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22 条记录 (耗时 0.027 秒)

    Method of sterilization of polymeric microparticles
    2.
    发明申请
    Method of sterilization of polymeric microparticles 审中-公开
    聚合物微粒灭菌方法

    公开(公告)号：US20050003007A1

    公开(公告)日：2005-01-06

    申请号：US10614408

    申请日：2003-07-02

    申请人： Michele Boix ,  Christian Sarrazin ,  Patrick Hughes ,  Marina Do ,  Isabelle Maroteaux

    发明人： Michele Boix ,  Christian Sarrazin ,  Patrick Hughes ,  Marina Do ,  Isabelle Maroteaux

    IPC分类号： A61K9/16 ,  A61K31/455 ,  A61K41/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/12 ,  A61K9/14

    CPC分类号： A61L2/087 ,  A61K9/1647 ,  A61K31/455 ,  A61K41/0019 ,  A61L2/081 ,  A61L2/10 ,  A61L2/12

    摘要： This invention relates to the sterilization of polymeric material by irradiation for use in a body of a mammal. We have surprisingly discovered that the sterilization of polymeric materials for use in a mammal by irradiation is improved by reducing the temperature at which the irradiation is carried out. One aspect of this invention relates to a sterilized polymeric material for use in a body of a mammal wherein said polymeric material is sterilized by irradiation at a reduced temperature Another aspect of this invention relates to methods of sustained delivery of a therapeutically active agent to a mammal by using a polymeric material that has been sterilized at a reduced temperature by irradiation.

    摘要翻译： 本发明涉及通过照射用于哺乳动物体内的聚合材料的灭菌。 我们惊奇地发现，通过降低进行照射的温度来改善通过照射对哺乳动物使用的聚合材料的灭菌。 本发明的一个方面涉及用于哺乳动物身体的灭菌聚合物材料，其中所述聚合物材料通过在降低的温度下照射而灭菌。本发明的另一方面涉及将治疗活性剂持续递送至哺乳动物的方法 通过使用通过照射在降低的温度下灭菌的聚合物材料。

    Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and prostamide
    4.
    发明授权
    Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and prostamide 有权
    含有低血压脂质和前列腺酰胺的油包油乳化聚合物植入物

    公开(公告)号：US08445027B2

    公开(公告)日：2013-05-21

    申请号：US13152780

    申请日：2011-06-03

    申请人： Patrick M. Hughes ,  Michele Boix ,  Christian Sarrazin ,  Marina Do

    发明人： Patrick M. Hughes ,  Michele Boix ,  Christian Sarrazin ,  Marina Do

    IPC分类号： A61K9/50

    CPC分类号： A61K31/5575 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1075 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/165 ,  A61K31/216 ,  A61K47/34 ,  A61L2/081 ,  B01J13/02 ,  B01J13/04 ,  B01J13/06

    摘要： Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the polymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in an eye to treat or reduce at least one symptom of an ocular condition, such as glaucoma.

    摘要翻译： 生物相容性眼内植入物，例如微粒，包括有助于促进前列腺酰胺组分长时间释放到眼睛中的前列腺酰胺组分和可生物降解的聚合物。 前列腺酰胺组分可以与可生物降解的聚合物基质相结合，例如两种可生物降解聚合物的基质。 或者，前列腺酰胺组分可以被聚合物组分包封。 本植入物包括油包油乳化植入物或微粒。 还描述了生产本植入物的方法。 植入物可以放置在眼睛中以治疗或减少眼部疾病如青光眼的至少一种症状。

    Dendrimer-Drug Conjugates
    8.
    发明申请
    Dendrimer-Drug Conjugates 审中-公开
    树枝状大分子药物结合物

    公开(公告)号：US20080020043A1

    公开(公告)日：2008-01-24

    申请号：US11458901

    申请日：2006-07-20

    申请人： Marc Gingras ,  Jean-Manuel Raimundo ,  Yoann M. Chabre ,  Michele Boix ,  Marina Do ,  Christian Sarrazin ,  Laurent Delahaye

    发明人： Marc Gingras ,  Jean-Manuel Raimundo ,  Yoann M. Chabre ,  Michele Boix ,  Marina Do ,  Christian Sarrazin ,  Laurent Delahaye

    IPC分类号： A61K9/00

    CPC分类号： A61K47/60

    摘要： The present invention provides a drug-dendrimer conjugate comprising a central core, two or more linear hydrophilic molecules bonded thereto, a secondary core molecule bonded to at least a majority, if not all, of said first linear hydrophilic molecules, a drug or other biologically-active molecule bonded to the remainder of said first linear hydrophilic molecules or bonded to a segment comprising a second secondary core molecule which is bonded to said first secondary core molecule by a linear hydrophilic molecule, and wherein at least some of the bonds between said drug or other biologically active molecule and said first and/or second secondary core molecules are hydrolysable by an endogenous esterase.

    摘要翻译： 本发明提供了一种药物 - 树枝状大分子缀合物，其包含中心核心，两个或更多个与其键合的线性亲水性分子，二级核心分子结合至至少大部分（如果不是全部）所述第一线性亲水分子，药物或其他生物学 活性分子与所述第一线性亲水分子的剩余部分键合，或者键合到包含通过线性亲水分子键合到所述第一次级核心分子的第二次级核心分子的区段，并且其中所述药物之间的至少一些键 或其它生物活性分子，并且所述第一和/或第二次级核心分子可通过内源性酯酶水解。

    Tyrosine kinase microsphers
    10.
    发明申请
    Tyrosine kinase microsphers 有权
    酪氨酸激酶微球

    公开(公告)号：US20050244477A1

    公开(公告)日：2005-11-03

    申请号：US11119463

    申请日：2005-04-29

    申请人： Patrick Hughes ,  Christian Sarrazin ,  Elisabeth Rossi ,  Michele Boix

    发明人： Patrick Hughes ,  Christian Sarrazin ,  Elisabeth Rossi ,  Michele Boix

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/00 ,  A61K31/404 ,  A61F2/00

    CPC分类号： A61K9/0051 ,  A61K9/1647 ,  Y10T428/2985

    摘要： Biocompatible intraocular microspheres include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the microspheres can be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The microspheres can be placed into an eye to treat or reduce the occurrence of one or more ocular conditions.

    摘要翻译： 生物相容性眼内微球包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间后进入眼睛玻璃体。 微球的治疗剂可以与可生物降解的聚合物基质相结合，例如基本上不含聚乙烯醇的基质。 微球可以放置在眼睛中以治疗或减少一种或多种眼睛病症的发生。