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1.发明申请公开(公告)号：US20060020295A1
公开(公告)日：2006-01-26
申请号：US10897856
申请日：2004-07-23
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
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2.发明申请Systems and methods for drug therapy enhancement using expected pharmacodynamic models 有权使用预期药效学模型增强药物治疗的系统和方法公开(公告)号：US20060089592A1
公开(公告)日：2006-04-27
申请号：US10970449
申请日：2004-10-21
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2205/3561 , A61M2230/04 , A61M2230/08 , A61M2230/30 , A61M2230/50 , A61M2230/63 , G06F19/00 , G06F19/3456 , G16H50/50 , Y10S128/923
摘要： A system or method including a device configured to measure at least one pharmacological effect of a drug on a patient. The measured pharmacological effect is compared to an expected pharmacodynamic model. The system can allow for real-time monitoring of positive and side-effects of drugs as well as drug resistance to optimize individual therapy. The system can also enable patient compliance monitoring.
摘要翻译： 一种包括被配置为测量药物对患者的至少一种药理作用的装置的系统或方法。 将测量的药理作用与预期的药效学模型进行比较。 该系统可以实时监测药物的阳性和副作用以及耐药性，以优化个体治疗。 该系统还可以实现患者依从性监控。
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公开(公告)号：US20060010090A1
公开(公告)日：2006-01-12
申请号：US10889353
申请日：2004-07-12
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译： 使用多个慢性传感器来促进个体患者的诊断和医学决策。 专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。
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公开(公告)号：US20060276849A1
公开(公告)日：2006-12-07
申请号：US11142851
申请日：2005-06-01
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
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5.发明申请Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds 有权使用心脏声音优化心脏再同步治疗的方法和装置公开(公告)号：US20060020294A1
公开(公告)日：2006-01-26
申请号：US10865498
申请日：2004-06-10
CPC分类号： A61B5/0538 , A61B5/0809 , A61B5/113 , A61B5/7203 , A61B5/726 , A61B7/00 , A61N1/36514 , G06K9/00496
摘要： A cardiac rhythm management system provides for assessment of cardiac mechanical dyssynchrony based on heart sound morphology and optimization of pacing parameters based on the effect of pacing on the cardiac mechanical dyssynchrony assessment. A degree of cardiac mechanical dyssynchrony is measured by the time delay between tricuspid valve closure and mitral valve closure and/or the time delay between pulmonary valve closure and aortic valve closure. A cardiac resynchronization therapy is optimized by determining therapy parameters to provide an approximately minimum degree of cardiac mechanical dyssynchrony by cardiac pacing.
摘要翻译： 心脏节律管理系统基于心脏机械不同步评估的起搏效果，提供基于心脏声音形态和起搏参数优化的心脏机械不同步的评估。 通过三尖瓣关闭和二尖瓣关闭之间的时间延迟和/或肺动脉瓣关闭与主动脉瓣闭合之间的时间延迟来测量心脏机械不同步程度。 通过确定治疗参数来优化心脏再同步治疗，以通过心脏起搏提供心脏机械不同步的近似程度。
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6.发明申请公开(公告)号：US20070162080A1
公开(公告)日：2007-07-12
申请号：US11687812
申请日：2007-03-19
IPC分类号： A61N1/365
CPC分类号： A61B5/0538 , A61B5/0809 , A61B5/113 , A61B5/7203 , A61B5/726 , A61B7/00 , A61N1/36514 , G06K9/00496
摘要： A cardiac rhythm management system provides for assessment of cardiac mechanical dyssynchrony based on heart sound morphology and optimization of pacing parameters based on the effect of pacing on the cardiac mechanical dyssynchrony assessment. A degree of cardiac mechanical dyssynchrony is measured by the time delay between tricuspid valve closure and mitral valve closure and/or the time delay between pulmonary valve closure and aortic valve closure. A cardiac resynchronization therapy is optimized by determining therapy parameters to provide an approximately minimum degree of cardiac mechanical dyssynchrony by cardiac pacing.
摘要翻译： 心脏节律管理系统基于心脏机械不同步评估的起搏效果，提供基于心脏声音形态和起搏参数优化的心脏机械不同步的评估。 通过三尖瓣关闭和二尖瓣关闭之间的时间延迟和/或肺动脉瓣关闭与主动脉瓣闭合之间的时间延迟来测量心脏机械不同步程度。 通过确定治疗参数来优化心脏再同步治疗，以通过心脏起搏提供心脏机械不同步的近似程度。
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公开(公告)号：US20070078491A1
公开(公告)日：2007-04-05
申请号：US11465878
申请日：2006-08-21
申请人： Krzysztof Siejko , Laura Green , Gerrard Carlson
发明人： Krzysztof Siejko , Laura Green , Gerrard Carlson
IPC分类号： A61N1/00
CPC分类号： A61B7/006 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/4836 , A61B5/6847 , A61B5/7275 , A61B7/04 , A61B2562/0204 , A61B2562/0219 , A61N1/36514 , A61N1/37 , A61N1/3987
摘要： A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart beats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.
摘要翻译： 心律管理系统提供第三心音（S3）指数的趋势。 S3指数是S3跳动次数与所有心跳次数的比率或比率的估计，其中S3跳动各自是检测到S3的发生的心跳。 诸如加速度计或麦克风的可植入传感器感测到包括S3的指示心音的声信号。 S3检测器从声信号检测出S3的发生。 心脏声音处理系统周期性地推动S3指数，以允许连续监测S3活动水平，这表明与心力衰竭有关的病症。
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公开(公告)号：US20060161210A1
公开(公告)日：2006-07-20
申请号：US11037723
申请日：2005-01-18
申请人： Joseph Pastore , Rodney Salo , Gerrard Carlson , Andrew Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph Pastore , Rodney Salo , Gerrard Carlson , Andrew Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362
CPC分类号： A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/36592 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.
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9.发明申请System and method for assessing cardiac performance through cardiac vibration monitoring 有权通过心脏振动监测评估心脏性能的系统和方法公开(公告)号：US20060155204A1
公开(公告)日：2006-07-13
申请号：US11367852
申请日：2006-03-03
申请人： Ramesh Wariar , Gerrard Carlson
发明人： Ramesh Wariar , Gerrard Carlson
IPC分类号： A61B5/02
摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译： 描述了通过心脏振动监测来评估心脏性能的系统和方法。 通过植入式医疗设备直接收集心脏振动。 识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。 第一个心音与胸腔内压力作用的心脏尺寸相关。 心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。 针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。
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公开(公告)号：US20060270939A1
公开(公告)日：2006-11-30
申请号：US11135985
申请日：2005-05-24
IPC分类号： A61B5/02
摘要： A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.
摘要翻译： 监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。 该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与 病人的心。 该装置还包括耦合到心脏声音传感器的控制器电路。 控制器电路测量分别对应于每个轴的心音的分量。
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