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1.发明申请NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF 有权用于甲状腺激素类似物的纳米颗粒和聚合物配方，其拮抗剂及其制剂及其用途公开(公告)号：US20110052715A1
公开(公告)日：2011-03-03
申请号：US12816287
申请日：2010-06-15
CPC分类号： A61K9/5031 , A61K31/192 , A61K41/0038 , A61K45/06 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/6455 , A61K47/6937 , B82Y5/00 , Y10T428/2982
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素激动剂，部分激动剂或其拮抗剂的聚合物纳米颗粒形式，以促进或抑制受试者的血管发生。 还公开了甲状腺激素或甲状腺激素类似物的纳米颗粒形式及其用途。
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2.发明申请Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof 审中-公开用于甲状腺激素类似物，拮抗剂及其制剂的纳米颗粒和聚合物制剂及其用途公开(公告)号：US20090022806A1
公开(公告)日：2009-01-22
申请号：US12004979
申请日：2007-12-21
申请人： Shaker A. Mousa , Paul J. Davis , Aleck Hercbergs
发明人： Shaker A. Mousa , Paul J. Davis , Aleck Hercbergs
IPC分类号： A61K9/14 , A61K31/704 , A61K31/7048 , A61K31/66 , A61K31/505 , A61K33/24 , A61K31/337 , A61K31/7072 , A61K31/282 , A61K31/4353 , A61K31/69 , A61P35/00
CPC分类号： A61K9/5153 , A61B5/055 , A61B5/4082 , A61B5/4088 , A61B6/037 , A61K9/0019 , A61K9/0048 , A61K9/1075 , A61K31/282 , A61K31/337 , A61K31/4353 , A61K31/505 , A61K31/66 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K45/06
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的聚合物纳米颗粒形式的甲状腺激素激动剂，其部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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3.发明授权Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof 有权用于甲状腺激素类似物，拮抗剂及其制剂和用途的纳米颗粒和聚合物制剂公开(公告)号：US09220788B2
公开(公告)日：2015-12-29
申请号：US12816287
申请日：2010-06-15
CPC分类号： A61K9/5031 , A61K31/192 , A61K41/0038 , A61K45/06 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/645 , A61K47/6455 , A61K47/6937 , B82Y5/00 , Y10T428/2982
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素激动剂，部分激动剂或其拮抗剂的聚合物纳米颗粒形式，以促进或抑制受试者的血管发生。 还公开了甲状腺激素或甲状腺激素类似物的纳米颗粒形式及其用途。
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公开(公告)号：US20120258069A1
公开(公告)日：2012-10-11
申请号：US13156047
申请日：2011-06-08
CPC分类号： G01N33/5023 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , C12N15/1086
摘要： Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
摘要翻译： 本文提供了通过靶向选择的细胞外和细胞外蛋白质的RGD结合位点来预防和治疗与代谢综合征相关的疾病和危险因素的组合物和方法。 典型的组合物包括通过酯键的RGD-多酚共轭物; 与RGD类似物或模拟物缀合的多酚聚合物; 和与多酚连接的RGD聚合物缀合物。
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公开(公告)号：US08071134B2
公开(公告)日：2011-12-06
申请号：US11663047
申请日：2005-09-15
申请人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
发明人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
CPC分类号： A61K31/192 , A61K31/195 , A61K31/4365 , A61K31/60 , A61K31/7076 , A61K31/727 , A61K38/1825 , A61K38/1866 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K49/0008 , A61K49/085 , A61K49/10 , A61K49/12 , A61K51/0402 , A61K51/0497 , A61K51/065 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/43 , A61L2300/606 , A61K2300/00
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素或其拮抗剂的聚合形式，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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6.发明授权Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof 有权用于甲状腺激素类似物，拮抗剂及其制剂和用途的纳米颗粒和聚合物制剂公开(公告)号：US09289395B2
