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公开(公告)号：US20140030705A1
公开(公告)日：2014-01-30
申请号：US13880365
申请日：2011-10-20
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6827 , C12Q2565/629 , C12Q2563/185 , C12Q2563/107 , C12Q2537/1376 , C12Q2521/531
摘要： Provided are methods and systems for assessing the presence and extent of damage on a polynucleotide. The methods include incorporating a label at the site of the damage and imaging the label to determine the presence and extent of the damage. The systems include devices capable of performing damage assessment on single molecules.
摘要翻译： 提供了用于评估多核苷酸损伤的存在和程度的方法和系统。 这些方法包括在损伤部位加入标签并对标签进行成像，以确定损伤的存在和程度。 该系统包括能够对单个分子进行损伤评估的装置。
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2.发明授权Integrated analysis devices and related fabrication methods and analysis techniques 有权综合分析装置及相关制造方法和分析技术公开(公告)号：US09533879B2
公开(公告)日：2017-01-03
申请号：US12996410
申请日：2009-06-05
申请人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
发明人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
CPC分类号： B81C1/00119 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0442 , B01L2400/0487 , B01L2400/086 , B81B2201/058 , B81C2201/019 , G01N2021/0346 , G01N2021/6439 , Y10T29/4981
摘要： Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
摘要翻译： 提供了具有宏观尺寸和纳米级尺寸特征的集成分析装置，以及具有降低的背景信号并且减少设置在装置内的荧光团的淬灭的装置。 还提供了制造这些装置和使用这些装置的相关方法。
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3.发明申请INTEGRATED ANALYSIS DEVICES AND RELATED FABRICATION METHODS AND ANALYSIS TECHNIQUES 有权综合分析设备及相关制造方法与分析技术公开(公告)号：US20110296903A1
公开(公告)日：2011-12-08
申请号：US12996410
申请日：2009-06-05
申请人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
发明人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
CPC分类号： B81C1/00119 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0442 , B01L2400/0487 , B01L2400/086 , B81B2201/058 , B81C2201/019 , G01N2021/0346 , G01N2021/6439 , Y10T29/4981
摘要： Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
摘要翻译： 提供了具有宏观尺寸和纳米级尺寸特征的集成分析装置，以及具有降低的背景信号并且减少设置在装置内的荧光团的淬灭的装置。 还提供了制造这些装置和使用这些装置的相关方法。
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公开(公告)号：US06787030B2
公开(公告)日：2004-09-07
申请号：US10602342
申请日：2003-06-23
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also-be monitored to detect the presence of separated components in the equate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译： 本发明包括分析组分混合物中的一种或多种分子组分的方法。 在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。 来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。 在色谱分离期间，也可以监测柱洗脱液以检测等分物中分离的组分的存在。 然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。 在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。
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公开(公告)号：US06582597B2
公开(公告)日：2003-06-24
申请号：US09885292
申请日：2001-06-19
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also be monitored to detect the presence of separated components in the eluate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译： 本发明包括分析组分混合物中的一种或多种分子组分的方法。 在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。 来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。 在色谱分离期间，还可以监测柱洗脱液以检测洗脱液中分离的组分的存在。 然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。 在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。
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公开(公告)号：US06248239B1
公开(公告)日：2001-06-19
申请号：US08887350
申请日：1997-07-02
IPC分类号： B01D1508
CPC分类号： G01N30/82 , G01N2030/8411 , Y10T436/2575
摘要： The present invention includes a method of analyzing one or more molecular components in a mixture of components. In the method, a mixture of molecular components, i.e., an analyte mixture, is separated on a capillary liquid chromatography column. The component-containing eluate from the column is deposited as a series of discrete, defined-volume microdrops, along a region of an adsorbent collection layer. During the chromatographic separation, the column eluate may also be monitored to detect the presence of separated components in the eluate. The one or more components deposited in the collection layer are then analyzed by selected analytical techniques. In related aspect, the invention includes a method of collecting one or more molecular components derived from a mixture of components, a blotter apparatus useful in the above method, and a system for analyzing one or more molecular components in a mixture of components.
摘要翻译： 本发明包括分析组分混合物中的一种或多种分子组分的方法。 在该方法中，在毛细管液相色谱柱上分离分子组分的混合物，即分析物混合物。 来自柱的含组分的洗脱液沿着吸附剂收集层的区域沉积为一系列离散的限定体积的微滴。 在色谱分离期间，还可以监测柱洗脱液以检测洗脱液中分离的组分的存在。 然后通过选择的分析技术分析沉积在收集层中的一种或多种组分。 在相关方面，本发明包括收集一种或多种衍生自组分混合物的分子组分的方法，可用于上述方法的吸墨装置和用于分析组分混合物中的一种或多种分子组分的系统。
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公开(公告)号：US20150377878A1
公开(公告)日：2015-12-31
申请号：US14851883
申请日：2015-09-11
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B82Y15/00 , G01N21/645 , G01N21/6489 , G01N33/54313 , G01N33/588 , G01N2021/6441 , G01N2021/6482 , G01N2333/4712
摘要： One aspect of the invention provides a device for detecting an analyte in a sample. The device includes: a sample loading region, an imaging window, a well, and an absorbent pad. The sample loading region is in fluid communication with the well. The well is in fluid communication with the absorbent pad, such that when a fluid sample comprising solid support structures and a liquid carrier are applied to the sample loading region, the fluid sample travels to the well and at least part of the liquid carrier is absorbed into the absorbent pad.
摘要翻译： 本发明的一个方面提供一种用于检测样品中的分析物的装置。 该装置包括：样品加载区域，成像窗口，井和吸收垫。 样品装载区域与井流体连通。 井与吸收垫流体连通，使得当将包含固体支撑结构和液体载体的流体样品施加到样品加载区域时，流体样品移动到井中，并且至少部分液体载体被吸收 进入吸收垫。
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公开(公告)号：US10031137B2
公开(公告)日：2018-07-24
申请号：US14851883
申请日：2015-09-11
IPC分类号： G01N33/543 , G01N33/58 , B82Y15/00 , B01L3/00 , G01N21/64
摘要： One aspect of the invention provides a device for detecting an analyte in a sample. The device includes: a sample loading region, an imaging window, a well, and an absorbent pad. The sample loading region is in fluid communication with the well. The well is in fluid communication with the absorbent pad, such that when a fluid sample comprising solid support structures and a liquid carrier are applied to the sample loading region, the fluid sample travels to the well and at least part of the liquid carrier is absorbed into the absorbent pad.
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