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1.发明申请NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF 有权用于甲状腺激素类似物的纳米颗粒和聚合物配方，其拮抗剂及其制剂及其用途公开(公告)号：US20110052715A1
公开(公告)日：2011-03-03
申请号：US12816287
申请日：2010-06-15
CPC分类号： A61K9/5031 , A61K31/192 , A61K41/0038 , A61K45/06 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/6455 , A61K47/6937 , B82Y5/00 , Y10T428/2982
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素激动剂，部分激动剂或其拮抗剂的聚合物纳米颗粒形式，以促进或抑制受试者的血管发生。 还公开了甲状腺激素或甲状腺激素类似物的纳米颗粒形式及其用途。
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2.发明授权Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof 有权用于甲状腺激素类似物，拮抗剂及其制剂和用途的纳米颗粒和聚合物制剂公开(公告)号：US09220788B2
公开(公告)日：2015-12-29
申请号：US12816287
申请日：2010-06-15
CPC分类号： A61K9/5031 , A61K31/192 , A61K41/0038 , A61K45/06 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/6455 , A61K47/6937 , B82Y5/00 , Y10T428/2982
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素激动剂，部分激动剂或其拮抗剂的聚合物纳米颗粒形式，以促进或抑制受试者的血管发生。 还公开了甲状腺激素或甲状腺激素类似物的纳米颗粒形式及其用途。
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3.发明申请Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof 审中-公开用于甲状腺激素类似物，拮抗剂及其制剂的纳米颗粒和聚合物制剂及其用途公开(公告)号：US20090022806A1
公开(公告)日：2009-01-22
申请号：US12004979
申请日：2007-12-21
申请人： Shaker A. Mousa , Paul J. Davis , Aleck Hercbergs
发明人： Shaker A. Mousa , Paul J. Davis , Aleck Hercbergs
IPC分类号： A61K9/14 , A61K31/704 , A61K31/7048 , A61K31/66 , A61K31/505 , A61K33/24 , A61K31/337 , A61K31/7072 , A61K31/282 , A61K31/4353 , A61K31/69 , A61P35/00
CPC分类号： A61K9/5153 , A61B5/055 , A61B5/4082 , A61B5/4088 , A61B6/037 , A61K9/0019 , A61K9/0048 , A61K9/1075 , A61K31/282 , A61K31/337 , A61K31/4353 , A61K31/505 , A61K31/66 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K45/06
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的聚合物纳米颗粒形式的甲状腺激素激动剂，其部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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公开(公告)号：US09655984B2
公开(公告)日：2017-05-23
申请号：US13643907
申请日：2011-04-28
IPC分类号： A61K51/00 , A61K31/195 , A61K45/06 , A61K31/4164 , A61K31/513 , A61K31/198
CPC分类号： A61K51/00 , A61K31/195 , A61K31/198 , A61K31/4164 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention encompasses a therapeutic method which employs treatment of a disease such as cancer with triiodothyronine (T3) together with an anti-thyroid treatment such as treatment with an anti-thyroid agent, treatment with radioiodine and surgical removal of all or part of the thyroid gland. A pharmaceutical composition comprising T3 and an anti-thyroid agent and a kit comprising the same are also encompassed by the invention.
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公开(公告)号：US20130129615A1
公开(公告)日：2013-05-23
申请号：US13643907
申请日：2011-04-28
IPC分类号： A61K51/00 , A61K31/513 , A61K31/4164 , A61K31/195
CPC分类号： A61K51/00 , A61K31/195 , A61K31/198 , A61K31/4164 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention encompasses a therapeutic method which employs treatment of a disease such as cancer with triiodothyronine (T3) together with an anti-thyroid treatment such as treatment with an anti-thyroid agent, treatment with radioiodine and surgical removal of all or part of the thyroid gland. A pharmaceutical composition comprising T3 and an anti-thyroid agent and a kit comprising the same are also encompassed by the invention.
摘要翻译： 本发明包括使用三碘甲状腺原氨酸（T3）治疗诸如癌症的疾病与抗甲状腺治疗如抗甲状腺药物的治疗方法，用放射性碘治疗和手术切除全部或部分 甲状腺。 包含T3和抗甲状腺剂的药物组合物和包含该组合物的试剂盒也包括在本发明中。
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公开(公告)号：US10398789B2
公开(公告)日：2019-09-03
申请号：US15484691
申请日：2017-04-11
IPC分类号： A61K51/00 , A61K31/195 , A61K45/06 , A61K31/4164 , A61K31/513 , A61K31/198
摘要： The present invention encompasses a therapeutic method which employs treatment of a disease such as cancer with triiodothyronine (T3) together with an anti-thyroid treatment such as treatment with an anti-thyroid agent, treatment with radioiodine and surgical removal of all or part of the thyroid gland. A pharmaceutical composition comprising T3 and an anti-thyroid agent and a kit comprising the same are also encompassed by the invention.
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