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公开(公告)号：US20110143435A1
公开(公告)日：2011-06-16
申请号：US12992536
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译： 本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。
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公开(公告)号：US09339558B2
公开(公告)日：2016-05-17
申请号：US12992525
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/16 , A61K9/50 , C12N5/00 , C12N5/02 , C08F293/00 , C08F295/00 , C08F297/00 , A61K48/00 , A61K9/107 , C08F290/06 , C12N15/11 , C12N15/87
CPC分类号： A61K31/713 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F290/062 , C08F293/005 , C12N15/111 , C12N15/87 , C12N2320/32 , Y02A50/463
摘要： Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
摘要翻译： 本文提供了包含多种共聚物的胶束组合物。 在某些情况下，本文提供的胶束组件是pH敏感颗粒。
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公开(公告)号：US08822213B2
公开(公告)日：2014-09-02
申请号：US13127968
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
CPC分类号： A61K47/48715 , A61K47/48176 , A61K47/48246 , A61K47/48384 , A61K47/48507 , A61K47/48561 , A61K47/48569 , A61K47/48646 , A61K47/48676 , A61K47/58 , A61K47/64 , A61K47/6803 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K47/6879 , A61K47/6889 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/10
摘要： A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
摘要翻译： 用于将试剂递送至细胞的组合物，其包含双特异性亲和试剂和pH响应性膜去稳定化聚合物。 双特异性亲和试剂可以包括与第二亲和试剂共价连接的第一亲和试剂，其中第一亲和试剂与细胞表面上的分子结合，第二亲和试剂结合细胞内靶。
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公开(公告)号：US20110281354A1
公开(公告)日：2011-11-17
申请号：US13127968
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
IPC分类号： C12N5/071 , C08F126/06
CPC分类号： A61K47/48715 , A61K47/48176 , A61K47/48246 , A61K47/48384 , A61K47/48507 , A61K47/48561 , A61K47/48569 , A61K47/48646 , A61K47/48676 , A61K47/58 , A61K47/64 , A61K47/6803 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K47/6879 , A61K47/6889 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/10
摘要： A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
摘要翻译： 用于将试剂递送至细胞的组合物，其包含双特异性亲和试剂和pH响应性膜去稳定化聚合物。 双特异性亲和试剂可以包括与第二亲和试剂共价连接的第一亲和试剂，其中第一亲和试剂与细胞表面上的分子结合，第二亲和试剂结合细胞内靶。
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公开(公告)号：US09006193B2
公开(公告)日：2015-04-14
申请号：US12992536
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K47/48 , A01N43/04 , A61K48/00 , A61K47/30 , C12Q1/68 , C12N15/00 , C08F120/18 , C12N15/87 , A61K9/107 , C08F293/00
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译： 本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。
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公开(公告)号：US20110129921A1
公开(公告)日：2011-06-02
申请号：US12992545
申请日：2009-05-13
申请人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Chen-Chang Lee , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Chen-Chang Lee , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
CPC分类号： C07H21/02 , A61K47/58 , Y10T428/2982
摘要： Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.
摘要翻译： 聚合物生物共轭物具有共价偶联于pH依赖性的膜去稳定化聚合物的α或ω末端的RNAi试剂。
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7.发明申请OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION 有权欧米茄官能团聚合物，结构官能团嵌段共聚物，聚合物生物聚合物和放射链扩展聚合公开(公告)号：US20110305660A1
公开(公告)日：2011-12-15
申请号：US13133355
申请日：2009-12-08
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Scott M. Henry , Robert W. Overell , Paul H. Johnson
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Scott M. Henry , Robert W. Overell , Paul H. Johnson
IPC分类号： A61K31/795 , A61P9/00 , C08F120/56 , A61K31/787 , C08F120/34 , C08F293/00
CPC分类号： C08F293/005 , A61K47/58 , A61K49/0054 , C08F2/38 , C08F220/54 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.
摘要翻译： 描述了具有空间控制的生物共轭位点的聚合物。 官能化通过自由基聚合如可逆加成 - 断裂链转移（RAFT）聚合的聚合物链的选择性共末端链延伸来实现。
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公开(公告)号：US20110142951A1
公开(公告)日：2011-06-16
申请号：US12992541
申请日：2009-05-13
申请人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/14 , A61K31/7088 , C12N5/02
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/7105 , A61K47/551 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F293/005 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Composition comprising a polymeric micelle and an associated polynucleotide.
摘要翻译： 包含聚合胶束和相关多核苷酸的组合物。
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9.发明申请DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS 有权二嵌段共聚物和多核苷酸复合物，用于递送至细胞公开(公告)号：US20110143434A1
公开(公告)日：2011-06-16
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C12N5/071 , C08F293/00
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译： 本文描述的是共聚物，以及制备和利用这些共聚物的方法。 这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。 该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。 所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。 优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。 在具体实例中，共聚物是内体分解的。
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10.发明授权Diblock copolymers and polynucleotide complexes thereof for delivery into cells 有权二嵌段共聚物和其多核苷酸复合物用于递送到细胞中公开(公告)号：US09476063B2
公开(公告)日：2016-10-25
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C08F293/00 , C12N5/071 , C12N15/87 , C12N15/11
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译： 本文描述的是共聚物，以及制备和利用这些共聚物的方法。 这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。 该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。 所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。 优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。 在具体实例中，共聚物是内体分解的。
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