公开(公告)日：2016-03-22
申请号：US12947389
申请日：2010-11-16
申请人： Paul J. Davis , Shaker A. Mousa
发明人： Paul J. Davis , Shaker A. Mousa
IPC分类号： A61K9/14 , A61K9/51 , A61K31/192 , A61K47/48 , B82Y5/00
CPC分类号： A61K9/5153 , A61K31/192 , A61K47/593 , A61K47/595 , A61K47/60 , A61K47/61 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的聚合物纳米颗粒形式的甲状腺激素激动剂，其部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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7.发明授权Methods of stimulating fat mobilization using a polymer conjugated polyphenol 有权使用聚合物缀合的多酚刺激脂肪动员的方法公开(公告)号：US09272049B2
公开(公告)日：2016-03-01
申请号：US13156047
申请日：2011-06-08
CPC分类号： G01N33/5023 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , C12N15/1086
摘要： Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
摘要翻译： 本文提供了通过靶向选择的细胞外和细胞外蛋白质的RGD结合位点来预防和治疗与代谢综合征相关的疾病和危险因素的组合物和方法。 典型的组合物包括通过酯键的RGD-多酚共轭物; 与RGD类似物或模拟物缀合的多酚聚合物; 和与多酚连接的RGD聚合物缀合物。
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8.发明授权Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells 有权甲状腺激素类似物及其纳米颗粒形式的制剂的使用以增加肿瘤或癌细胞中的化学敏感性和放射敏感性公开(公告)号：US08802240B2
公开(公告)日：2014-08-12
申请号：US13345194
申请日：2012-01-06
申请人： Paul J. Davis , Shaker A. Mousa
发明人： Paul J. Davis , Shaker A. Mousa
IPC分类号： A61K31/198 , A61K31/192 , A61K31/704 , A61P29/00
CPC分类号： C07K16/2848 , A61K31/192 , A61K31/198 , A61K31/282 , A61K31/337 , A61K31/4375 , A61K31/4545 , A61K31/513 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39533 , A61K45/06 , A61K2039/505 , B82Y5/00 , Y10T428/12729 , Y10T428/31815 , A61K2300/00
摘要： Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof.
摘要翻译： 公开了使用甲状腺激素类似物和/或其纳米颗粒或聚合物形式增加正常和/或化学抗性肿瘤或癌细胞的化学敏感性的方法。 还公开了使用甲状腺激素类似物和/或其纳米颗粒或聚合形式增加正常和/或放射抗性肿瘤或癌细胞的放射敏感性的方法。
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公开(公告)号：US09198887B2
公开(公告)日：2015-12-01
申请号：US14078713
申请日：2013-11-13
申请人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
发明人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
IPC分类号： A61K31/192 , A61K45/06 , A61K31/7068 , A61K31/225 , A61K31/337 , A61K31/704
CPC分类号： A61K31/192 , A61K31/225 , A61K31/337 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的甲状腺激素或其拮抗剂的聚合形式，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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10.发明授权Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof 有权用于甲状腺激素类似物，拮抗剂及其制剂的纳米颗粒和聚合物制剂公开(公告)号：US08668926B1
公开(公告)日：2014-03-11
申请号：US11786723
申请日：2007-04-11
申请人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
发明人： Shaker A. Mousa , Faith B. Davis , Paul J. Davis
IPC分类号： A61K9/127
CPC分类号： A61K31/198 , A61K9/0048 , A61K9/5153 , A61K31/192 , A61K31/195 , A61K31/4365 , A61K31/60 , A61K31/65 , A61K31/7076 , A61K31/727 , A61K39/44 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/68 , A61K47/6801 , A61K47/6811 , A61K47/6937 , A61K47/6939 , A61K49/0008 , A61K49/085 , A61K49/10 , A61K49/12 , A61K51/0402 , A61K51/0497 , A61K51/065 , C07K16/2848 , C07K2317/76 , Y10T428/2982
摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的聚合物纳米颗粒形式的甲状腺激素激动剂，其部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。 还公开了甲状腺激素或甲状腺激素类似物的聚合形式的组合物。
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