公开(公告)号：US5789461A

公开(公告)日：1998-08-04

申请号：US683491

申请日：1996-07-18

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy S. Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy S. Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  F03H20060101 ,  G02B20060101 ,  G02B1/04 ,  G02C20060101 ,  H05H20060101

CPC分类号： A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

摘要： An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

摘要翻译： 适合在眼睛上延长穿戴至少一天的眼科镜片，而不会有临床显着量的角膜肿胀并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

公开(公告)号：US20090039535A1

公开(公告)日：2009-02-12

申请号：US12252406

申请日：2008-10-16

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, JR. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, JR. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： B29D11/00

CPC分类号： G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  A61L2430/16 ,  B05D1/62 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00076 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937 ,  C08L51/085 ,  C08L51/08 ,  C08L33/00 ,  C08L83/04 ,  C08L39/06 ,  C08G18/63 ,  C08G18/48

摘要： A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

摘要翻译： 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中，预聚物混合物在具有小于约ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜，其特征在于在连续磨损一段时间后产生小于10％的角膜溶胀 包括正常睡眠期的7天。 在一个实施方案中，预聚物混合物包含至少一种含有亲水基团的含氧物质，其中所述至少一种含氧物质是含硅氧烷的大分子单体或单体，至少一种离子精子材料和交联剂。 在某些实施方案中，预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。

公开(公告)号：US5965631A

公开(公告)日：1999-10-12

申请号：US108714

申请日：1998-07-01

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  G02B1/04 ,  G02C20060101

CPC分类号： G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  A61L2430/16 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

公开(公告)号：US5760100A

公开(公告)日：1998-06-02

申请号：US569816

申请日：1995-12-08

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  G02B1/04 ,  G02C20060101

CPC分类号： G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  A61L2430/16 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

摘要： An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

公开(公告)号：US08415404B2

公开(公告)日：2013-04-09

申请号：US12794333

申请日：2010-06-04

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02B1/04

CPC分类号： G02B1/043 ,  A61L27/26 ,  B29C39/42 ,  B29C71/00 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  C08L43/04 ,  C08L75/04 ,  C08L51/085 ,  C08L2666/20 ,  C08L51/08 ,  C08L83/04 ,  C08L33/00 ,  C08G18/63 ,  C08G18/48

摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。

公开(公告)号：US5849811A

公开(公告)日：1998-12-15

申请号：US682452

申请日：1996-07-17

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  G02B1/04 ,  G02C20060101 ,  C08F230/08

CPC分类号： G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  A61L2430/16 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

摘要： An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

摘要翻译： 适合在眼睛上延长穿戴至少一天的眼科镜片，而不会有临床显着量的角膜肿胀并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

公开(公告)号：US5776999A

公开(公告)日：1998-07-07

申请号：US682496

申请日：1996-07-17

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  F03H20060101 ,  G02B20060101 ,  G02B1/04 ,  G02C20060101 ,  H05H20060101

CPC分类号： A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

摘要： An ophthalmic lens screening method suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

摘要翻译： 一种眼镜片筛选方法，其适用于在眼睛上持续至少一天的延长磨损，而不会有临床显着量的角膜肿胀并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

公开(公告)号：US07468398B2

公开(公告)日：2008-12-23

申请号：US11146586

申请日：2005-06-07

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： C08F290/06

CPC分类号： G02B1/043 ,  A61L27/26 ,  B29C39/42 ,  B29C71/00 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  C08L43/04 ,  C08L75/04 ,  C08L51/085 ,  C08L2666/20 ,  C08L51/08 ,  C08L83/04 ,  C08L33/00 ,  C08G18/63 ,  C08G18/48

摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

公开(公告)号：US08568626B2

公开(公告)日：2013-10-29

申请号：US12252406

申请日：2008-10-16

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： B29D11/00

CPC分类号： G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  A61L2430/16 ,  B05D1/62 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00076 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937 ,  C08L51/085 ,  C08L51/08 ,  C08L33/00 ,  C08L83/04 ,  C08L39/06 ,  C08G18/63 ,  C08G18/48

摘要： A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

摘要翻译： 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中，预聚物混合物在具有小于约10000ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜，其特征在于连续磨损一段时间后产生小于10％的角膜溶胀 包括正常睡眠期为7天。 在一个实施方案中，预聚物混合物包含至少一种含有亲水基团的含氧物质，其中所述至少一种含氧物质是含硅氧烷的大分子单体或至少一种离子交换材料和交联剂。 在某些实施方案中，预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。

公开(公告)号：US07553880B2

公开(公告)日：2009-06-30

申请号：US11618798

申请日：2006-12-30

申请人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

发明人： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC分类号： G02B1/04

CPC分类号： G02B1/043 ,  A61L27/26 ,  B29C39/42 ,  B29C71/00 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  C08L43/04 ,  C08L75/04 ,  C08L51/085 ,  C08L2666/20 ,  C08L51/08 ,  C08L83/04 ,  C08L33/00 ,  C08G18/63 ,  C08G18/48

摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。