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1.发明授权MRI compatible vascular occlusive devices and related methods of treatment and methods of monitoring implanted devices 失效MRI兼容血管闭塞装置及相关治疗方法及植入装置监测方法公开(公告)号：US08328862B2
公开(公告)日：2012-12-11
申请号：US12088207
申请日：2006-10-04
Applicant: Parag V. Karmarkar , Aravind Arepally
Inventor： Parag V. Karmarkar , Aravind Arepally
IPC: A61F2/06
CPC classification number: A61B5/055 , A61B5/4836 , A61B5/4839 , A61B17/12022 , A61B17/12145 , A61B2090/3954
Abstract: Implantable aneurysm-sac treatment devices include an implantable coil body configured and sized to reside in a sac of an aneurysm. The body has an inductance and capacitance. The capacitance is selected so that the coil resonates at a Larmor frequency of a predefined magnetic field strength.
Abstract translation: 可植入动脉瘤囊治疗装置包括被配置和定尺寸为位于动脉瘤囊中的可植入线圈体。 身体有电感和电容。 选择电容使得线圈以预定义的磁场强度的拉莫尔频率进行谐振。
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2.发明申请MRI Compatible Vascular Occlusive Devices and Related Methods of Treatment and Methods of Monitoring Implanted Devices 失效MRI兼容的血管闭塞装置及其相关治疗方法和监测植入装置的方法公开(公告)号：US20090216109A1
公开(公告)日：2009-08-27
申请号：US12088207
申请日：2006-10-04
Applicant: Parag V. Karmarkar , Aravind Arepally
Inventor： Parag V. Karmarkar , Aravind Arepally
CPC classification number: A61B5/055 , A61B5/4836 , A61B5/4839 , A61B17/12022 , A61B17/12145 , A61B2090/3954
Abstract: Implantable aneurysm-sac treatment devices include an implantable coil body configured and sized to reside in a sac of an aneurysm. The body has an inductance and capacitance. The capacitance is selected so that the coil resonates at a Larmor frequency of a predefined magnetic field strength.
Abstract translation: 可植入动脉瘤囊治疗装置包括被配置和定尺寸为位于动脉瘤囊中的可植入线圈体。 身体有电感和电容。 选择电容使得线圈以预定的磁场强度的拉莫尔频率谐振。
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3.发明申请TRANSCAVAL MESENTERIC VENOUS ANASTOMOSIS AND ACCESS SYSTEM 审中-公开TRANSCAVAL MESENTERIC VENOUS ANASTOMOSIS和ACCESS SYSTEM公开(公告)号：US20100106171A1
公开(公告)日：2010-04-29
申请号：US11919870
申请日：2006-05-05
Applicant: Aravind Arepally , Parag V. Karmarkar , Qian Di , Ergin Atalar
Inventor： Aravind Arepally , Parag V. Karmarkar , Qian Di , Ergin Atalar
IPC: A61B17/00
CPC classification number: A61B17/11 , A61B17/3498 , A61B2017/00252 , A61B2017/1103 , A61B2017/1107 , A61B2017/1139 , A61B2017/22077 , A61B2090/3954
Abstract: Disclosed is a system for creating an anastomosis between the inferior vena cava (IVC) and the mesenteric portal vein. The system includes an anastomosis device and a catheter. The anastomosis device brings the IVC and the portal vein into apposition. The resulting anastomosis enables treatment for portal hypertension as well as provides repeated and easy access to the portal system for direct delivery of therapeutic agents to portal organs. The anastomosis device has a proximal flange part, a distal flange part, a flow lumen between them. The proximal and distal flange parts include a plurality of radial struts. A valve part is disposed on one or both of the proximal and distal flange parts. The anastomosis device is made of a memory shape material. The catheter contains a collapsed anastomosis device for insertion and has one or more RF antennas to make the catheter visible under MRI guidance.
