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公开(公告)号：US08012494B2
公开(公告)日：2011-09-06
申请号：US10794123
申请日：2004-03-05
申请人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
发明人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
IPC分类号： A61K9/00 , A61K31/70 , A61K31/335
CPC分类号： A61K9/1075 , A61K9/0007 , A61K9/485 , A61K9/4858 , A61K31/365
摘要： A pharmaceutical composition comprises at least one inhibitor of lipases, preferably an inhibitor of gastrointestinal and pancreatic lipases, such as orlistat, at least one surfactant, and at least one dispersant.
摘要翻译： 药物组合物包含至少一种脂肪酶抑制剂，优选胃肠和胰脂肪酶抑制剂，例如奥利司他，至少一种表面活性剂和至少一种分散剂。
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公开(公告)号：US6030953A
公开(公告)日：2000-02-29
申请号：US370845
申请日：1999-08-10
申请人： Jacques Bailly , Andre Fleury , Paul Hadvary , Hans Lengsfeld , Hans Steffen
发明人： Jacques Bailly , Andre Fleury , Paul Hadvary , Hans Lengsfeld , Hans Steffen
IPC分类号： C07D305/12 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/46 , A61K31/337 , A61K31/365 , A61K31/722 , A61K45/00 , A61K47/36 , A61P1/12 , A61P3/04 , A61P3/06 , A61P3/10 , A61P43/00 , A61K31/70 , A61K31/335 , A61K31/715
CPC分类号： A61K9/0095 , A61K31/365 , A61K47/36 , A61K9/0007 , A61K9/0056 , A61K9/1652 , Y10S514/922
摘要： The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of chitosan, its derivatives and salts thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.
摘要翻译： 本发明提供含有胃肠脂肪酶抑制剂的口服给药的药物组合物和至少一种选自壳聚糖，其衍生物和盐的化合物。 提供了用于预防和治疗口服给予含有胃肠脂肪酶抑制剂的组合物的患者的油的肛门泄漏的方法。
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公开(公告)号：US06703369B1
公开(公告)日：2004-03-09
申请号：US09660700
申请日：2000-09-13
申请人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Marcel Schmid , Donald MacFarland Small , Hans Steffen , Joseph Tardio
发明人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Marcel Schmid , Donald MacFarland Small , Hans Steffen , Joseph Tardio
IPC分类号： A61K3170
CPC分类号： A61K9/4858 , A61K9/0007 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K31/365
摘要： A pharmaceutical composition contains at least one inhibitor of lipases and at least one fatty acid ester of polyol. In this composition, the fatty acid ester has a melting point above the body temperature and the polyols are chosen from the group consisting of sugars, sugar derivatives, and mixtures thereof.
摘要翻译： 药物组合物含有至少一种脂肪酶抑制剂和多元醇的至少一种脂肪酸酯。 在该组合物中，脂肪酸酯具有高于体温的熔点，多元醇选自糖，糖衍生物及其混合物。
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公开(公告)号：US20060189574A1
公开(公告)日：2006-08-24
申请号：US11408232
申请日：2006-04-20
申请人： Paul Hadvary , Hans Lengsfeld , Hans Steffen
发明人： Paul Hadvary , Hans Lengsfeld , Hans Steffen
IPC分类号： A61K31/724 , A61K31/365
CPC分类号： A61K31/365 , A61K31/00 , A61K31/785 , Y10S514/824
摘要： A method prevents or treats diseases associated with high plasma cholesterol levels. In addition, this method reduces plasma cholesterol levels. The method comprises administering a lipase inhibitor, e.g. orlistat, and a pharmaceutically acceptable bile acid sequestrant.
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公开(公告)号：US20110275706A1
公开(公告)日：2011-11-10
申请号：US13185558
申请日：2011-07-19
申请人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
发明人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
IPC分类号： A61K31/337 , A61P3/04
CPC分类号： A61K9/1075 , A61K9/0007 , A61K9/485 , A61K9/4858 , A61K31/365
摘要： A pharmaceutical composition comprises at least one inhibitor of lipases, preferably an inhibitor of gastrointestinal and pancreatic lipases, such as orlistat, at least one surfactant, and at least one dispersant.
