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1.发明授权Integrated analysis devices and related fabrication methods and analysis techniques 有权综合分析装置及相关制造方法和分析技术公开(公告)号：US09533879B2
公开(公告)日：2017-01-03
申请号：US12996410
申请日：2009-06-05
申请人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
发明人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
CPC分类号： B81C1/00119 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0442 , B01L2400/0487 , B01L2400/086 , B81B2201/058 , B81C2201/019 , G01N2021/0346 , G01N2021/6439 , Y10T29/4981
摘要： Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
摘要翻译： 提供了具有宏观尺寸和纳米级尺寸特征的集成分析装置，以及具有降低的背景信号并且减少设置在装置内的荧光团的淬灭的装置。 还提供了制造这些装置和使用这些装置的相关方法。
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2.发明申请INTEGRATED ANALYSIS DEVICES AND RELATED FABRICATION METHODS AND ANALYSIS TECHNIQUES 有权综合分析设备及相关制造方法与分析技术公开(公告)号：US20110296903A1
公开(公告)日：2011-12-08
申请号：US12996410
申请日：2009-06-05
申请人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
发明人： Han Cao , Michael D. Austin , Parikshit A. Deshpande , Mark Kunkel , Alexey Y. Sharonov , Michael Kochersperger
CPC分类号： B81C1/00119 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0442 , B01L2400/0487 , B01L2400/086 , B81B2201/058 , B81C2201/019 , G01N2021/0346 , G01N2021/6439 , Y10T29/4981
摘要： Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
摘要翻译： 提供了具有宏观尺寸和纳米级尺寸特征的集成分析装置，以及具有降低的背景信号并且减少设置在装置内的荧光团的淬灭的装置。 还提供了制造这些装置和使用这些装置的相关方法。
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公开(公告)号：US20110171634A1
公开(公告)日：2011-07-14
申请号：US13001697
申请日：2009-06-30
申请人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
发明人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
摘要翻译： 提供单分子基因组分析的方法和装置。 在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。 这些方法在例如确定个体之间的结构变化和拷贝数变化方面是有用的。
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公开(公告)号：US08628919B2
公开(公告)日：2014-01-14
申请号：US13001697
申请日：2009-06-30
申请人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
发明人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
摘要翻译： 提供单分子基因组分析的方法和装置。 在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。 这些方法在例如确定个体之间的结构变化和拷贝数变化方面是有用的。
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公开(公告)号：US20080242556A1
公开(公告)日：2008-10-02
申请号：US12057987
申请日：2008-03-28
CPC分类号： C12Q1/6874 , B01L3/50273 , B01L3/502761 , B01L2200/0663 , B01L2200/0668 , B01L2200/12 , B01L2300/041 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/089 , B01L2300/0896 , B01L2300/161 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , C12Q1/6876 , C12Q2563/107 , C12Q2600/172 , G01N21/6428 , G01N21/645 , G01N33/582
摘要： Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
摘要翻译： 公开了分析诸如大基因组DNA分子之间的大分子或生物标记的物理尺寸等特征的方法以及以大规模并行方式进行这种高通量分析的装置。 还公开了制造这种装置的方法。
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公开(公告)号：US08722327B2
公开(公告)日：2014-05-13
申请号：US12057987
申请日：2008-03-28
CPC分类号： C12Q1/6874 , B01L3/50273 , B01L3/502761 , B01L2200/0663 , B01L2200/0668 , B01L2200/12 , B01L2300/041 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/089 , B01L2300/0896 , B01L2300/161 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , C12Q1/6876 , C12Q2563/107 , C12Q2600/172 , G01N21/6428 , G01N21/645 , G01N33/582
摘要： Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
摘要翻译： 公开了分析诸如大基因组DNA分子之间的大分子或生物标记的物理尺寸等特征的方法以及以大规模并行方式进行这种高通量分析的装置。 还公开了制造这种装置的方法。
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7.发明授权Nanonozzle device arrays: their preparation and use for macromolecular analysis 有权Nanonozzle器件阵列：它们的制备和用于大分子分析公开(公告)号：US09061901B2
公开(公告)日：2015-06-23
申请号：US12374141
申请日：2007-07-19
IPC分类号： C12M1/34 , C12Q1/68 , G01N15/06 , G01N21/00 , C07H21/02 , B82Y30/00 , B01L3/00 , G01N33/487 , G01N35/10
CPC分类号： B82Y30/00 , B01L3/502761 , B01L2200/0663 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0822 , B01L2300/0896 , B01L2400/0415 , B01L2400/0487 , C12Q1/6869 , G01N27/447 , G01N33/48721 , G01N2035/1039 , Y10T436/143333 , Y10T436/2575 , C12Q2565/631
摘要： Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
摘要翻译： 公开了适用于分析大分子结构（包括DNA测序）的约束纳米通道器件。 还公开了制造这种装置和使用这种装置分析大分子的方法。
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8.发明申请NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS 有权纳米器件阵列：其制备和用于大分子分析公开(公告)号：US20090305273A1
公开(公告)日：2009-12-10
申请号：US12374141
申请日：2007-07-19
CPC分类号： B82Y30/00 , B01L3/502761 , B01L2200/0663 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0822 , B01L2300/0896 , B01L2400/0415 , B01L2400/0487 , C12Q1/6869 , G01N27/447 , G01N33/48721 , G01N2035/1039 , Y10T436/143333 , Y10T436/2575 , C12Q2565/631
摘要： Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.
摘要翻译： 公开了适用于分析大分子结构（包括DNA测序）的约束纳米通道装置。 还公开了制造这种装置并用于使用这种装置分析大分子的方法。
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公开(公告)号：US20140030705A1
公开(公告)日：2014-01-30
申请号：US13880365
申请日：2011-10-20
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6827 , C12Q2565/629 , C12Q2563/185 , C12Q2563/107 , C12Q2537/1376 , C12Q2521/531
摘要： Provided are methods and systems for assessing the presence and extent of damage on a polynucleotide. The methods include incorporating a label at the site of the damage and imaging the label to determine the presence and extent of the damage. The systems include devices capable of performing damage assessment on single molecules.
摘要翻译： 提供了用于评估多核苷酸损伤的存在和程度的方法和系统。 这些方法包括在损伤部位加入标签并对标签进行成像，以确定损伤的存在和程度。 该系统包括能够对单个分子进行损伤评估的装置。
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公开(公告)号：US09181578B2
公开(公告)日：2015-11-10
申请号：US13129634
申请日：2009-11-18
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/68 , C12Q1/6806 , C12Q1/6869 , C12Q2565/133 , C12Q2565/1025 , C12Q2521/301 , C12Q2563/107 , C12Q2535/101
摘要： The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
摘要翻译： 本发明提供获得关于生物聚合物样品的结构信息的方法。 所述方法包括在一些情况下标记生物聚合物（例如DNA或RNA）的部分线性化生物聚合物，并确定标签之间的距离。 然后，用户可以比较不同样品的标记间距离，以定性比较不同的样品，并测定给定的样品，用于在标签侧翼的区域中添加或缺失核苷酸。 该方法还允许对生物聚合物进行测序。
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