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公开(公告)号：US20080242878A1
公开(公告)日：2008-10-02
申请号：US11886253
申请日：2006-03-13
IPC分类号： C07D305/08
CPC分类号： C07D305/14
摘要： The invention discloses novel secotaxane derivatives of general formula 1, having cytotoxic activity, which can be administered through the injective or oral route, for the therapy of tumors.
摘要翻译： 本发明公开了具有通过注射或口服途径施用的具有细胞毒活性的通式1的新型二硫代衍生物用于治疗肿瘤。
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2.发明授权Antitumoral agents with a benzophenanthridine structure and formulations containing them 有权具有苯并菲啶结构的抗肿瘤剂和含有它们的制剂公开(公告)号：US08337903B2
公开(公告)日：2012-12-25
申请号：US12918453
申请日：2009-02-16
IPC分类号： A61K35/12
CPC分类号： A61K31/473
摘要： The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.
摘要翻译： 公开了苯并菲啶生物碱及其盐在制备用于治疗肿瘤的药物中的用途。
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公开(公告)号：US08076351B2
公开(公告)日：2011-12-13
申请号：US12374799
申请日：2007-07-12
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： Y02P20/55
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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4.发明申请COMPOSITIONS FOR THE TREATMENT OF VAGINAL INFECTIONS WITH CHRONIC INFLAMMATION 审中-公开用于治疗伴有慢性淋巴细胞炎的阴道感染的组合物公开(公告)号：US20110104313A1
公开(公告)日：2011-05-05
申请号：US12988897
申请日：2009-04-06
申请人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
发明人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
IPC分类号： A61K36/28 , A61K36/758 , A61K36/66 , A61P29/00 , A61P31/00
CPC分类号： A61K36/28 , A61K31/343 , A61K31/473 , A61K36/758 , A61K2300/00
摘要： The present invention relates to compositions comprising benzofuran compounds and benzophenanthridine alkaloids, which possess anti-inflammatory, antibacterial and antifungal activity useful in the treatment of vaginal infections and the resulting inflammatory states.
摘要翻译： 本发明涉及包含苯并呋喃化合物和苯并菲啶生物碱的组合物，其具有用于治疗阴道感染和所得炎症状态的抗炎，抗菌和抗真菌活性。
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5.发明申请公开(公告)号：US20110091392A1
公开(公告)日：2011-04-21
申请号：US12988870
申请日：2009-04-06
申请人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
发明人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
IPC分类号： A61K9/68 , A61K31/4355 , A61K8/49 , A61P1/02
CPC分类号： A61K45/06 , A61K31/343 , A61K31/473 , A61K2300/00
摘要： The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
摘要翻译： 本发明涉及可用于治疗和预防口腔感染的苯并菲啶生物碱，苯并呋喃化合物和儿茶素多酚的组合物。
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6.发明申请FORMULATIONS FOR THE TREATMENT OF MUCOSITIS INDUCED BY ANTITUMOR OR IMMUNOSUPPRESSIVE THERAPY 有权治疗由抗肿瘤药物或免疫抑制治疗诱发的肌瘤的制剂公开(公告)号：US20100284945A1
公开(公告)日：2010-11-11
申请号：US12812065
申请日：2009-01-08
申请人： Ezio Bombardelli , Gabriele Fontana
发明人： Ezio Bombardelli , Gabriele Fontana
IPC分类号： A61K31/4355 , A61K9/68 , C07D491/22 , A61P1/04 , A61P29/00 , A61P15/02
CPC分类号： B60S3/063
摘要： Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.
摘要翻译： 含有血根碱或白藜芦醇或其盐的制剂或含有它们的提取物与适合的载体和/或赋形剂的混合物用于治疗和/或预防粘膜炎。
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公开(公告)号：US07683163B2
公开(公告)日：2010-03-23
申请号：US10559462
申请日：2004-05-26
申请人： Ezio Bombardelli , Gabriele Fontana
发明人： Ezio Bombardelli , Gabriele Fontana
CPC分类号： C07H15/248
摘要： The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
摘要翻译： 本发明涉及秋水仙素衍生物，特别涉及其中X为氧或硫的通式（I）的3-去甲基和3-脱甲基硫代秋水仙碱，其制备方法和含有它们的药物组合物。 式（I）化合物具有肌肉松弛，抗炎和抗痛风活性。
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公开(公告)号：US20080242864A1
公开(公告)日：2008-10-02
申请号：US10593651
申请日：2005-03-02
申请人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
发明人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
IPC分类号： C07D459/00
CPC分类号： C07D459/00
摘要： The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
摘要翻译： 本发明涉及从游离酸内酯（II）经由中间体11-O-去甲基存在酸内酯（III）合成脱苯西坦（Ia）的有效方法。
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9.发明申请SEMISYNTHESIS PROCESS FOR THE PREPARATION OF 10 DEACETYL-N-DEBENZOYL-PACLITAXEL 有权用于制备10种脱乙酰基-N-苯甲酰基 - 紫杉醇的SEMISYNTHESIS方法公开(公告)号：US20080200700A1
公开(公告)日：2008-08-21
申请号：US12104715
申请日：2008-04-17
IPC分类号： C07D305/14
CPC分类号： C07D413/12 , C07D305/14
摘要： The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel (I) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof.The invention also discloses a process for the preparation of Docetaxel starting from said compound of formula (I).
摘要翻译： 本发明涉及一种制备10-脱乙酰-N-脱苯甲酰 - 紫杉醇（I）的方法，该合成物可用于制备具有抗肿瘤活性的紫杉烷类和其制备中间体。 本发明还公开了从所述式（I）化合物开始制备多西他赛的方法。
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10.发明授权N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them 有权N-脱乙酰硫代秋水仙碱衍生物，其用途和含有它们的药物制剂公开(公告)号：US07399788B2
公开(公告)日：2008-07-15
申请号：US10588012
申请日：2005-02-01
申请人： Ezio Bombardelli , Gabriele Fontana
发明人： Ezio Bombardelli , Gabriele Fontana
IPC分类号： A01N37/18 , A61K31/16 , C07C273/00 , C07C275/00 , C07C381/00 , C07C243/00 , C07C223/00 , C07C235/00 , C07C233/00 , C07C237/00 , C07C321/00
CPC分类号： C07D213/82 , C07C323/30 , C07C323/41 , C07C323/44 , C07C2603/34
摘要： Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —COHN—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula (I) have antiproliferative, antinflammatory, antiarthritic and antiviral activity.
摘要翻译： 公开了一系列式（I）的N-脱乙酰基秋水仙碱衍生物，其中：连接体是二价直链或支链C 1 -C 8烷基残基，C 基团是-CO-基团。 式（I）化合物具有抗增殖，抗炎，抗关节炎和抗病毒活性。
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