Abstract translation: 公开了一种用于创建下腔静脉（IVC）与肠系膜门静脉吻合的系统。 该系统包括吻合装置和导管。 吻合装置将IVC和门静脉并入。 所得到的吻合可以治疗门静脉高压，并且可以重复和容易地进入门静脉系统，以将治疗剂直接递送到门静脉器官。 吻合装置具有近侧凸缘部分，远侧凸缘部分，它们之间的流动腔。 近侧和远侧凸缘部分包括多个径向支柱。 阀部分设置在近侧和远端凸缘部分中的一个或两个上。 吻合装置由记忆形状材料制成。 导管包含用于插入的折叠吻合装置，并且具有一个或多个RF天线以使导管在MRI引导下可见。
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公开(公告)号：US09539081B2
公开(公告)日：2017-01-10
申请号：US13306105
申请日：2011-11-29
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
CPC classification number: A61F2/013 , A61B17/00491 , A61B17/12186 , A61B2017/22082 , A61F2/01 , A61F2/2412 , A61F2/2436 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004
Abstract: An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.
Abstract translation: 在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。 该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。 第一个细丝具有径向扩张阀的弹簧偏压。 向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。 导管的内腔与阀的中心连通。 该装置用于提供其中将治疗剂输注到器官中的治疗。
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公开(公告)号：US08500775B2
公开(公告)日：2013-08-06
申请号：US12829565
申请日：2010-07-02
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
IPC: A61M29/00
CPC classification number: A61F2/013 , A61B17/12172 , A61B17/12186 , A61F2002/018 , A61F2230/0006 , A61F2230/008
Abstract: An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
Abstract translation: 提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的反流（反流或逆流）。 还提供了使用该装置的方法。
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Patent Agency Ranking
6.发明申请Microvalve Protection Device and Method of Use for Protection Against Embolization Agent Reflux 有权微阀保护装置及其防止栓塞剂回流的使用方法公开(公告)号：US20120089102A1
公开(公告)日：2012-04-12
申请号：US13280608
申请日：2011-10-25
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC: A61M25/00
CPC classification number: A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
Abstract: An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve.
Abstract translation: 在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。 该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。 第一个细丝具有径向扩张阀的弹簧偏压。 向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。 导管的内腔与阀的中心连通。
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公开(公告)号：US20110130657A1
公开(公告)日：2011-06-02
申请号：US12829565
申请日：2010-07-02
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
CPC classification number: A61F2/013 , A61B17/12172 , A61B17/12186 , A61F2002/018 , A61F2230/0006 , A61F2230/008
Abstract: An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
Abstract translation: 提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的回流（反流或逆流）。 还提供了使用该装置的方法。
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8.发明授权Microvalve protection device and method of use for protection against embolization agent reflux 有权微阀保护装置及其用于防止栓塞剂回流的方法公开(公告)号：US08696698B2
公开(公告)日：2014-04-15
申请号：US12957533
申请日：2010-12-01
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC: A61M29/00
CPC classification number: A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
Abstract: An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
Abstract translation: 提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的反流（反流或逆流）。 还提供了使用该装置的方法。
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9.发明申请Microvalve Protection Device and Method of Use for Protection Against Embolization Agent Reflux 有权微阀保护装置及其防止栓塞剂回流的使用方法公开(公告)号：US20110137399A1
公开(公告)日：2011-06-09
申请号：US12957533
申请日：2010-12-01
Applicant: James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
Inventor： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
CPC classification number: A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
Abstract: An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
Abstract translation: 提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的反流（反流或逆流）。 还提供了使用该装置的方法。
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公开(公告)号：US20110020239A1
公开(公告)日：2011-01-27
申请号：US12600445
申请日：2008-05-14
Applicant: Jeff Bulte , Bradley Powers Barnett , Aravind Arepally
Inventor： Jeff Bulte , Bradley Powers Barnett , Aravind Arepally
CPC classification number: A61K49/0002 , A61K49/0409 , A61K49/222
Abstract: The instant invention provides methods for the in vivo imaging of cells using one or more imaging modalities.
Abstract translation: 本发明提供使用一种或多种成像模态进行细胞体内成像的方法。
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