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11 条记录 (耗时 0.034 秒)

    Surgical device includes an anti-microbial coating
    3.
    发明授权
    Surgical device includes an anti-microbial coating 有权
    手术装置包括抗菌涂层

    公开(公告)号：US08080028B2

    公开(公告)日：2011-12-20

    申请号：US11294618

    申请日：2005-12-05

    申请人： Gerald D. Cagle

    发明人： Gerald D. Cagle

    IPC分类号： A61B17/32

    CPC分类号： A61B17/3211 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606

    摘要： A surgical knife blade or other surgical device containing an anti-microbial coating. The coating may be adhered to the device by a water-soluble adhesive that allows the anti-microbial coating to be released into the wound track. The coating may be of a consistency that allows a certain amount of the coating to slough off and pool or puddle around the surgical site as the surgical device is moved into and out of the surgical site.

    摘要翻译： 手术刀片或其他包含抗微生物涂层的手术装置。 涂层可以通过允许将抗微生物涂层释放到伤口轨道中的水溶性粘合剂粘附到装置上。 涂层可以是一致的，其允许一定量的涂层在外科手术装置移入和移出外科手术部位时脱落并且在手术部位周围聚集或聚集。

    Sustained release ophthalmic antibiotic compositions
    4.
    发明授权
    Sustained release ophthalmic antibiotic compositions 失效
    缓释眼用抗生素组合物

    公开(公告)号：US5985259A

    公开(公告)日：1999-11-16

    申请号：US846406

    申请日：1997-04-30

    申请人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    发明人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    IPC分类号： A61K9/00 ,  A61K31/496 ,  A61K31/70 ,  A61K31/74

    CPC分类号： A61K31/496 ,  A61K9/0048

    摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painfull and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.

    摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素的疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。

    System and Method for Detecting Amyloid Proteins
    8.
    发明申请
    System and Method for Detecting Amyloid Proteins 有权
    检测淀粉样蛋白的系统和方法

    公开(公告)号：US20130135580A1

    公开(公告)日：2013-05-30

    申请号：US13814677

    申请日：2011-08-12

    申请人： Paul D. Hartung ,  Vincent Valvo ,  Charles Kerbage ,  Gerald D. Cagle ,  Dennis J. Nilan

    发明人： Paul D. Hartung ,  Vincent Valvo ,  Charles Kerbage ,  Gerald D. Cagle ,  Dennis J. Nilan

    IPC分类号： A61B3/00 ,  A61B3/11 ,  A61B3/117

    CPC分类号： A61B5/14546 ,  A61B3/0008 ,  A61B3/1005 ,  A61B3/107 ,  A61B3/111 ,  A61B3/117 ,  A61B3/1173 ,  A61B3/135 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/1455 ,  A61B5/4088 ,  A61B5/6821 ,  A61B2562/0238 ,  A61B2562/0242

    摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.

    摘要翻译： 根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。 一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与 淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在 时间衰减率最小。

    Use of sustained release antibiotic compositions in ophthalmic surgical procedures
    9.
    发明授权
    Use of sustained release antibiotic compositions in ophthalmic surgical procedures 失效
    缓释抗生素组合物在眼科手术中的应用

    公开(公告)号：US06630135B1

    公开(公告)日：2003-10-07

    申请号：US09438987

    申请日：1999-11-12

    申请人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    发明人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    IPC分类号： A61K3170

    CPC分类号： A61K31/496 ,  A61K9/0048

    摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.

    摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。

    Use of sustained release antibiotic compositions in ophthalmic surgical procedures
    10.
    发明授权
    Use of sustained release antibiotic compositions in ophthalmic surgical procedures 失效
    缓释抗生素组合物在眼科手术中的应用

    公开(公告)号：US5631004A

    公开(公告)日：1997-05-20

    申请号：US129924

    申请日：1993-09-30

    申请人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    发明人： Gerald D. Cagle ,  Tai-Lee Ke ,  Barry A. Schlech ,  Ole J. Lorenzetti

    IPC分类号： A61K9/00 ,  A61K31/496 ,  A61K31/70 ,  A61K31/74

    CPC分类号： A61K31/496 ,  A61K9/0048

    摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.

    摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。