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公开(公告)号：US5306352A
公开(公告)日：1994-04-26
申请号：US7809
申请日：1993-01-22
CPC分类号： A61L2/18 , A01N59/00 , A61L12/126 , A61L12/128
摘要： A method of disinfecting a hydrogen peroxide stable material by contacting said material with a hydrogen peroxide containing solution and a hydrogen peroxide decomposition means adapted to permit said material to have a cumulative (% peroxide).multidot.(min) exposure from the time said decomposition means contacts said hydrogen peroxide containing solution over a period not exceeding 12 hours of at least 20% (peroxide).multidot.(min). Also, disclosed are devices and components thereof whereby said method can be achieved.
摘要翻译： 通过使所述材料与含过氧化氢的溶液和过氧化氢分解装置接触来消毒过氧化氢稳定材料的方法，其适于允许所述材料从所述分解装置接触时起累积的（％过氧化物）*（最小）曝光 所述含过氧化氢的溶液在不超过12小时的时间内至少为20％（过氧化物）*（分钟）。 此外，公开了其可以实现所述方法的装置和组件。
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公开(公告)号：US5468448A
公开(公告)日：1995-11-21
申请号：US112637
申请日：1993-08-26
CPC分类号： A61L2/18 , A01N59/00 , A61L12/126 , A61L12/128 , Y10S514/839 , Y10S514/84
摘要： A method of disinfecting a hydrogen peroxide stable contact lens is provided wherein a contact lens is contacted with a hydrogen peroxide solution in a container and a hydrogen peroxide decomposition means is provided in said container, which means is adapted to permit the contact lens to have a cumulative (% peroxide) (min) exposure from the time said decomposition means contacts said peroxide containing solution, time zero, over a period of no greater than 12 hours of at least 20% peroxide.multidot.minute. An apparatus capable of carrying out such method is also provided herein. The hydrogen peroxide decomposition means may be, for example, a prepoisoned catalyst, a catalyst partially enclosed in a tube, a dual catalyst control system or a distributed catalyst control system.
摘要翻译： 提供消毒过氧化氢稳定性隐形眼镜的方法，其中隐形眼镜与容器中的过氧化氢溶液接触，并且在所述容器中设置过氧化氢分解装置，这意味着允许隐形眼镜具有 从所述分解装置接触所述含过氧化物的溶液的时间（时间零），在不超过12小时的时间内至少20％过氧化物分钟的累积（过氧化氢）（最小）暴露。 本文还提供了能够执行这种方法的装置。 过氧化氢分解装置可以是例如预先使用的催化剂，部分封装在管中的催化剂，双催化剂控制系统或分散催化剂控制系统。
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公开(公告)号：US5078798A
公开(公告)日：1992-01-07
申请号：US458123
申请日：1989-12-28
申请人： Paul Nicolson , Kenneth R. Seamons , Fu-Pao Tsao
发明人： Paul Nicolson , Kenneth R. Seamons , Fu-Pao Tsao
CPC分类号： A01N59/00 , A61L12/126 , A61L12/128 , A61L2/18
摘要： A method of carrying out a reaction in a solution catalytically comprising contacting a solid catalytically active material and a solution in which a catalytic reaction is to be carried out wherein the catalytic reaction yields a gas which adheres to the catalyst particles such that as the reaction is substantially complete in the immediate environment of the catalyst, the catalyst migrates to a reactant richer portion.
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公开(公告)号：US20080096978A1
公开(公告)日：2008-04-24
申请号：US11961034
申请日：2007-12-20
申请人： Fu-Pao Tsao
发明人： Fu-Pao Tsao
IPC分类号： A61K47/26
CPC分类号： A61K9/0048 , A61K31/716 , A61K33/40 , A61K47/08 , A61K47/24 , A61K47/36 , A61K2300/00
摘要： An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such solutions, are provided.
摘要翻译： 包含过氧化氢源的眼用溶液，其量足以导致作为防腐剂的所述制剂中稳定的过氧化氢的约0.001％至约0.01％，一种或多种与眼睛相容的过氧化氢稳定剂，羟丙基甲基纤维素和羧甲基纤维素钠， 以及包含这种溶液的药物组合物。
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公开(公告)号：US5858996A
公开(公告)日：1999-01-12
申请号：US863855
申请日：1997-05-27
申请人： Fu-Pao Tsao
发明人： Fu-Pao Tsao
IPC分类号： A61K9/08 , A61K9/00 , A61K47/24 , C08K5/5317 , A01N57/00
CPC分类号： A61K9/0048 , C08K5/5317 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915
摘要： Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.
摘要翻译： 用于降低聚合物生物粘合剂和粘度增强剂（例如聚（丙烯酸））的分解速率的组合物和方法。 组合物包括至少一种强稳定的螯合剂，优选有机亚磷化合物，例如二亚乙基三胺五（亚甲基膦酸）。 这些生物相容性组合物特别适用于眼科领域。
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公开(公告)号：US5683993A
公开(公告)日：1997-11-04
申请号：US493761
申请日：1995-06-22
申请人： Fu-Pao Tsao
发明人： Fu-Pao Tsao
IPC分类号： A61K9/08 , A61K9/00 , A61K47/24 , C08K5/5317 , A61K31/66
CPC分类号： A61K9/0048 , C08K5/5317 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915
摘要： Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.
