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    Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus
    4.
    发明授权
    Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus 有权
    寡核苷酸，其用途，用于诊断甲型流感病毒H5和N1基因存在的检测方法和试剂盒

    公开(公告)号：US08168387B2

    公开(公告)日：2012-05-01

    申请号：US12084704

    申请日：2006-11-23

    申请人： Aurélie Lefeuvre ,  Jean-Noel Telles ,  Guy Vernet

    发明人： Aurélie Lefeuvre ,  Jean-Noel Telles ,  Guy Vernet

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/701

    摘要： The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides and comprising at least one fragment of 10 consecutive nucleotides derived from the following sequences: SEQ ID No. 1:TGTATGTTGTGGAATGGCA, SEQ ID No. 2:GCCGAATGATGCCATCAA, SEQ ID No. 3:CGTGGATTGTCTCCGAAA, and SEQ ID No. 4:GGAATGCTCCTGTTATCCTGA or the sequence complementary thereto. The invention also relates to oligonucleotides for detecting amplicons, to the use of all these sequences, and to a method for detecting and a kit for diagnosing the presence of the H5 and N1 genes of the Influenza A virus.The invention is particularly applicable in the field of diagnosis.

    摘要翻译： 本发明涉及用于扩增分别位于甲型流感病毒基因组的H5和N1基因中的两个靶序列的双重寡核苷酸，所述寡核苷酸的长度范围在10至50个核苷酸之间并且至少包含 衍生自以下序列的10个连续核苷酸的一个片段：SEQ ID No.1：TGTATGTTGTGGAATGGCA，SEQ ID No.2：GCCGAATGATGCCATCAA，SEQ ID No.3：CGTGGATTGTCTCCGAAA和SEQ ID No.4：GGAATGCTCCTGTTATCCTGA或其互补序列。 本发明还涉及用于检测扩增子的寡核苷酸，所有这些序列的使用以及用于检测的方法和用于诊断甲型流感病毒的H5和N1基因的存在的试剂盒。 本发明特别适用于诊断领域。

    Oligonucleotides, Use Thereof, Detecting Method and Kit for Diagnosing the Presence of H5 and N1 Genes of the Influenza a Virus
    7.
    发明申请
    Oligonucleotides, Use Thereof, Detecting Method and Kit for Diagnosing the Presence of H5 and N1 Genes of the Influenza a Virus 有权
    寡核苷酸，其用途，用于诊断流感病毒H5和N1基因存在的检测方法和试剂盒

    公开(公告)号：US20090305243A1

    公开(公告)日：2009-12-10

    申请号：US12084704

    申请日：2006-11-23

    申请人： Aurélie Lefeuvre ,  Jean-Noel Telles ,  Guy Vernet

    发明人： Aurélie Lefeuvre ,  Jean-Noel Telles ,  Guy Vernet

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/701

    摘要： The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides and comprising at least one fragment of 10 consecutive nucleotides derived from the following sequences: SEQ ID No. 1:TGTATGTTGTGGAATGGCA, SEQ ID No. 2:GCCGAATGATGCCATCAA, SEQ ID No. 3:CGTGGATTGTCTCCGAAA, and SEQ ID No. 4:GGAATGCTCCTGTTATCCTGA or the sequence complementary thereto. The invention also relates to oligonucleotides for detecting amplicons, to the use of all these sequences, and to a method for detecting and a kit for diagnosing the presence of the H5 and N1 genes of the Influenza A virus.The invention is particularly applicable in the field of diagnosis.

    摘要翻译： 本发明涉及用于扩增分别位于甲型流感病毒基因组的H5和N1基因中的两个靶序列的双重寡核苷酸，所述寡核苷酸的长度范围在10至50个核苷酸之间并且至少包含 衍生自以下序列的10个连续核苷酸的一个片段：SEQ ID No.1：TGTATGTTGTGGAATGGCA，SEQ ID No.2：GCCGAATGATGCCATCAA，SEQ ID No.3：CGTGGATTGTCTCCGAAA和SEQ ID No.4：GGAATGCTCCTGTTATCCTGA或其互补序列。 本发明还涉及用于检测扩增子的寡核苷酸，所有这些序列的使用以及用于检测的方法和用于诊断甲型流感病毒的H5和N1基因的存在的试剂盒。 本发明特别适用于诊断领域。

    Construction of a Comparative Database and Identification of Virulence Factors Comparison of Polymorphic Regions in Clinical Isolates of Infectious Organisms
    8.
    发明申请
    Construction of a Comparative Database and Identification of Virulence Factors Comparison of Polymorphic Regions in Clinical Isolates of Infectious Organisms 审中-公开
    构建比较数据库和确定感染生物临床分离株中多态性区域的毒力因子比较

    公开(公告)号：US20080085284A1

    公开(公告)日：2008-04-10

    申请号：US11632108

    申请日：2007-04-09

    申请人： Villoo Patell ,  K.R. Rajyashri ,  Marc Rodrigue ,  Guy Vernet

    发明人： Villoo Patell ,  K.R. Rajyashri ,  Marc Rodrigue ,  Guy Vernet

    IPC分类号： A61K31/70 ,  A61K39/00 ,  A61P43/00 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C12Q1/689 ,  C12Q2600/156

    摘要： The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence' and/or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of M. tuberculosis strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the Mycobacterium tuberculosis, the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.

    摘要翻译： 本发明涉及新的核苷酸序列，用于诊断，鉴定菌株，分型和赋予其潜在的毒力程度，感染性和/或所有感染性疾病特别是结核病的潜伏期的方向。 本发明还包括通过对不同临床分离株/感染生物菌株的序列的比较基因组分析来鉴定和选择与感染性疾病相关的多态性和/或感染性疾病更特别地在结核病中的方法。 多态性区域也可以作为潜在的药物靶点和疫苗靶点。 更具体地说，本发明还涉及鉴定要包括在诊断DNA芯片中的结核分枝杆菌菌株和其他感染性生物体的毒力因子，其允许鉴定菌株，分型并最终赋予其潜在的毒力程度。 虽然已经具体参考结核分枝杆菌中的多态性区域来说明了本发明，但是本发明不被理解为并且被解释为限于结核病，而是适用于所有感染性疾病。