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公开(公告)号：US5654411A
公开(公告)日：1997-08-05
申请号：US435900
申请日：1995-05-04
申请人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
发明人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08 , C07H1/00
CPC分类号： C07H17/08
摘要： 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
摘要翻译： 4'' - 具有式（I）的红霉素的脱氧衍生物及其药学上可接受的盐，其是胃动力的增强剂，但是具有最小的抗菌活性，以及含有它们的药物组合物以及它们的方法 使用和准备。
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公开(公告)号：US5834438A
公开(公告)日：1998-11-10
申请号：US435903
申请日：1995-05-04
申请人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
发明人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08
CPC分类号： C07H17/08
摘要： 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
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公开(公告)号：US5578579A
公开(公告)日：1996-11-26
申请号：US284730
申请日：1994-08-02
申请人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
发明人： Paul A. Lartey , Larry L. Klein , Ramin Faghih , Hugh N. Nellans
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08
CPC分类号： C07H17/08
摘要： 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
摘要翻译： 4'' - 具有式（I）的红霉素的脱氧衍生物及其药学上可接受的盐，其是胃动力的增强剂，但是具有最小的抗菌活性，以及含有它们的药物组合物以及它们的方法 使用和准备。
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公开(公告)号：US5712253A
公开(公告)日：1998-01-27
申请号：US668050
申请日：1996-06-18
申请人： Paul A. Lartey , Cynthia Burnell Curty , Ramin Faghih , Hugh Nerby Nellans , Albert Christian Petersen
发明人： Paul A. Lartey , Cynthia Burnell Curty , Ramin Faghih , Hugh Nerby Nellans , Albert Christian Petersen
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/04 , A61P1/12 , A61P1/18 , A61P3/00 , A61P3/04 , A61P43/00 , C07H17/08
CPC分类号： C07H17/08
摘要： Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R.sup.1, R.sup.2, R.sup.3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.
摘要翻译： 衍生自具有式（I）的红霉素A和B的新型大环13-环收缩的化合物及其药学上可接受的盐，其中R，R 1，R 2，R 3和X具体定义，其用于 治疗与高肌钙蛋白血症相关的胃肠道疾病，其药物组合物，用所述药物组合物治疗与高肌醇酐血症相关的胃肠道疾病的方法及其制备方法。
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公开(公告)号：US5217960A
公开(公告)日：1993-06-08
申请号：US695176
申请日：1991-05-03
申请人： Paul A. Lartey , Ramin Faghih , Shari DeNinno
发明人： Paul A. Lartey , Ramin Faghih , Shari DeNinno
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
摘要： Antibacterial compounds are disclosed having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sup.1 is --NR.sup.4 R.sup.6, where R.sup.4 and R.sup.6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R.sup.4 and R.sup.6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R.sup.2 is selected from the group consisting of hydrogen, --OH and, when R.sup.3 is methylene, oxygen so as to form an epoxide; and R.sup.3 is selected from the group consisting of --CH.sub.2 OH, --NR.sup.4 R.sup.6, --(CH.sub.2).sub.n NR.sup.4 R.sup.6 and, when R.sup.2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R.sup.4 and R.sup.6 are as previously defined, with the proviso that when R.sup.2 is --OH, R.sup.3 may not be --NR.sup.4 R.sup.6 ; or R.sup.2 and R.sup.3 together are.dbd.CH.sub.2. Also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.
摘要翻译： 公开了具有下式的抗菌化合物及其药学上可接受的盐，其中R 1是-NR 4 R 6，其中R 4和R 6独立地选自氢，低级烷基和芳基烷基，或者R 4和R 6一起形成氮 - 在氮原子附着的杂环; R2选自氢，-OH，当R3为亚甲基时，为氧，形成环氧化物; 并且R 3选自-CH 2 OH，-NR 4 R 6， - （CH 2）n NR 4 R 6，并且当R 2为氧时，亚甲基以形成环氧化物，其中n为1-4，并且R 4和R 6如前所定义， 条件是当R 2是-OH时，R 3可以不是-NR 4 R 6; 或R 2和R 3一起为= CH 2。 还公开了可用于制备上述化合物的方法和中间体，以及含有其的组合物及其使用方法。
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公开(公告)号：US5773421A
公开(公告)日：1998-06-30
申请号：US548803
申请日：1995-12-21
申请人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
发明人： Lisa A. Alder , Marianna Jackson , Neal S. Burres , James B. McAlpine , Jill E. Hochlowski , Larry L. Klein , Paul A. Lartey , Clinton Yeung
IPC分类号： C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645 , A61K31/71 , C07H15/00 , C12P19/44
摘要： Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译： 具有下式的新型抗真菌剂：其中R是氢或-C（O）-R1，其中R 1是烯基，C 2 -C 12烷基，芳基，芳基烯基，芳基烷基，芳基 - 芳基 - ，芳基烷氧基 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 芳基 - 或芳基烷氧基 - 芳基 - 芳基 - 或其药学上可接受的盐，酯或前药，以及（i）包含这些化合物的药物组合物，（ii） 使用这种化合物的治疗，以及（iv）可用于制备该化合物的方法和真菌培养物。
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公开(公告)号：US5075289A
公开(公告)日：1991-12-24
申请号：US203400
申请日：1988-06-07
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P31/00 , A61P31/04 , C07H17/08 , C07H19/04
CPC分类号： C07H17/08
摘要： Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.
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8.发明授权D-manno-2-octulosonic acid derivatives, pharmaceutical compositions and method of use 失效D-壬烯-2-辛酮酸衍生物，药物组合物和使用方法
公开(公告)号：US4613589A
公开(公告)日：1986-09-23
申请号：US767212
申请日：1985-08-19
CPC分类号： C07H15/14 , C07D309/10 , C07H15/04 , C07H7/033
摘要： Derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.
摘要翻译： 3-脱氧-D-manno-2-octulosonic acid（KDO）的衍生物是细菌酶和新型抗菌剂的有效抑制剂。
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9.发明授权Amino D-manno-2-octulopyranosidonate containing compounds, pharmaceutical compositions and method of use 失效含氨基D-manno-2-octulopyranosidonate的化合物，药物组合物和使用方法
公开(公告)号：US4613590A
公开(公告)日：1986-09-23
申请号：US767297
申请日：1985-08-19
IPC分类号： C07D309/10 , C07H7/033 , C07H15/04 , A61K31/70 , C07H5/06
CPC分类号： C07H15/04 , C07D309/10 , C07H7/033
摘要： Aminodeoxy derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.
摘要翻译： 3-脱氧-D-manno-2-octulosonic acid（KDO）的氨基脱氧衍生物是细菌酶和新型抗菌剂的有效抑制剂。
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公开(公告)号：US4242503A
公开(公告)日：1980-12-30
申请号：US25237
申请日：1979-03-29
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： Described is a method of O-demethylating a fortimicin compound using hydriodic acid or tri-methylsilyiodide as an O-demethylating agent.
摘要翻译： 描述了使用氢碘酸或三甲基异硫脲作为O-去甲基化剂将抑霉素化合物O-去甲基化的方法。
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