/12021 , Y10T428/12292 , Y10T428/12299 , Y10T428/13 , Y10T428/1376 , Y10T428/139
Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
Abstract translation: 使用热喷涂处理和冷喷涂处理从生物相容性金属，金属合金，陶瓷和聚合物制造多孔起始材料（例如管材料，线材和基材片），其可以进一步加工成多孔医疗装置，例如支架。 喷雾方法也用于在固体生物相容性医疗装置上形成多孔涂层。 多孔基材和涂层可以用作储存器以容纳用于体内洗脱的药物或治疗剂。 喷雾形成的多孔基材和涂层可以在功能上分级，以允许药物洗脱的直接控制，而不需要额外的聚合物面漆。 当药物或试剂足够坚固以承受喷雾过程的温度和速度并且具有最小降解时，喷雾方法也用于将药物或试剂施用于多孔基质或涂层。
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Patent Agency Ranking
公开(公告)号：US20130013055A1
公开(公告)日：2013-01-10
申请号：US13618602
申请日：2012-09-14
Applicant: Stephen Pacetti , Pamela A. Kramer
Inventor： Stephen Pacetti , Pamela A. Kramer
IPC: A61F2/86
CPC classification number: A61L31/18 , A61F2/91 , A61F2/92 , A61L31/022
Abstract: The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.
Abstract translation: 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。
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公开(公告)号：US20090176005A1
公开(公告)日：2009-07-09
申请号：US12406866
申请日：2009-03-18
Applicant: Pamela A. Kramer
Inventor： Pamela A. Kramer
CPC classification number: A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/082 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B05B7/0006 , B05B7/203 , B05B7/205 , B05B7/224 , B05B7/226 , C23C4/12 , C23C24/04 , C23C28/00 , C23C28/028 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/3455 , C23C28/36 , Y10T428/12021 , Y10T428/12292 , Y10T428/12299 , Y10T428/13 , Y10T428/1376 , Y10T428/139
Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
Abstract translation: 使用热喷涂处理和冷喷涂处理从生物相容性金属，金属合金，陶瓷和聚合物制造多孔起始材料（例如管材料，线材和基材片），其可以进一步加工成多孔医疗装置，例如支架。 喷雾方法也用于在固体生物相容性医疗装置上形成多孔涂层。 多孔基材和涂层可以用作储存器以容纳用于体内洗脱的药物或治疗剂。 喷雾形成的多孔基材和涂层可以在功能上分级，以允许药物洗脱的直接控制，而不需要额外的聚合物面漆。 当药物或试剂足够坚固以承受喷雾过程的温度和速度并且具有最小降解时，喷雾方法也用于将药物或试剂施用于多孔基质或涂层。
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公开(公告)号：US06725901B1
公开(公告)日：2004-04-27
申请号：US10330642
申请日：2002-12-27
Applicant: Pamela A. Kramer , James M. Carlson
Inventor： Pamela A. Kramer , James M. Carlson
IPC: B22D1700
CPC classification number: B22F3/225 , A61L31/146 , A61L31/16 , B22D17/007 , Y10S164/90 , Y10S623/901
Abstract: The invention relates to methods of manufacturing various medical devices and starting materials by utilizing the processes of high speed injection molding and slurry-based, semi-solid die casting applied to biocompatible metals or metal alloys that may have a high melting point temperature. These devices may be made fully consolidated or porous to allow the devices to act as a functional drug delivery vehicle.
Abstract translation: 本发明涉及通过利用高速注射成型法和基于浆液的半固体压铸方法制造各种医疗装置和起始材料的方法，其应用于可能具有高熔点温度的生物相容性金属或金属合金。 这些装置可以被制成完全固化或多孔的，以允许装置充当功能性药物递送载体。
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公开(公告)号：US08852264B2
公开(公告)日：2014-10-07
申请号：US13618602
申请日：2012-09-14
Applicant: Stephen Pacetti , Pamela A. Kramer
Inventor： Stephen Pacetti , Pamela A. Kramer
CPC classification number: A61L31/18 , A61F2/91 , A61F2/92 , A61L31/022
Abstract: The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.
Abstract translation: 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。
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公开(公告)号：US07514122B2
公开(公告)日：2009-04-07
申请号：US11582703
申请日：2006-10-17
Applicant: Pamela A. Kramer
Inventor： Pamela A. Kramer
IPC: B05D1/02 , B05D1/08 , B05D7/00 , B29B15/10 , C23C4/02 , B29D22/00 , B22F3/115 , B22F5/12 , A61F2/06
CPC classification number: A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/082 , A61L31/088 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B05B7/0006 , B05B7/203 , B05B7/205 , B05B7/224 , B05B7/226 , C23C4/12 , C23C24/04 , C23C28/00 , C23C28/028 , C23C28/321 , C23C28/322 , C23C28/34 , C23C28/3455 , C23C28/36 , Y10T428/12021 , Y10T428/12292 , Y10T428/12299 , Y10T428/13 , Y10T428/1376 , Y10T428/139
Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
Abstract translation: 使用热喷涂处理和冷喷涂处理从生物相容性金属，金属合金，陶瓷和聚合物制造多孔起始材料（例如管材，线材和基材片），其可以进一步加工成多孔医疗装置，例如支架。 喷雾方法也用于在固体生物相容性医疗装置上形成多孔涂层。 多孔基材和涂层可以用作储存器以容纳用于体内洗脱的药物或治疗剂。 喷雾形成的多孔基材和涂层可以在功能上分级，以允许药物洗脱的直接控制，而不需要额外的聚合物面漆。 当药物或试剂足够坚固以承受喷雾过程的温度和速度并且具有最小降解时，喷雾方法也用于将药物或试剂施用于多孔基质或涂层。
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