摘要翻译： 药物组合物包含至少一种脂肪酶抑制剂，优选胃肠和胰脂肪酶抑制剂，例如奥利司他，至少一种表面活性剂和至少一种分散剂。
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公开(公告)号：US06562329B2
公开(公告)日：2003-05-13
申请号：US09912956
申请日：2001-07-25
申请人： Paul Hadvary , Hans Lengsfeld , Hans Steffen
发明人： Paul Hadvary , Hans Lengsfeld , Hans Steffen
IPC分类号： A61K3174
CPC分类号： A61K31/365 , A61K31/00 , A61K31/785 , Y10S514/824
摘要： A method prevents or treats diseases associated with high plasma cholesterol levels. In addition, this method reduces plasma cholesterol levels. The method comprises administering a lipase inhibitor, e.g. orlistat, and a pharmaceutically acceptable bile acid sequestrant.
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公开(公告)号：US5848990A
公开(公告)日：1998-12-15
申请号：US911198
申请日：1997-08-14
IPC分类号： A61M5/142 , A61M20060101 , A61M5/14 , A61M5/158 , A61M5/20 , A61M5/31 , A61M5/32 , A61M25/06 , A61M37/00
CPC分类号： A61M25/0612 , A61M5/158 , A61M5/3287 , A61M2005/14252 , A61M2005/1426 , A61M2005/1581 , A61M2005/1585
摘要： A device for introducing an active substance solution into a patient and with means for fastening to the skin and a cannula. The cannula is held in a withdrawn position by a retaining and releasing mechanism before use and, after release, is propelled into the patient's skin. A connector connected to the rear of the cannula serves to connect the cannula to an active substance reservoir.
摘要翻译： 一种用于将活性物质溶液引入患者体内并具有用于紧固至皮肤和套管的装置。 在使用之前，套管通过保持和释放机构保持在撤回位置，并且在释放之后被推进到患者的皮肤中。 连接到套管后部的连接器用于将套管连接到活性物质储存器。
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公开(公告)号：US5747066A
公开(公告)日：1998-05-05
申请号：US612047
申请日：1996-03-07
申请人： Folker Pittrof , Hans Steffen
发明人： Folker Pittrof , Hans Steffen
CPC分类号： A61K8/0291 , A61K8/671 , A61K8/676 , A61K8/678 , A61K9/1075 , A61Q19/00 , C07F9/10 , Y10S514/937 , Y10T428/2984
摘要： Mixed micelles for the aqueous solubilization of active substances which are difficultly soluble or insoluble in water with improved storage properties consist of a phosphatide having saturated, branched fatty acid residues and a bile acid salt or dihexanoyllecithin.
摘要翻译： 难溶于或不溶于水的活性物质的水溶性增溶混合胶束具有改善的储存性能，由具有饱和，支链脂肪酸残基和胆汁酸盐或二己酰胆碱酯的磷脂组成。
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公开(公告)号：US4411894A
公开(公告)日：1983-10-25
申请号：US293587
申请日：1981-08-17
申请人： Jurg Schrank , Hans Steffen
发明人： Jurg Schrank , Hans Steffen
CPC分类号： A61K31/55 , A61K31/47 , A61K9/1277 , Y10S514/97
摘要： Pharmaceutical compositions useful for the parenteral administration of fat-soluble medicaments are disclosed. The compositions comprise, in addition to the medicaments, a sugar-containing liposome solution or lyophilizates thereof.
摘要翻译： 公开了可用于口服给药脂溶性药物的药物组合物。 除了药物之外，组合物还包含含糖脂质体溶液或其冻干物质。
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公开(公告)号：US4886499A
公开(公告)日：1989-12-12
申请号：US129018
申请日：1987-12-04
申请人： Giorgio Cirelli , Hans Steffen , Christian Surber
发明人： Giorgio Cirelli , Hans Steffen , Christian Surber
CPC分类号： A61M5/14593 , A61M5/142 , A61M5/14248 , A61M2005/14204 , A61M2005/14252 , A61M2005/14264 , A61M2005/14268 , A61M5/16881 , Y10S128/12
摘要： The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emptying the vessel through the injection needle; securing means for securing the appliance to an appropriate part of the patient's body; and needle-driving means for shooting the injection needle into the patient's skin.
摘要翻译： 便携式器具可用于皮下或皮下注射活性成分的液体制剂，并且其组合包括用于制剂的供应容器; 适于与所述容器连通的注射针; 用于通过注射针排空容器的泵装置; 用于将所述器具固定到患者身体的适当部分的固定装置; 以及用于将注射针射入患者皮肤的针驱动装置。
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