摘要翻译： 用于降低聚合物生物粘合剂和粘度增强剂（例如聚（丙烯酸））的分解速率的组合物和方法。 组合物包括至少一种强稳定的螯合剂，优选有机亚磷化合物，例如二亚乙基三胺五（亚甲基膦酸）。 这些生物相容性组合物特别适用于眼科领域。
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7.发明授权Rapid method for cleaning/disinfecting ophthalmic devices using novel glycol/lower alkanol solution 失效使用新型二醇/低级烷醇溶液清洗/消毒眼科装置的快速方法
公开(公告)号：US5411598A
公开(公告)日：1995-05-02
申请号：US198930
申请日：1994-02-18
申请人： Fu-Pao Tsao , Susan A. Littlefield , John H. Stone
发明人： Fu-Pao Tsao , Susan A. Littlefield , John H. Stone
CPC分类号： C11D3/2003 , A61L12/147 , C11D3/0078 , C11D3/2044 , C11D3/48 , Y10S514/839 , Y10S514/84
摘要： A rapid cleaning and disinfecting method and composition for ophthalmic devices, e.g. contact lenses. The composition includes, on a weight basis, 10-50% of a C.sub.3-8 alkylene glycol, 2-30% of a lower alkanol, 2-15% of a surfactant, 0-2% pH adjusting agent, 0-5% tonicity builder, viscosity enhancing agent in an amount from 0 to the amount required to bring the solution viscosity to 100 cps, and the balance water. The method involves mechanically rubbing the ophthalmic device with the cleaning/disinfecting composition followed by rinsing the device.
摘要翻译： 用于眼科装置的快速清洁和消毒方法和组合物，例如 隐形眼镜。 该组合物包含10-50％的C3-8亚烷基二醇，2-30％的低级链烷醇，2-15％的表面活性剂，0-2％的pH调节剂，0-5％ 增稠剂，粘度增加剂的量为0至使溶液粘度达到100cps所需的量，余量为水。 该方法包括用清洁/消毒组合物机械地摩擦眼科装置，然后冲洗该装置。
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8.发明授权Rapid ophthalmic disinfection method and solution using salt and glycol and/or lower alkanol 失效快速眼科消毒方法和使用盐和二醇和/或低级链烷醇的溶液
公开(公告)号：US5411597A
公开(公告)日：1995-05-02
申请号：US116820
申请日：1993-09-03
申请人： Fu-Pao Tsao , Susan A. Littlefield , John H. Stone
发明人： Fu-Pao Tsao , Susan A. Littlefield , John H. Stone
IPC分类号： A61L2/18 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/39 , A61K8/40 , A61K8/49 , A61L12/14 , A61Q5/00 , A61Q5/02 , C11D3/00 , C11D3/20 , C11D3/48 , C11D10/02 , C11D3/40 , C11D17/08
CPC分类号： C11D3/48 , A61L12/147 , C11D3/0078 , C11D3/2044 , C11D3/201 , Y10S514/839 , Y10S514/84
摘要： A disinfection solution, primarily for use in conjunction with contact lenses is disclosed comprising an amount of a pharmaceutically acceptable ionic salt which is equivalent in ionic strength to at least 5% w/v sodium chloride, at least one of a C.sub.2-6 alkanol and a C.sub.3-8 alkylene glycol, a pharmaceutically acceptable surfactant, optionally a buffer, and water.
摘要翻译： 公开了主要与隐形眼镜一起使用的消毒溶液，其包含一定量的药学上可接受的离子盐，其离子强度相当于至少5％w / v氯化钠，至少一种C 2-6链烷醇和 C3-8亚烷基二醇，药学上可接受的表面活性剂，任选的缓冲剂和水。
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公开(公告)号：US20080207692A1
公开(公告)日：2008-08-28
申请号：US12082845
申请日：2008-04-15
申请人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
发明人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
CPC分类号： A61K31/4535 , A61K9/0048
摘要： Ophthalmic compositions comprising ketotifen and a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v) of hydrogen peroxide, and methods for the treatment and prevention of allergic conjunctivitis using these compositions are provided herein.
摘要翻译： 提供包含酮替芬和提供约0.001至约0.1％（w / v）过氧化氢的过氧化氢量的过氧化氢源的眼用组合物，以及使用这些组合物治疗和预防变应性结膜炎的方法。
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公开(公告)号：US20070161523A1
公开(公告)日：2007-07-12
申请号：US11599977
申请日：2006-11-15
申请人： Fu-Pao Tsao
发明人： Fu-Pao Tsao
IPC分类号： C11D3/00
CPC分类号： A61L12/142 , C11D1/008 , C11D1/66 , C11D3/0078 , C11D3/2065 , C11D3/225 , C11D3/3726 , C11D3/3776 , C11D3/48
摘要： The present invention provides a lens care composition having a persistent cleaning-efficacy characterized by substantially maintaining the light transmittance at around 280 nm of a contact lens after at least 15 cycles of soiling with a soiling solution containing proteins and subsequent cleaning with the lens care composition of the invention. The lens care composition comprises at least one surfactant, a polyvinylpyrrolidone (PVP), a cellulose ether, and xylitol, wherein in combination with polyvinylpyrrolidone (PVP), a cellulose ether, and xylitol, the surfactant provides the persistent cleaning-efficacy.
摘要翻译： 本发明提供了一种具有持久清洁效果的透镜护理组合物，其特征在于在用含有蛋白质的污渍溶液污染至少15个循环之后，基本保持隐形眼镜约280nm处的透光率，随后用镜片护理组合物进行清洁 的本发明。 透镜护理组合物包含至少一种表面活性剂，聚乙烯吡咯烷酮（PVP），纤维素醚和木糖醇，其中与聚乙烯吡咯烷酮（PVP），纤维素醚和木糖醇组合，表面活性剂提供持久的清洁效能。
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